Gene Symbol | EIF3F |
Entrez Gene ID | 8665 |
Full Name | eukaryotic translation initiation factor 3 subunit F |
Synonyms | EIF3S5,eIF3-p47 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » EIF3F cDNA ORF clone
Gene Symbol | EIF3F |
Entrez Gene ID | 8665 |
Full Name | eukaryotic translation initiation factor 3 subunit F |
Synonyms | EIF3S5,eIF3-p47 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_003754.3 | NP_003745.1 | eukaryotic translation initiation factor 3 subunit F |
NM_003754.2 | NP_003745.1 | eukaryotic translation initiation factor 3 subunit F |
Caenorhabditis elegans (roundworm) | eif-3.F | NP_495988.1 |
Neurospora crassa | NCU01021 | XP_961633.1 |
Xenopus tropicalis (tropical clawed frog) | eif3f | NP_001016190.1 |
Homo sapiens (human) | EIF3F | NP_003745.1 |
EIF3F | XP_001105893.2 | |
Drosophila melanogaster (fruit fly) | CG9769 | NP_649489.1 |
Anopheles gambiae (African malaria mosquito) | EIF3F_ANOGA | XP_311967.3 |
Pan troglodytes (chimpanzee) | EIF3F | NP_001104282.1 |
Gallus gallus (chicken) | EIF3F | XP_421624.1 |
Schizosaccharomyces pombe (fission yeast) | SPBC4C3.07 | NP_596298.1 |
Arabidopsis thaliana (thale cress) | EIF2 | NP_181528.1 |
Canis lupus familiaris (dog) | EIF3F | XP_534044.4 |
Rattus norvegicus (Norway rat) | Eif3f | NP_001264231.1 |
Danio rerio (zebrafish) | eif3f | NP_001186938.1 |
Oryza sativa (rice) | Os05g0104800 | NP_001054405.1 |
Bos taurus (cattle) | EIF3F | XP_002693111.1 |
Mus musculus (house mouse) | Eif3f | NP_079620.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_10653 | XP_003710082.1 |
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells.
Lee JY, Kim HJ, Rho SB, Lee SH
Oncotarget7(14)18541-57(2016 Apr)
The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity.
Guti?rrez-Fern?ndez MJ, Higareda-Mendoza AE, G?mez-Correa CA, Pardo-Galv?n MA
BMC biochemistry1625(2015 Oct)
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.
Lee AS, Kranzusch PJ, Cate JH
Nature522(7554)111-4(2015 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The overexpression of eIF3f suppressed Akt and ERK signaling and subsequently depleted CLU expression. In addition, eIF3F stabilized p53, which increased the expression of p21 and Bax.
Title: eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells.
eIF3f/alpha adrenergic receptor interaction
Title: The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity.
Decreased expression of eukaryotic initiation factor 3f is associated with gastric cancer.
Title: Decreased expression of eukaryotic initiation factor 3f is an adverse prognostic factor for stage I-III gastric cancer.
eIF3f may play an important role in recurrence.
Title: Expression of eukaryotic initiation factor 3f is associated with prognosis in gastric carcinomas.
findings established a new mechanism of rRNA decay regulation mediated by hnRNP K/eIF3f and suggest that the tumor suppressive function of eIF3f may link to impaired rRNA degradation and translation
Title: The tumor suppressive role of eIF3f and its function in translation inhibition and rRNA degradation.
The following EIF3F gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF3F cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu30197 | |
Clone ID Related Accession (Same CDS sequence) | NM_003754.3 , NM_003754.2 | |
Accession Version | NM_003754.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | eukaryotic translation initiation factor 3 subunit F | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from CB141463.1, U94855.1, CD050033.1, BC000490.2 and AC116456.12. On Nov 23, 2018 this sequence version replaced NM_003754.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.246689.1, SRR1660805.149226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000651655.1/ ENSP00000499218.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCCACAC CGGCGGTACC AGTAAGTGCT CCTCCGGCCA CGCCAACCCC AGTCCCGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003745.1 |
CDS | 17..1090 |
Translation |
Target ORF information:
Target ORF information:
|
NM_003754.3 |
1 | ATGGCCACAC CGGCGGTACC AGTAAGTGCT CCTCCGGCCA CGCCAACCCC AGTCCCGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30197 | |
Clone ID Related Accession (Same CDS sequence) | NM_003754.3 , NM_003754.2 | |
Accession Version | NM_003754.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | eukaryotic translation initiation factor 3 subunit F | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from CB141463.1, U94855.1, CD050033.1 and BC000490.2. On Dec 15, 2005 this sequence version replaced NM_003754.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.314276.1, SRR1163658.11948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. |
1 | ATGGCCACAC CGGCGGTACC AGTAAGTGCT CCTCCGGCCA CGCCAACCCC AGTCCCGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003745.1 |
CDS | 34..1107 |
Translation |
Target ORF information:
Target ORF information:
|
NM_003754.2 |
1 | ATGGCCACAC CGGCGGTACC AGTAAGTGCT CCTCCGGCCA CGCCAACCCC AGTCCCGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Architecture of the human interactome defines protein communities and disease networks. |
eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells. |
The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity. |
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. |