Gene Symbol | CDCA3 |
Entrez Gene ID | 83461 |
Full Name | cell division cycle associated 3 |
Synonyms | GRCC8,TOME-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » CDCA3 cDNA ORF clone
gRNAs
Gene Symbol | CDCA3 |
Entrez Gene ID | 83461 |
Full Name | cell division cycle associated 3 |
Synonyms | GRCC8,TOME-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_031299.6 | NP_112589.1 | cell division cycle-associated protein 3 isoform 1 |
NM_001331019.1 | NP_001317948.1 | cell division cycle-associated protein 3 isoform 5 |
NM_001297603.2 | NP_001284532.1 | cell division cycle-associated protein 3 isoform 3 |
NM_001297604.2 | NP_001284533.1 | cell division cycle-associated protein 3 isoform 4 |
NM_031299.5 | NP_112589.1 | cell division cycle-associated protein 3 isoform 1 |
XM_011521027.1 | XP_011519329.1 | cell division cycle-associated protein 3 isoform X1 |
NM_001297602.2 | NP_001284531.1 | cell division cycle-associated protein 3 isoform 2 |
Homo sapiens (human) | CDCA3 | NP_112589.1 |
Bos taurus (cattle) | CDCA3 | NP_001030526.1 |
Gallus gallus (chicken) | CDCA3 | NP_001265065.1 |
Canis lupus familiaris (dog) | CDCA3 | XP_854397.1 |
CDCA3 | XP_001118284.2 | |
Rattus norvegicus (Norway rat) | Cdca3 | NP_001007649.1 |
Xenopus tropicalis (tropical clawed frog) | cdca3 | XP_004915835.1 |
Pan troglodytes (chimpanzee) | CDCA3 | XP_508969.2 |
Mus musculus (house mouse) | Cdca3 | NP_038566.1 |
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
OY-TES-1 downregulation in liver cancer cells promotes cell proliferation by upregulating CCND2 and CDCA3.
Title: OY-TES-1 may regulate the malignant behavior of liver cancer via NANOG, CD9, CCND2 and CDCA3: a bioinformatic analysis combine with RNAi and oligonucleotide microarray.
High CDCA3 expression is associated with neoplasms.
Title: Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.
HoxB3 promote prostate cancer progression by upregulating CDCA3 expression.
Title: HoxB3 promotes prostate cancer cell progression by transactivating CDCA3.
overexpression of CDCA3 occurs frequently during oral carcinogenesis.
Title: Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
The following CDCA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDCA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu28862![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_031299.6 , NM_031299.5 , XM_011521027.1 | |
Accession Version | NM_031299.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | cell division cycle-associated protein 3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U47924.1 and AK291421.1. On Sep 3, 2016 this sequence version replaced NM_031299.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291421.1, SRR1163657.577827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_112589.1 |
CDS | 767..1573 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28862![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_031299.6 , NM_031299.5 , XM_011521027.1 | |
Accession Version | NM_031299.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-14 | |
Organism | Homo sapiens(Human) | |
Product | cell division cycle-associated protein 3 isoform 1 | |
Comment |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_112589.1 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28862![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_031299.6 , NM_031299.5 , XM_011521027.1 | |
Accession Version | XM_011521027.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | cell division cycle-associated protein 3 isoform X1 | |
Comment |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011519329.1 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28863 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297602.2 | |
Accession Version | NM_001297602.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | cell division cycle-associated protein 3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U47924.1. On Sep 3, 2016 this sequence version replaced NM_001297602.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.525725.1, BM559656.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284531.1 |
CDS | 767..1498 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28864 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297603.2 | |
Accession Version | NM_001297603.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | cell division cycle-associated protein 3 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U47924.1, AK291421.1 and AK092246.1. On Sep 3, 2016 this sequence version replaced NM_001297603.1. Transcript Variant: This variant (3) differs in the 3' structure, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a distinct C-terminus, and is shorter, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK092246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151358 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284532.1 |
CDS | 767..1426 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28865 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297604.2 | |
Accession Version | NM_001297604.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | cell division cycle-associated protein 3 isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U47924.1, BQ961607.1 and AK291421.1. On Sep 3, 2016 this sequence version replaced NM_001297604.1. Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (4) has a distinct C-terminus, and is shorter, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.194728.1, SRR1163657.48664.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284533.1 |
CDS | 767..1315 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTCAG CCAAGAGCGT CCCAGTCACA CCAGCGCGGC CTCCGCCGCA CAACAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu100704 | |
Clone ID Related Accession (Same CDS sequence) | NM_001331019.1 | |
Accession Version | NM_001331019.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | cell division cycle-associated protein 3 isoform 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U47924.1, AV714087.1 and AK291421.1. Transcript Variant: This variant (6) differs in the both the 5' and 3' coding regions and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus and distict, shorter C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV714087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGACCA GCAGTGGAGA CCCCCCAAGC CCACTGGTGA AACAGCTGAG TGAAGTATTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317948.1 |
CDS | 821..1138 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGACCA GCAGTGGAGA CCCCCCAAGC CCACTGGTGA AACAGCTGAG TGAAGTATTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Architecture of the human interactome defines protein communities and disease networks. |