×

ZIC3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol ZIC3
Entrez Gene ID 7547
Full Name Zic family member 3
Synonyms HTX, HTX1, VACTERLX, ZNF203
General protein information
Preferred Names
zinc finger protein ZIC 3
Names
zinc finger protein ZIC 3
heterotaxy 1
zinc finger protein 203
zinc finger protein of the cerebellum 3
Zic family member 3 (odd-paired homolog, Drosophila)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq26.2

Summary This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

300265

Disorder Html: Heterotaxy, visceral, 1, X-linked 306955 (3); Congenital heart

mRNA and Protein(s)

mRNA Protein Name
NM_003413 NP_003404 zinc finger protein ZIC 3



Homo sapiens (human) ZIC3 NP_003404.1
Canis lupus familiaris (dog) ZIC3 XP_549291.3
Bos taurus (cattle) ZIC3 NP_001179742.1
Mus musculus (house mouse) Zic3 NP_033601.2
Gallus gallus (chicken) ZIC3 XP_420237.4
Danio rerio (zebrafish) zic3 NP_001001950.1
Xenopus (Silurana) tropicalis (western clawed frog) zic3 NP_001005691.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ZIC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZIC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Free ORF Clone
for Every Scientist
More Detail >>

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18212
NM_003413 Homo sapiens Zic family member 3 (ZIC3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18212
Clone ID Related Accession (Same CDS sequence) NM_003413
Accession Version NM_003413.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1404bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product zinc finger protein ZIC 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035443.4. This sequence is a reference standard in the RefSeqGene project. On Jul 16, 2008 this sequence version replaced gi:22547199. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF028706.1, EU532020.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGACGATGC TCCTGGACGG AGGCCCGCAG TTCCCTGGGC TGGGAGTGGG CAGCTTCGGC 
GCGCCGCGCC ACCACGAGAT GCCCAACCGT GAGCCGGCAG GCATGGGGCT GAATCCCTTC
GGGGACTCAA CCCACGCCGC CGCCGCCGCC GCCGCCGCCG CTGCCTTCAA GCTGAGCCCT
GCCGCGGCGC ACGATCTATC TTCAGGCCAG AGCTCGGCTT TCACGCCGCA GGGTTCGGGC
TACGCCAACG CCCTGGGCCA CCATCACCAC CACCATCACC ATCATCACCA CACCAGCCAG
GTGCCCAGCT ACGGTGGCGC TGCCTCTGCC GCCTTCAACT CAACGCGCGA GTTTCTGTTC
CGCCAGCGCA GCTCCGGGCT CAGTGAGGCG GCCTCGGGTG GCGGGCAGCA CGGGCTCTTC
GCCGGCTCGG CGAGCAGCCT GCATGCTCCA GCTGGCATCC CCGAGCCCCC TAGCTACTTG
CTGTTTCCCG GGCTGCATGA GCAGGGCGCT GGGCACCCGT CGCCCACAGG GCACGTGGAC
AACAACCAGG TCCACCTGGG GCTGCGTGGG GAGCTGTTCG GCCGTGCTGA CCCATACCGC
CCAGTGGCCA GCCCGCGCAC GGACCCCTAC GCGGCCGGCG CTCAGTTTCC TAACTACAGC
CCCATGAACA TGAACATGGG AGTGAACGTG GCGGCCCACC ACGGGCCCGG CGCCTTCTTC
CGTTATATGC GGCAGCCTAT CAAGCAGGAG CTGTCGTGCA AGTGGATCGA CGAGGCTCAG
CTGAGCCGGC CCAAGAAGAG CTGCGACCGG ACCTTCAGCA CCATGCATGA GCTGGTGACA
CATGTCACCA TGGAGCATGT GGGGGGCCCG GAGCAGAACA ACCACGTCTG CTACTGGGAG
GAGTGCCCCC GGGAGGGCAA GTCTTTCAAG GCGAAGTACA AACTGGTCAA CCACATCCGA
GTGCACACGG GCGAGAAGCC CTTCCCATGC CCCTTCCCGG GCTGCGGGAA GATCTTTGCC
CGTTCTGAGA ACCTCAAGAT CCACAAGAGG ACCCACACAG GTGAGAAACC TTTCAAATGT
GAATTTGAAG GCTGTGACAG ACGCTTTGCC AACAGCAGCG ACCGTAAGAA GCACATGCAT
GTGCATACCT CGGACAAGCC CTATATCTGC AAAGTGTGCG ACAAGTCCTA CACGCACCCG
AGCTCCCTGC GCAAACACAT GAAGGTTCAT GAATCTCAAG GGTCAGATTC CTCCCCTGCT
GCCAGTTCAG GCTATGAATC TTCCACTCCA CCCGCTATAG CTTCTGCAAA CAGTAAAGAT
ACCACTAAAA CCCCTTCTGC AGTTCAAACT AGCACCAGCC ACAACCCTGG ACTTCCTCCT
AATTTTAACG AATGGTACGT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003404.1
CDS506..1909
Misc Feature(1)236..238(+)
Misc Feature(2)1394..1471(+)
Misc Feature(3)1409..1471(+)
Misc Feature(4)1409..1471(+)
Misc Feature(5)1424..1648(+)
Misc Feature(6)1448..1528(+)
Misc Feature(7)1493..1561(+)
Misc Feature(8)1493..1561(+)
Misc Feature(9)1493..1558(+)
Misc Feature(10)1535..1618(+)
Misc Feature(11)1583..1651(+)
Misc Feature(12)1583..1651(+)
Misc Feature(13)1592..1651(+)
Misc Feature(14)1598..1651(+)
Misc Feature(15)1604..1732(+)
Misc Feature(16)1625..1702(+)
Misc Feature(17)1667..1735(+)
Misc Feature(18)1673..1735(+)
Misc Feature(19)1673..1735(+)
Exon (1)1..1565
Gene:ZIC3
Gene Synonym:
Exon (2)1566..1729
Gene:ZIC3
Gene Synonym:
Exon (3)1730..3939
Gene:ZIC3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003413
Organism Homo sapiens (human)
Definition Homo sapiens Zic family member 3 (ZIC3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003413

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGACGATGC TCCTGGACGG AGGCCCGCAG TTCCCTGGGC TGGGAGTGGG CAGCTTCGGC 
GCGCCGCGCC ACCACGAGAT GCCCAACCGT GAGCCGGCAG GCATGGGGCT GAATCCCTTC
GGGGACTCAA CCCACGCCGC CGCCGCCGCC GCCGCCGCCG CTGCCTTCAA GCTGAGCCCT
GCCGCGGCGC ACGATCTATC TTCAGGCCAG AGCTCGGCTT TCACGCCGCA GGGTTCGGGC
TACGCCAACG CCCTGGGCCA CCATCACCAC CACCATCACC ATCATCACCA CACCAGCCAG
GTGCCCAGCT ACGGTGGCGC TGCCTCTGCC GCCTTCAACT CAACGCGCGA GTTTCTGTTC
CGCCAGCGCA GCTCCGGGCT CAGTGAGGCG GCCTCGGGTG GCGGGCAGCA CGGGCTCTTC
GCCGGCTCGG CGAGCAGCCT GCATGCTCCA GCTGGCATCC CCGAGCCCCC TAGCTACTTG
CTGTTTCCCG GGCTGCATGA GCAGGGCGCT GGGCACCCGT CGCCCACAGG GCACGTGGAC
AACAACCAGG TCCACCTGGG GCTGCGTGGG GAGCTGTTCG GCCGTGCTGA CCCATACCGC
CCAGTGGCCA GCCCGCGCAC GGACCCCTAC GCGGCCGGCG CTCAGTTTCC TAACTACAGC
CCCATGAACA TGAACATGGG AGTGAACGTG GCGGCCCACC ACGGGCCCGG CGCCTTCTTC
CGTTATATGC GGCAGCCTAT CAAGCAGGAG CTGTCGTGCA AGTGGATCGA CGAGGCTCAG
CTGAGCCGGC CCAAGAAGAG CTGCGACCGG ACCTTCAGCA CCATGCATGA GCTGGTGACA
CATGTCACCA TGGAGCATGT GGGGGGCCCG GAGCAGAACA ACCACGTCTG CTACTGGGAG
GAGTGCCCCC GGGAGGGCAA GTCTTTCAAG GCGAAGTACA AACTGGTCAA CCACATCCGA
GTGCACACGG GCGAGAAGCC CTTCCCATGC CCCTTCCCGG GCTGCGGGAA GATCTTTGCC
CGTTCTGAGA ACCTCAAGAT CCACAAGAGG ACCCACACAG GTGAGAAACC TTTCAAATGT
GAATTTGAAG GCTGTGACAG ACGCTTTGCC AACAGCAGCG ACCGTAAGAA GCACATGCAT
GTGCATACCT CGGACAAGCC CTATATCTGC AAAGTGTGCG ACAAGTCCTA CACGCACCCG
AGCTCCCTGC GCAAACACAT GAAGGTTCAT GAATCTCAAG GGTCAGATTC CTCCCCTGCT
GCCAGTTCAG GCTATGAATC TTCCACTCCA CCCGCTATAG CTTCTGCAAA CAGTAAAGAT
ACCACTAAAA CCCCTTCTGC AGTTCAAACT AGCACCAGCC ACAACCCTGG ACTTCCTCCT
AATTTTAACG AATGGTACGT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Sumoylation regulates nuclear localization and function of zinc finger transcription factor ZIC3
Biochim. Biophys. Acta 1833 (12), 2725-2733 (2013)
Chen L, Ma Y, Qian L and Wang J.


book

The phenotypic spectrum of ZIC3 mutations includes isolated d-transposition of the great arteries and double outlet right ventricle
Am. J. Med. Genet. A 161A (4), 792-802 (2013)
D'Alessandro LC, Latney BC, Paluru PC and Goldmuntz E.


book

Situs inversus totalis and a novel ZIC3 mutation in a family with X-linked heterotaxy
Congenit Heart Dis 8 (2), E36-E40 (2013)
D'Alessandro LC, Casey B and Siu VM.


book

Mutations in ZIC3 and ACVR2B are a common cause of heterotaxy and associated cardiovascular anomalies
Cardiol Young 22 (2), 194-201 (2012)
Ma L, Selamet Tierney ES, Lee T, Lanzano P and Chung WK.


book

Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease
PLoS ONE 6 (8), E23755 (2011)
Bedard JE, Haaning AM and Ware SM.


book

Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in Hispanic populations
Am. J. Med. Genet. A 116A (4), 414-415 (2003)
Zhu,H., Junker,W.M., Finnell,R.H., Brown,S., Shaw,G.M., Lammer,E.J., Canfield,M. and Hendricks,K.


book

Physical and functional interactions between Zic and Gli proteins
J. Biol. Chem. 276 (10), 6889-6892 (2001)
Koyabu Y, Nakata K, Mizugishi K, Aruga J and Mikoshiba K.


book

A deletion encompassing Zic3 in bent tail, a mouse model for X-linked neural tube defects
Hum. Mol. Genet. 9 (11), 1615-1622 (2000)
Klootwijk R, Franke B, van der Zee CE, de Boer RT, Wilms W, Hol FA and Mariman EC.


book

X-linked situs abnormalities result from mutations in ZIC3
Nat. Genet. 17 (3), 305-308 (1997)
Gebbia M, Ferrero GB, Pilia G, Bassi MT, Aylsworth A, Penman-Splitt M, Bird LM, Bamforth JS, Burn J, Schlessinger D, Nelson DL and Casey B.


book

Mapping a gene for familial situs abnormalities to human chromosome Xq24-q27.1
Nat. Genet. 5 (4), 403-407 (1993)
Casey B, Devoto M, Jones KL and Ballabio A.


 
*
*
*
*