Gene Symbol | YPEL3 |
Entrez Gene ID | 83719 |
Full Name | yippee like 3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » YPEL3 cDNA ORF clone
Gene Symbol | YPEL3 |
Entrez Gene ID | 83719 |
Full Name | yippee like 3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001145524.2 | NP_001138996.1 | protein yippee-like 3 isoform 2 |
NM_031477.4 | NP_113665.3 | protein yippee-like 3 isoform 1 |
NM_001145524.1 | NP_001138996.1 | protein yippee-like 3 isoform 2 |
NM_031477.5 | NP_113665.3 | protein yippee-like 3 isoform 1 |
Bos taurus (cattle) | YPEL3 | NP_001192338.1 |
Eremothecium gossypii | AGOS_ABR153C | NP_983101.1 |
Arabidopsis thaliana (thale cress) | AT3G11230 | NP_566389.1 |
LOC708740 | XP_001108654.1 | |
Caenorhabditis elegans (roundworm) | F37A8.5 | NP_497796.1 |
Kluyveromyces lactis | KLLA0E05875g | XP_454211.1 |
Schizosaccharomyces pombe (fission yeast) | SPAPJ691.02 | NP_594895.1 |
Pan troglodytes (chimpanzee) | YPEL3 | XP_003952871.1 |
Canis lupus familiaris (dog) | YPEL3 | XP_003434860.2 |
Neurospora crassa | NCU00024 | XP_957011.1 |
Homo sapiens (human) | YPEL3 | NP_113665.3 |
Mus musculus (house mouse) | Ypel3 | NP_079623.1 |
Rattus norvegicus (Norway rat) | Ypel3 | NP_001129170.1 |
Danio rerio (zebrafish) | LOC561851 | XP_690346.1 |
Saccharomyces cerevisiae (baker's yeast) | MOH1 | NP_009504.1 |
YPEL3 suppresses epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway.
Zhang J, Wen X, Ren XY, Li YQ, Tang XR, Wang YQ, He QM, Yang XJ, Sun Y, Liu N, Ma J
Journal of experimental & clinical cancer research : CR35(1)109(2016 Jul)
Biological insights from 108 schizophrenia-associated genetic loci.
Nature511(7510)421-7(2014 Jul)
Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence.
Tuttle R, Miller KR, Maiorano JN, Termuhlen PM, Gao Y, Berberich SJ
International journal of cancer130(10)2291-9(2012 May)
Senescence-associated gene YPEL3 is downregulated in human colon tumors.
Tuttle R, Simon M, Hitch DC, Maiorano JN, Hellan M, Ouellette J, Termuhlen P, Berberich SJ
Annals of surgical oncology18(6)1791-6(2011 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that YPEL3 is downregulated in nasopharyngeal carcinoma (NPC) cell lines and tissue samples and it suppresses NPC EMT and metastasis by suppressing the Wnt/beta-catenin signaling pathway.
Title: YPEL3 suppresses epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway.
YPEL3 expression, which is induced by the removal of estrogen or treatment with tamoxifen triggers cellular senescence in MCF-7 cells while loss of YPEL3 increases the growth rate of MCF-7 cells.
Title: Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence.
YPEL3 is downregulated in colon tumors.
Title: Senescence-associated gene YPEL3 is downregulated in human colon tumors.
Observational study of gene-disease association. (HuGE Navigator)
Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
In this review we show that transcriptionally active forms of p73 and p63, family members of p53, can transactivate the human YPEL3 gene[review]
Title: Why YPEL3 represents a novel tumor suppressor.
The following YPEL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YPEL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu02697 | |
Clone ID Related Accession (Same CDS sequence) | NM_001145524.2 , NM_001145524.1 | |
Accession Version | NM_001145524.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | protein yippee-like 3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB098737.1 and AC012645.7. On May 31, 2019 this sequence version replaced NM_001145524.1. Transcript Variant: This variant (2) represents alternate splicing in the first exon (of variant 1) resulting in predicted use of a downstream translation start site and a shorter protein (isoform 2). ##Evidence-Data-START## Transcript exon combination :: BC005009.1, DRR138525.482183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGTGCGGA TTTCAAAGCC CAAGACGTTT CAGGCCTACT TGGATGATTG TCACCGGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001138996.1 |
CDS | 184..543 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001145524.2 |
1 | ATGGTGCGGA TTTCAAAGCC CAAGACGTTT CAGGCCTACT TGGATGATTG TCACCGGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu02697 | |
Clone ID Related Accession (Same CDS sequence) | NM_001145524.2 , NM_001145524.1 | |
Accession Version | NM_001145524.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-10-27 | |
Organism | Homo sapiens(human) | |
Product | protein yippee-like 3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB098737.1. Transcript Variant: This variant (2) represents alternate splicing in the first exon (of variant 1) resulting in predicted use of a downstream translation start site and a shorter protein (isoform 2). ##Evidence-Data-START## Transcript exon combination :: AB098737.1, AF305622.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGTGCGGA TTTCAAAGCC CAAGACGTTT CAGGCCTACT TGGATGATTG TCACCGGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001138996.1 |
CDS | 187..546 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001145524.1 |
1 | ATGGTGCGGA TTTCAAAGCC CAAGACGTTT CAGGCCTACT TGGATGATTG TCACCGGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10382 | |
Clone ID Related Accession (Same CDS sequence) | NM_031477.4 , NM_031477.5 | |
Accession Version | NM_031477.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-10-27 | |
Organism | Homo sapiens(human) | |
Product | protein yippee-like 3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC050664.1 and AC012645.7. On Nov 15, 2006 this sequence version replaced NM_031477.3. Transcript Variant: This variant (1) represents a longer transcript and longer protein isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC050664.1, AL568887.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTGTGTGG CCCAGGTCCT GACAGCCCAC CTACTCCCTC CCCGGCAGGC ACTGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_113665.3 |
CDS | 719..1192 |
Translation |
Target ORF information:
Target ORF information:
|
NM_031477.4 |
1 | ATGTGTGTGG CCCAGGTCCT GACAGCCCAC CTACTCCCTC CCCGGCAGGC ACTGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10382 | |
Clone ID Related Accession (Same CDS sequence) | NM_031477.4 , NM_031477.5 | |
Accession Version | NM_031477.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-25 | |
Organism | Homo sapiens(human) | |
Product | protein yippee-like 3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC012645.7 and BC050664.1. On May 17, 2019 this sequence version replaced NM_031477.4. Transcript Variant: This variant (1) represents a longer transcript and longer protein isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC050664.1, CA312571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000398841.6/ ENSP00000381821.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## |
1 | ATGTGTGTGG CCCAGGTCCT GACAGCCCAC CTACTCCCTC CCCGGCAGGC ACTGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_113665.3 |
CDS | 732..1205 |
Translation |
Target ORF information:
Target ORF information:
|
NM_031477.5 |
1 | ATGTGTGTGG CCCAGGTCCT GACAGCCCAC CTACTCCCTC CCCGGCAGGC ACTGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
YPEL3 suppresses epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway. |
Biological insights from 108 schizophrenia-associated genetic loci. |
Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence. |
Senescence-associated gene YPEL3 is downregulated in human colon tumors. |