MPZL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	MPZL1
Entrez Gene ID	9019
Full Name	myelin protein zero like 1
Synonyms	MPZL1b,PZR,PZR1b,PZRa,PZRb
General protein information	Preferred Names myelin protein zero like 1 Names myelin protein zero-like protein 1 immunoglobulin family transmembrane protein protein zero related
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q24.2
Disorder MIM:	604376

mRNA and Protein(s)

mRNA	Protein	Name
NM_003953.5	NP_003944.1	myelin protein zero-like protein 1 isoform a precursor
NM_024569.5	NP_078845.3	myelin protein zero-like protein 1 isoform b precursor
NM_024569.4	NP_078845.3	myelin protein zero-like protein 1 isoform b precursor
NM_003953.6	NP_003944.1	myelin protein zero-like protein 1 isoform a precursor
NM_001146191.2	NP_001139663.1	myelin protein zero-like protein 1 isoform c precursor
NM_001146191.1	NP_001139663.1	myelin protein zero-like protein 1 isoform c precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MPZL1	XP_524952.3
Bos taurus (cattle)	MPZL1	NP_001069626.1
Mus musculus (house mouse)	Mpzl1	NP_001077366.1
Gallus gallus (chicken)	MPZL1	XP_416652.4
Canis lupus familiaris (dog)	MPZL1	XP_537211.3
Rattus norvegicus (Norway rat)	Mpzl1	NP_001007729.1
Xenopus tropicalis (tropical clawed frog)	mpzl1	XP_004912325.1
	MPZL1	XP_001089242.1
Danio rerio (zebrafish)	mpzl1l	NP_001244269.1
Homo sapiens (human)	MPZL1	NP_003944.1

Gene Ontology
Bibliography

Related articles in PubMed

MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells.
Beigbeder A, Chartier FJM, Bisson N
Scientific reports7(1)11514(2017 Sep)

Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma.
Jia D, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X
Cell research24(2)204-17(2014 Feb)

Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.
Cummings AC, Jiang L, Velez Edwards DR, McCauley JL, Laux R, McFarland LL, Fuzzell D, Knebusch C, Caywood L, Reinhart-Mercer L, Nations L, Gilbert JR, Konidari I, Tramontana M, Cuccaro ML, Scott WK, Pericak-Vance MA, Haines JL
Annals of human genetics76(5)342-51(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MPZL1 is a target gene within the 1q24.1-24.2 amplicon that plays a pivotal role in HCC cell migration and tumor metastasis, and a novel MPZL1/Src/cortactin signaling cascade.
Title: Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.

Clinico-electrophysiological features and MRI findings are described in leg musculature from three patients belonging to a CMT2J pedigree due to MPZ Thr124Met mutation.
Title: Charcot?Marie?Tooth disease type 2J with MPZ Thr124Met mutation: clinico-electrophysiological and MRI study of a family.

Observational study of gene-disease association. (HuGE Navigator)
Title: Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.

The following MPZL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MPZL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31872	NM_003953.6 Latest version!	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu31732	NM_001146191.2 Latest version!	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu32015	NM_024569.5 Latest version!	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu32015	NM_024569.4	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu31872	NM_003953.5	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu31732	NM_001146191.1	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MPZL1 ( NM_003953.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003944.1 Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31872
Clone ID Related Accession (Same CDS sequence)	NM_003953.5 , NM_003953.6
Accession Version	NM_003953.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	myelin protein zero-like protein 1 isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA725074.1, AY359019.1, Z99943.1 and AW292498.1. On Apr 1, 2009 this sequence version replaced NM_003953.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.20133.1, AK075334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGTT TTTCCACTAC TCCCAAGGGC AAGTGTACCT TGGGAATTAT 
CCACCATTTA AAGACAGAAT CAGCTGGGCT GGAGACCTTG ACAAGAAAGA TGCATCAATC 
AACATAGAAA ATATGCAGTT TATACACAAT GGCACCTATA TCTGTGATGT CAAAAACCCT 
CCTGACATCG TTGTCCAGCC TGGACACATT AGGCTCTATG TCGTAGAAAA AGAGAATTTG 
CCTGTGTTTC CAGTTTGGGT AGTGGTGGGC ATAGTTACTG CTGTGGTCCT AGGTCTCACT 
CTGCTCATCA GCATGATTCT GGCTGTCCTC TATAGAAGGA AAAACTCTAA ACGGGATTAC 
ACTGGCTGCA GTACATCAGA GAGTTTGTCA CCAGTTAAGC AGGCTCCTCG GAAGTCCCCC 
TCCGACACTG AGGGTCTTGT AAAGAGTCTG CCTTCTGGAT CTCACCAGGG CCCAGTCATA 
TATGCACAGT TAGACCACTC CGGCGGACAT CACAGTGACA AGATTAACAA GTCAGAGTCT 
GTGGTGTATG CGGATATCCG AAAGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003944.1
CDS	203..1012
Translation	MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN

Target ORF information:

RefSeq Version	NM_003953.5
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003953.5

ORF Insert Sequence:

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGTT TTTCCACTAC TCCCAAGGGC AAGTGTACCT TGGGAATTAT 
CCACCATTTA AAGACAGAAT CAGCTGGGCT GGAGACCTTG ACAAGAAAGA TGCATCAATC 
AACATAGAAA ATATGCAGTT TATACACAAT GGCACCTATA TCTGTGATGT CAAAAACCCT 
CCTGACATCG TTGTCCAGCC TGGACACATT AGGCTCTATG TCGTAGAAAA AGAGAATTTG 
CCTGTGTTTC CAGTTTGGGT AGTGGTGGGC ATAGTTACTG CTGTGGTCCT AGGTCTCACT 
CTGCTCATCA GCATGATTCT GGCTGTCCTC TATAGAAGGA AAAACTCTAA ACGGGATTAC 
ACTGGCTGCA GTACATCAGA GAGTTTGTCA CCAGTTAAGC AGGCTCCTCG GAAGTCCCCC 
TCCGACACTG AGGGTCTTGT AAAGAGTCTG CCTTCTGGAT CTCACCAGGG CCCAGTCATA 
TATGCACAGT TAGACCACTC CGGCGGACAT CACAGTGACA AGATTAACAA GTCAGAGTCT 
GTGGTGTATG CGGATATCCG AAAGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZL1 ( NM_003953.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_003944.1 Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31872
Clone ID Related Accession (Same CDS sequence)	NM_003953.5 , NM_003953.6
Accession Version	NM_003953.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	myelin protein zero-like protein 1 isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA725074.1, AY359019.1, Z99943.1 and AW292498.1. On Nov 22, 2018 this sequence version replaced NM_003953.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075334.1, SRR1660805.14382.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359523.7/ ENSP00000352513.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGTT TTTCCACTAC TCCCAAGGGC AAGTGTACCT TGGGAATTAT 
CCACCATTTA AAGACAGAAT CAGCTGGGCT GGAGACCTTG ACAAGAAAGA TGCATCAATC 
AACATAGAAA ATATGCAGTT TATACACAAT GGCACCTATA TCTGTGATGT CAAAAACCCT 
CCTGACATCG TTGTCCAGCC TGGACACATT AGGCTCTATG TCGTAGAAAA AGAGAATTTG 
CCTGTGTTTC CAGTTTGGGT AGTGGTGGGC ATAGTTACTG CTGTGGTCCT AGGTCTCACT 
CTGCTCATCA GCATGATTCT GGCTGTCCTC TATAGAAGGA AAAACTCTAA ACGGGATTAC 
ACTGGCTGCA GTACATCAGA GAGTTTGTCA CCAGTTAAGC AGGCTCCTCG GAAGTCCCCC 
TCCGACACTG AGGGTCTTGT AAAGAGTCTG CCTTCTGGAT CTCACCAGGG CCCAGTCATA 
TATGCACAGT TAGACCACTC CGGCGGACAT CACAGTGACA AGATTAACAA GTCAGAGTCT 
GTGGTGTATG CGGATATCCG AAAGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003944.1
CDS	171..980
Translation	MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN

Target ORF information:

RefSeq Version	NM_003953.6
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003953.6

ORF Insert Sequence:

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGTT TTTCCACTAC TCCCAAGGGC AAGTGTACCT TGGGAATTAT 
CCACCATTTA AAGACAGAAT CAGCTGGGCT GGAGACCTTG ACAAGAAAGA TGCATCAATC 
AACATAGAAA ATATGCAGTT TATACACAAT GGCACCTATA TCTGTGATGT CAAAAACCCT 
CCTGACATCG TTGTCCAGCC TGGACACATT AGGCTCTATG TCGTAGAAAA AGAGAATTTG 
CCTGTGTTTC CAGTTTGGGT AGTGGTGGGC ATAGTTACTG CTGTGGTCCT AGGTCTCACT 
CTGCTCATCA GCATGATTCT GGCTGTCCTC TATAGAAGGA AAAACTCTAA ACGGGATTAC 
ACTGGCTGCA GTACATCAGA GAGTTTGTCA CCAGTTAAGC AGGCTCCTCG GAAGTCCCCC 
TCCGACACTG AGGGTCTTGT AAAGAGTCTG CCTTCTGGAT CTCACCAGGG CCCAGTCATA 
TATGCACAGT TAGACCACTC CGGCGGACAT CACAGTGACA AGATTAACAA GTCAGAGTCT 
GTGGTGTATG CGGATATCCG AAAGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZL1 ( NM_001146191.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139663.1 Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu31732
Clone ID Related Accession (Same CDS sequence)	NM_001146191.2 , NM_001146191.1
Accession Version	NM_001146191.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	myelin protein zero-like protein 1 isoform c precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK297112.1, Z99943.1 and AW292498.1. On May 31, 2019 this sequence version replaced NM_001146191.1. Transcript Variant: This variant (3) lacks three alternate exons in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.106911.1, BC000984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGGG CCCAGTCATA TATGCACAGT TAGACCACTC CGGCGGACAT 
CACAGTGACA AGATTAACAA GTCAGAGTCT GTGGTGTATG CGGATATCCG AAAGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139663.1
CDS	171..530
Translation	MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN

Target ORF information:

RefSeq Version	NM_001146191.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001146191.2

ORF Insert Sequence:

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGGG CCCAGTCATA TATGCACAGT TAGACCACTC CGGCGGACAT 
CACAGTGACA AGATTAACAA GTCAGAGTCT GTGGTGTATG CGGATATCCG AAAGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZL1 ( NM_001146191.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139663.1 Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu31732
Clone ID Related Accession (Same CDS sequence)	NM_001146191.2 , NM_001146191.1
Accession Version	NM_001146191.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	myelin protein zero-like protein 1 isoform c precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA725074.1, AK297112.1, Z99943.1 and AW292498.1. Transcript Variant: This variant (3) lacks three alternate exons in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000984.1, SRR1803617.106911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGGG CCCAGTCATA TATGCACAGT TAGACCACTC CGGCGGACAT 
CACAGTGACA AGATTAACAA GTCAGAGTCT GTGGTGTATG CGGATATCCG AAAGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139663.1
CDS	203..562
Translation	MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN

Target ORF information:

RefSeq Version	NM_001146191.1
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001146191.1

ORF Insert Sequence:

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGGG CCCAGTCATA TATGCACAGT TAGACCACTC CGGCGGACAT 
CACAGTGACA AGATTAACAA GTCAGAGTCT GTGGTGTATG CGGATATCCG AAAGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZL1 ( NM_024569.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_078845.3 Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu32015
Clone ID Related Accession (Same CDS sequence)	NM_024569.5 , NM_024569.4
Accession Version	NM_024569.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	myelin protein zero-like protein 1 isoform b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA725074.1, AF478447.1, Z99943.1 and AW292498.1. On May 31, 2019 this sequence version replaced NM_024569.4. Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.126625.1, SRR7346977.1833253.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGTT TTTCCACTAC TCCCAAGGGC AAGTGTACCT TGGGAATTAT 
CCACCATTTA AAGACAGAAT CAGCTGGGCT GGAGACCTTG ACAAGAAAGA TGCATCAATC 
AACATAGAAA ATATGCAGTT TATACACAAT GGCACCTATA TCTGTGATGT CAAAAACCCT 
CCTGACATCG TTGTCCAGCC TGGACACATT AGGCTCTATG TCGTAGAAAA AGAGAATTTG 
CCTGTGTTTC CAGTTTGGGT AGTGGTGGGC ATAGTTACTG CTGTGGTCCT AGGTCTCACT 
CTGCTCATCA GCATGATTCT GGCTGTCCTC TATAGAAGGA AAAACTCTAA ACGGGATTAC 
ACTGGGGCCC AGTCATATAT GCACAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078845.3
CDS	171..800
Translation	MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGAQSYMHS

Target ORF information:

RefSeq Version	NM_024569.5
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024569.5

ORF Insert Sequence:

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGTT TTTCCACTAC TCCCAAGGGC AAGTGTACCT TGGGAATTAT 
CCACCATTTA AAGACAGAAT CAGCTGGGCT GGAGACCTTG ACAAGAAAGA TGCATCAATC 
AACATAGAAA ATATGCAGTT TATACACAAT GGCACCTATA TCTGTGATGT CAAAAACCCT 
CCTGACATCG TTGTCCAGCC TGGACACATT AGGCTCTATG TCGTAGAAAA AGAGAATTTG 
CCTGTGTTTC CAGTTTGGGT AGTGGTGGGC ATAGTTACTG CTGTGGTCCT AGGTCTCACT 
CTGCTCATCA GCATGATTCT GGCTGTCCTC TATAGAAGGA AAAACTCTAA ACGGGATTAC 
ACTGGGGCCC AGTCATATAT GCACAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MPZL1 ( NM_024569.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078845.3 Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 2, mRNA.

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CloneID	OHu32015
Clone ID Related Accession (Same CDS sequence)	NM_024569.5 , NM_024569.4
Accession Version	NM_024569.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	myelin protein zero-like protein 1 isoform b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA725074.1, AF478447.1, Z99943.1 and AW292498.1. On Apr 1, 2009 this sequence version replaced NM_024569.3. Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.183306.1, SRR1803616.256360.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGTT TTTCCACTAC TCCCAAGGGC AAGTGTACCT TGGGAATTAT 
CCACCATTTA AAGACAGAAT CAGCTGGGCT GGAGACCTTG ACAAGAAAGA TGCATCAATC 
AACATAGAAA ATATGCAGTT TATACACAAT GGCACCTATA TCTGTGATGT CAAAAACCCT 
CCTGACATCG TTGTCCAGCC TGGACACATT AGGCTCTATG TCGTAGAAAA AGAGAATTTG 
CCTGTGTTTC CAGTTTGGGT AGTGGTGGGC ATAGTTACTG CTGTGGTCCT AGGTCTCACT 
CTGCTCATCA GCATGATTCT GGCTGTCCTC TATAGAAGGA AAAACTCTAA ACGGGATTAC 
ACTGGGGCCC AGTCATATAT GCACAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078845.3
CDS	203..832
Translation	MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGAQSYMHS

Target ORF information:

RefSeq Version	NM_024569.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myelin protein zero like 1 (MPZL1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024569.4

ORF Insert Sequence:

ATGGCAGCGT CCGCCGGAGC CGGGGCGGTG ATTGCAGCCC CAGACAGCCG GCGCTGGCTG 
TGGTCGGTGC TGGCGGCGGC GCTTGGGCTC TTGACAGCTG GAGTATCAGC CTTGGAAGTA 
TATACGCCAA AAGAAATCTT CGTGGCAAAT GGTACACAAG GGAAGCTGAC CTGCAAGTTC 
AAGTCTACTA GTACGACTGG CGGGTTGACC TCAGTCTCCT GGAGCTTCCA GCCAGAGGGG 
GCCGACACTA CTGTGTCGTT TTTCCACTAC TCCCAAGGGC AAGTGTACCT TGGGAATTAT 
CCACCATTTA AAGACAGAAT CAGCTGGGCT GGAGACCTTG ACAAGAAAGA TGCATCAATC 
AACATAGAAA ATATGCAGTT TATACACAAT GGCACCTATA TCTGTGATGT CAAAAACCCT 
CCTGACATCG TTGTCCAGCC TGGACACATT AGGCTCTATG TCGTAGAAAA AGAGAATTTG 
CCTGTGTTTC CAGTTTGGGT AGTGGTGGGC ATAGTTACTG CTGTGGTCCT AGGTCTCACT 
CTGCTCATCA GCATGATTCT GGCTGTCCTC TATAGAAGGA AAAACTCTAA ACGGGATTAC 
ACTGGGGCCC AGTCATATAT GCACAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells.
Scientific reports7(1)11514(2017 Sep)
Beigbeder A,Chartier FJM,Bisson N

Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma.
Cell research24(2)204-17(2014 Feb)
Jia D,Jing Y,Zhang Z,Liu L,Ding J,Zhao F,Ge C,Wang Q,Chen T,Yao M,Li J,Gu J,He X

Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.
Annals of human genetics76(5)342-51(2012 Sep)
Cummings AC,Jiang L,Velez Edwards DR,McCauley JL,Laux R,McFarland LL,Fuzzell D,Knebusch C,Caywood L,Reinhart-Mercer L,Nations L,Gilbert JR,Konidari I,Tramontana M,Cuccaro ML,Scott WK,Pericak-Vance MA,Haines JL

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MPZL1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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