Gene Symbol | FAM220A |
Entrez Gene ID | 84792 |
Full Name | family with sequence similarity 220 member A |
Synonyms | ACPIN1,C7orf70,SIPAR |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » FAM220A cDNA ORF clone
Gene Symbol | FAM220A |
Entrez Gene ID | 84792 |
Full Name | family with sequence similarity 220 member A |
Synonyms | ACPIN1,C7orf70,SIPAR |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001037163.1 | NP_001032240.1 | protein FAM220A |
NM_001037163.2 | NP_001032240.1 | protein FAM220A |
Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP.
Ren F, Geng Y, Minami T, Qiu Y, Feng Y, Liu C, Zhao J, Wang Y, Fan X, Wang Y, Li M, Li J, Chang Z
FEBS letters589(15)1890-6(2015 Jul)
SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma.
Ren F, Su F, Ning H, Wang Y, Geng Y, Feng Y, Wang Y, Zhang Y, Jin Z, Li Y, Jia B, Chang Z
Cellular signalling25(11)2272-80(2013 Nov)
Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein.
Ueda T, Manabe H, Tokuhiro K, Hirose M, Matsuoka Y, Miyagawa Y, Tsujimura A, Fujita K, Wada M, Okuyama A, Nishimune Y, Tanaka H
International journal of urology : official journal of the Japanese Urological Association16(7)639-46(2009 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus
Title: Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP.
The following FAM220A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FAM220A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu30911 | |
Clone ID Related Accession (Same CDS sequence) | NM_001037163.1 , NM_001037163.2 | |
Accession Version | NM_001037163.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | protein FAM220A | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP354450.1 and AF533707.1. On or before Mar 4, 2006 this sequence version replaced XM_930588.1, XM_942732.1, XM_935791.1. ##Evidence-Data-START## Transcript exon combination :: AF533707.1, BC142977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGGGACA GAAGAGGGCC CCTCGGCACC TGCCTGGCAC AAGTGCAGCA GGCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001032240.1 |
CDS | 469..1248 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001037163.1 |
1 | ATGAGGGACA GAAGAGGGCC CCTCGGCACC TGCCTGGCAC AAGTGCAGCA GGCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30911 | |
Clone ID Related Accession (Same CDS sequence) | NM_001037163.1 , NM_001037163.2 | |
Accession Version | NM_001037163.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-30 | |
Organism | Homo sapiens(human) | |
Product | protein FAM220A | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009412.6, BP354450.1 and AF533707.1. On Nov 22, 2018 this sequence version replaced NM_001037163.1. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.450904.1, SRR3476690.81585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000313324.9/ ENSP00000317289.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGAGGGACA GAAGAGGGCC CCTCGGCACC TGCCTGGCAC AAGTGCAGCA GGCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001032240.1 |
CDS | 477..1256 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001037163.2 |
1 | ATGAGGGACA GAAGAGGGCC CCTCGGCACC TGCCTGGCAC AAGTGCAGCA GGCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. |
SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. |
Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein. |