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DERL1 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol DERL1
Entrez Gene ID 79139
Full Name derlin 1
Synonyms DER-1,DER1,derlin-1
General protein information
Preferred Names

derlin 1

Names

derlin-1
DERtrin-1
Der1-like domain family, member 1
degradation in endoplasmic reticulum protein 1
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

8

8q24.13
Summary The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012].
Disorder MIM:

608813


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_006716657.1 XP_006716720.1 derlin-1 isoform X1
NM_001363963.1 NP_001350892.1 derlin-1 isoform c
NM_001330601.1 NP_001317530.1 derlin-1 isoform c
NM_001134671.2 NP_001128143.1 derlin-1 isoform b
NM_024295.5 NP_077271.1 derlin-1 isoform a
NM_024295.6 NP_077271.1 derlin-1 isoform a

Pathways from BioSystems


Homologies


DERL1 XP_001099154.1
Mus musculus (house mouse) Derl1 NP_077169.1
Rattus norvegicus (Norway rat) Derl1 NP_001014224.1
Gallus gallus (chicken) DERL1 NP_001006350.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP009288 XP_320085.4
Caenorhabditis elegans (roundworm) cup-2 NP_492721.1
Xenopus tropicalis (tropical clawed frog) derl1 NP_001016723.1
Drosophila melanogaster (fruit fly) Der-1 NP_608632.1
Homo sapiens (human) DERL1 NP_077271.1
Pan troglodytes (chimpanzee) DERL1 XP_519933.1
Danio rerio (zebrafish) derl1 NP_998609.1
Canis lupus familiaris (dog) DERL1 XP_532320.2
Bos taurus (cattle) DERL1 NP_991358.1

Gene Ontology


Bibliography

Related articles in PubMed

Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling.
Dong Q, Fu L, Zhao Y, Tan S, Wang E
Oncotarget8(10)17059-17069(2017 Mar)

TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1?/Derlin-1 pathway.
Zheng J, Liu X, Xue Y, Gong W, Ma J, Xi Z, Que Z, Liu Y
Journal of hematology & oncology10(1)52(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.
Title: Derlin-1 promotes ubiquitylation and degradation of the epithelial Na

Derlin-1 is overexpressed in bladder cancer and promotes malignant phenotype through ERK/MMP-2/9 and PI3K/AKT signaling pathway.
Title: Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling.

ChIP assays were used to ascertain the correlations between HNF1beta and Derlin-1 in the miR-217/HNF1beta/Derlin-1 pathway in glioma cells
Title: TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1?/Derlin-1 pathway.

insights into the interactions between other SHP-containing proteins and p97N
Title: Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease.

Derlin-1 was overexpressed in bladder cancer and was associated with the malignancy of bladder cancer.
Title: High Expression of Derlin-1 Is Associated with the Malignancy of Bladder Cancer in a Chinese Han Population.

The following DERL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DERL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu14130 NM_024295.6
Latest version!		 Homo sapiens derlin 1 (DERL1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$49.50-$69.30
$99.00
OHu42582 NM_001363963.1
Latest version!		 Homo sapiens derlin 1 (DERL1), transcript variant 4, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $69.30
$99.00
OHu42582 NM_001330601.1
Latest version!		 Homo sapiens derlin 1 (DERL1), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $69.30
$99.00
OHu42582 XM_006716657.1
Latest version!		 Homo sapiens derlin 1 (DERL1), transcript variant X2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $69.30
$99.00
OHu07182 NM_001134671.2
Latest version!		 Homo sapiens derlin 1 (DERL1), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00
View Old Accession Versions >>
OHu14130 NM_024295.5 Homo sapiens derlin 1 (DERL1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$49.50-$69.30
$99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu14130
Clone ID Related Accession (Same CDS sequence) NM_024295.5 , NM_024295.6
Accession Version NM_024295.5 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 756bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-17
Organism Homo sapiens(human)
Product derlin-1 isoform a
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA800358.1, AY358818.1, AK023846.1, AF131854.1 and AA976062.1. On Aug 24, 2012 this sequence version replaced NM_024295.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.95145.1, SRR1660809.180544.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCGGACA TCGGAGACTG GTTCAGGAGC ATCCCGGCGA TCACGCGCTA TTGGTTCGCC 
GCCACCGTCG CCGTGCCCTT GGTCGGCAAA CTCGGCCTCA TCAGCCCGGC CTACCTCTTC 
CTCTGGCCCG AAGCCTTCCT TTATCGCTTT CAGATTTGGA GGCCAATCAC TGCCACCTTT 
TATTTCCCTG TGGGTCCAGG AACTGGATTT CTTTATTTGG TCAATTTATA TTTCTTATAT 
CAGTATTCTA CGCGACTTGA AACAGGAGCT TTTGATGGGA GGCCAGCAGA CTATTTATTC 
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_077271.1
CDS302..1057
Translation

Target ORF information:

RefSeq Version NM_024295.5
Organism Homo sapiens(human)
Definition Homo sapiens derlin 1 (DERL1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_024295.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCGGACA TCGGAGACTG GTTCAGGAGC ATCCCGGCGA TCACGCGCTA TTGGTTCGCC 
GCCACCGTCG CCGTGCCCTT GGTCGGCAAA CTCGGCCTCA TCAGCCCGGC CTACCTCTTC 
CTCTGGCCCG AAGCCTTCCT TTATCGCTTT CAGATTTGGA GGCCAATCAC TGCCACCTTT 
TATTTCCCTG TGGGTCCAGG AACTGGATTT CTTTATTTGG TCAATTTATA TTTCTTATAT 
CAGTATTCTA CGCGACTTGA AACAGGAGCT TTTGATGGGA GGCCAGCAGA CTATTTATTC 
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu14130
Clone ID Related Accession (Same CDS sequence) NM_024295.5 , NM_024295.6
Accession Version NM_024295.6 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 756bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-13
Organism Homo sapiens(human)
Product derlin-1 isoform a
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA800358.1, AY358818.1, AK023846.1, AF131854.1 and AA976062.1. On Nov 23, 2018 this sequence version replaced NM_024295.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.95145.1, SRR1660809.180544.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259512.9/ ENSP00000259512.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCGGACA TCGGAGACTG GTTCAGGAGC ATCCCGGCGA TCACGCGCTA TTGGTTCGCC 
GCCACCGTCG CCGTGCCCTT GGTCGGCAAA CTCGGCCTCA TCAGCCCGGC CTACCTCTTC 
CTCTGGCCCG AAGCCTTCCT TTATCGCTTT CAGATTTGGA GGCCAATCAC TGCCACCTTT 
TATTTCCCTG TGGGTCCAGG AACTGGATTT CTTTATTTGG TCAATTTATA TTTCTTATAT 
CAGTATTCTA CGCGACTTGA AACAGGAGCT TTTGATGGGA GGCCAGCAGA CTATTTATTC 
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_077271.1
CDS181..936
Translation

Target ORF information:

RefSeq Version NM_024295.6
Organism Homo sapiens(human)
Definition Homo sapiens derlin 1 (DERL1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_024295.6

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCGGACA TCGGAGACTG GTTCAGGAGC ATCCCGGCGA TCACGCGCTA TTGGTTCGCC 
GCCACCGTCG CCGTGCCCTT GGTCGGCAAA CTCGGCCTCA TCAGCCCGGC CTACCTCTTC 
CTCTGGCCCG AAGCCTTCCT TTATCGCTTT CAGATTTGGA GGCCAATCAC TGCCACCTTT 
TATTTCCCTG TGGGTCCAGG AACTGGATTT CTTTATTTGG TCAATTTATA TTTCTTATAT 
CAGTATTCTA CGCGACTTGA AACAGGAGCT TTTGATGGGA GGCCAGCAGA CTATTTATTC 
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu42582
Clone ID Related Accession (Same CDS sequence) XM_006716657.1 , NM_001363963.1 , NM_001330601.1
Accession Version NM_001363963.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 456bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-13
Organism Homo sapiens(human)
Product derlin-1 isoform c
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA823869.1, AY358818.1, AK023846.1, AF131854.1 and AA976062.1. On Jun 3, 2018 this sequence version replaced XM_006716657.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA823869.1, SRR5189655.94642.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001350892.1
CDS86..541
Translation

Target ORF information:

RefSeq Version NM_001363963.1
Organism Homo sapiens(human)
Definition Homo sapiens derlin 1 (DERL1), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001363963.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu42582
Clone ID Related Accession (Same CDS sequence) XM_006716657.1 , NM_001363963.1 , NM_001330601.1
Accession Version NM_001330601.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 456bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-13
Organism Homo sapiens(human)
Product derlin-1 isoform c
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104316.3. On Aug 29, 2016 this sequence version replaced XM_011517299.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.200917.1, SRR1803616.119882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151358, SAMEA2158569 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001317530.1
CDS490..945
Translation

Target ORF information:

RefSeq Version NM_001330601.1
Organism Homo sapiens(human)
Definition Homo sapiens derlin 1 (DERL1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001330601.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu42582
Clone ID Related Accession (Same CDS sequence) XM_006716657.1 , NM_001363963.1 , NM_001330601.1
Accession Version XM_006716657.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 456bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product derlin-1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006716720.1
CDS86..541
Translation

Target ORF information:

RefSeq Version XM_006716657.1
Organism Homo sapiens(human)
Definition Homo sapiens derlin 1 (DERL1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006716657.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCGGTA ATCAATGAGC TTATTGGAAA TCTGGTTGGA 
CATCTTTATT TTTTCCTAAT GTTCAGATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu07182
Clone ID Related Accession (Same CDS sequence) NM_001134671.2
Accession Version NM_001134671.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 696bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-13
Organism Homo sapiens(human)
Product derlin-1 isoform b
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA800358.1, DA906855.1, AK124086.1, AY358818.1, AK023846.1, AF131854.1 and AA976062.1. On Aug 24, 2012 this sequence version replaced NM_001134671.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.53784.1, SRR1660803.193719.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA TCGGAGACTG GTTCAGGAGC ATCCCGGCGA TCACGCGCTA TTGGTTCGCC 
GCCACCGTCG CCGTGCCCTT GGTCGGCAAA CTCGGCCTCA TCAGCCCGGC CTACCTCTTC 
CTCTGGCCCG AAGCCTTCCT TTATCGCTTT CAGATTTGGA GGCCAATCAC TGCCACCTTT 
TATTTCCCTG TGGGTCCAGG AACTGGATTT CTTTATTTGG TCAATTTATA TTTCTTATAT 
CAGTATTCTA CGCGACTTGA AACAGGAGCT TTTGATGGGA GGCCAGCAGA CTATTTATTC 
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001128143.1
CDS302..997
Translation

Target ORF information:

RefSeq Version NM_001134671.2
Organism Homo sapiens(human)
Definition Homo sapiens derlin 1 (DERL1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001134671.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA TCGGAGACTG GTTCAGGAGC ATCCCGGCGA TCACGCGCTA TTGGTTCGCC 
GCCACCGTCG CCGTGCCCTT GGTCGGCAAA CTCGGCCTCA TCAGCCCGGC CTACCTCTTC 
CTCTGGCCCG AAGCCTTCCT TTATCGCTTT CAGATTTGGA GGCCAATCAC TGCCACCTTT 
TATTTCCCTG TGGGTCCAGG AACTGGATTT CTTTATTTGG TCAATTTATA TTTCTTATAT 
CAGTATTCTA CGCGACTTGA AACAGGAGCT TTTGATGGGA GGCCAGCAGA CTATTTATTC 
ATGCTCCTCT TTAACTGGAT TTGCATCGTG ATTACTGGCT TAGCAATGGA TATGCAGTTG 
CTGATGATTC CTCTGATCAT GTCAGTACTT TATGTCTGGG CCCAGCTGAA CAGAGACATG 
ATTGTATCAT TTTGGTTTGG AACACGATTT AAGGCCTGCT ATTTACCCTG GGTTATCCTT 
GGATTCAACT ATATCATCGG AGGCTCATAC CCAATGGACT TGGGAGGAAG AAATTTTCTA 
TCCACACCTC AGTTTTTGTA CCGCTGGCTG CCCAGTAGGA GAGGAGGAGT ATCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTTCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Derlin-1 overexpression confers poor prognosis in muscle invasive bladder cancer and contributes to chemoresistance and invasion through PI3K/AKT and ERK/MMP signaling.
Oncotarget8(10)17059-17069(2017 Mar)
Dong Q,Fu L,Zhao Y,Tan S,Wang E


book

TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1?/Derlin-1 pathway.
Journal of hematology & oncology10(1)52(2017 Feb)
Zheng J,Liu X,Xue Y,Gong W,Ma J,Xi Z,Que Z,Liu Y