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RNASEH2C cDNA ORF clone, Homo sapiens (human)

Gene Symbol RNASEH2C
Entrez Gene ID 84153
Full Name ribonuclease H2, subunit C
Synonyms AGS3, AYP1
General protein information
Preferred Names
ribonuclease H2 subunit C
Names
ribonuclease H2 subunit C
RNase H2 subunit C
RNase H1 small subunit
ribonuclease HI subunit C
aicardi-Goutieres syndrome 3 protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13.1

Summary This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

610330

Disorder Html: Aicardi-Goutieres syndrome 3, 610329 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_032193 NP_115569 ribonuclease H2 subunit C



Homo sapiens (human) RNASEH2C NP_115569.2
Pan troglodytes (chimpanzee) RNASEH2C XP_508559.3
Macaca mulatta (Rhesus monkey) LOC701279 XP_001089023.1
Macaca mulatta (Rhesus monkey) RNASEH2C XP_001085695.1
Canis lupus familiaris (dog) RNASEH2C XP_852826.1
Bos taurus (cattle) RNASEH2C NP_001039386.1
Mus musculus (house mouse) Rnaseh2c NP_080892.1
Rattus norvegicus (Norway rat) Rnaseh2c XP_002728902.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RNASEH2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASEH2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20612
NM_032193 Homo sapiens ribonuclease H2, subunit C (RNASEH2C), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20612
Clone ID Related Accession (Same CDS sequence) NM_032193
Accession Version NM_032193.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 495bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product ribonuclease H2 subunit C
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF346606.1, BC023588.2, AP001266.4 and BC000831.1. This sequence is a reference standard in the RefSeqGene project. On Aug 25, 2006 this sequence version replaced gi:38176284. ##Evidence-Data-START## Transcript exon combination :: AF346606.1, BX353248.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA 
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG
GTGCCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_115569.2
CDS181..675
Misc Feature(1)64..66(+)
Misc Feature(2)181..183(+)
Misc Feature(3)268..585(+)
Misc Feature(4)268..432(+)
Exon (1)1..352
Gene:RNASEH2C
Gene Synonym:
Exon (2)353..528
Gene:RNASEH2C
Gene Synonym:
Exon (3)529..648
Gene:RNASEH2C
Gene Synonym:
Exon (4)649..2785
Gene:RNASEH2C
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_032193
Organism Homo sapiens (human)
Definition Homo sapiens ribonuclease H2, subunit C (RNASEH2C), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032193

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA 
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG
GTGCCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

New loci associated with kidney function and chronic kidney disease
Nat. Genet. 42 (5), 376-384 (2010)
Kottgen A, Pattaro C, Boger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Pare G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tonjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstatter A, Kollerits B, Kedenko L, Magi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Volzke H, Kroemer HK, Nauck M, Volker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Kramer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM and Fox CS.


book

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex
Nucleic Acids Res. 37 (1), 96-110 (2009)
Chon H, Vassilev A, DePamphilis ML, Zhao Y, Zhang J, Burgers PM, Crouch RJ and Cerritelli SM.


book

Clinical and molecular phenotype of Aicardi-Goutieres syndrome
Am. J. Hum. Genet. 81 (4), 713-725 (2007)
Rice G, Patrick T, Parmar R, Taylor CF, Aeby A, Aicardi J, Artuch R, Montalto SA, Bacino CA, Barroso B, Baxter P, Benko WS, Bergmann C, Bertini E, Biancheri R, Blair EM, Blau N, Bonthron DT, Briggs T, Brueton LA, Brunner HG, Burke CJ, Carr IM, Carvalho DR, Chandler KE, Christen HJ, Corry PC, Cowan FM, Cox H, D'Arrigo S, Dean J, De Laet C, De Praeter C, Dery C, Ferrie CD, Flintoff K, Frints SG, Garcia-Cazorla A, Gener B, Goizet C, Goutieres F, Green AJ, Guet A, Hamel BC, Hayward BE, Heiberg A, Hennekam RC, Husson M, Jackson AP, Jayatunga R, Jiang YH, Kant SG, Kao A, King MD, Kingston HM, Klepper J, van der Knaap MS, Kornberg AJ, Kotzot D, Kratzer W, Lacombe D, Lagae L, Landrieu PG, Lanzi G, Leitch A, Lim MJ, Livingston JH, Lourenco CM, Lyall EG, Lynch SA, Lyons MJ, Marom D, McClure JP, McWilliam R, Melancon SB, Mewasingh LD, Moutard ML, Nischal KK, Ostergaard JR, Prendiville J, Rasmussen M, Rogers RC, Roland D, Rosser EM, Rostasy K, Roubertie A, Sanchis A, Schiffmann R, Scholl-Burgi S, Seal S, Shalev SA, Corcoles CS, Sinha GP, Soler D, Spiegel R, Stephenson JB, Tacke U, Tan TY, Till M, Tolmie JL, Tomlin P, Vagnarelli F, Valente EM, Van Coster RN, Van der Aa N, Vanderver A, Vles JS, Voit T, Wassmer E, Weschke B, Whiteford ML, Willemsen MA, Zankl A, Zuberi SM, Orcesi S, Fazzi E, Lebon P and Crow YJ.


book

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection
Nat. Genet. 38 (8), 910-916 (2006)
Crow YJ, Leitch A, Hayward BE, Garner A, Parmar R, Griffith E, Ali M, Semple C, Aicardi J, Babul-Hirji R, Baumann C, Baxter P, Bertini E, Chandler KE, Chitayat D, Cau D, Dery C, Fazzi E, Goizet C, King MD, Klepper J, Lacombe D, Lanzi G, Lyall H, Martinez-Frias ML, Mathieu M, McKeown C, Monier A, Oade Y, Quarrell OW, Rittey CD, Rogers RC, Sanchis A, Stephenson JB, Tacke U, Till M, Tolmie JL, Tomlin P, Voit T, Weschke B, Woods CG, Lebon P, Bonthron DT, Ponting CP and Jackson AP.


book

Evidence that the SRY protein is encoded by a single exon on the human Y chromosome
Genomics 17 (3), 736-739 (1993)
Behlke MA, Bogan JS, Beer-Romero P and Page DC.


book

Aicardi-Goutieres Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Crow,Y.J.


 
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