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GDF3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GDF3
Entrez Gene ID 9573
Full Name growth differentiation factor 3
Synonyms KFS3,MCOP7,MCOPCB6
General protein information
Preferred Names

growth differentiation factor 3

Names

growth/differentiation factor 3

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

12

12p13.31

Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016].
Disorder MIM:

606522

Disorder Html: Klippel-Feil syndrome 3, autosomal dominant, 613702 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_020634.2 NP_065685.1 growth/differentiation factor 3 preproprotein
NM_020634.1 NP_065685.1 growth/differentiation factor 3 precursor



Mus musculus (house mouse) Gdf3 NP_032134.2
Danio rerio (zebrafish) dvr1 NP_571023.1
Bos taurus (cattle) GDF3 XP_002687893.1
Xenopus tropicalis (tropical clawed frog) gdf1 NP_001016819.1
Gallus gallus (chicken) GDF3 NP_990542.1
Xenopus tropicalis (tropical clawed frog) gdf3 NP_001007905.1
Macaca mulatta (rhesus monkey) GDF3 XP_001112644.1
Pan troglodytes (chimpanzee) GDF3 XP_508988.2
Canis lupus familiaris (dog) GDF3 XP_534896.1
Rattus norvegicus (Norway rat) Gdf3 NP_001103141.1
Homo sapiens (human) GDF3 NP_065685.1


Related articles in PubMed

Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells.
Han MH, Park SW, Do HJ, Chung HJ, Song H, Kim JH, Kim NH, Park KH, Kim JH
Biological & pharmaceutical bulletin39(11)1802-1808(2016)

A novel variation of GDF3 in Chinese Han children with a broad phenotypic spectrum of non-syndromic CHDs.
Xiao J, Kang G, Wang J, Li T, Chen J, Wang J, Li W, Wang B
Cardiology in the young25(7)1263-7(2015 Oct)

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Del-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums JG, Bailey K, Gong Y, Turner ST, Johnson JA, Boerwinkle E
The pharmacogenomics journal14(1)35-40(2014 Feb)

Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells.
Park SW, Lim HY, Do HJ, Sung B, Huh SH, Uhm SJ, Song H, Chung HJ, Kim JH, Kim NH, Kim JH
FEBS letters586(19)3529-35(2012 Sep)

GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.
Li Q, Ling Y, Yu L
Journal of cancer research and clinical oncology138(6)1073-9(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

OCT4 plays a role as a transcriptional activator for GDF3 transcription in pluripotent human embryonic carcinoma NCCIT cells and contributes to the understanding of the molecular networks of stem cell regulators in germ cell-derived pluripotency and tumorigenesis.
Title: Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells.

The results expand the spectrum of mutations associated with CHDs and first suggest the potentially disease-related GDF3 gene variant in the pathogenesis of CHDs.
Title: A novel variation of GDF3 in Chinese Han children with a broad phenotypic spectrum of non-syndromic CHDs.

first evidence that NANOG is a transcriptional activator of the expression of the oncogenic growth factor GDF3 in embryonic carcinoma cells
Title: Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells.

GDF3 expression level was significantly down-regulated in breast cancer tissues compared to the surrounding nontumorous tissues.
Title: GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.

Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.
Title: Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.

The following GDF3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18012
NM_020634.2
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Homo sapiens growth differentiation factor 3 (GDF3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
View Old Accession Versions >>
OHu18012
NM_020634.1 Homo sapiens growth differentiation factor 3 (GDF3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18012
Clone ID Related Accession (Same CDS sequence) NM_020634.2 , NM_020634.1
Accession Version NM_020634.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1095bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-24
Organism Homo sapiens(Human)
Product growth/differentiation factor 3 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358875.1, AF263538.1 and AA926805.1. This sequence is a reference standard in the RefSeqGene project. On Sep 1, 2016 this sequence version replaced NM_020634.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358875.1, BC030959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_065685.1
CDS66..1160
Misc Feature(1)6..8
Misc Feature(2)<390..725
Misc Feature(3)855..1157
Exon (1)1..333
Exon (2)334..1256
Translation

Target ORF information:

RefSeq Version NM_020634.2
Organism Homo sapiens(Human)
Definition Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_020634.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18012
Clone ID Related Accession (Same CDS sequence) NM_020634.2 , NM_020634.1
Accession Version NM_020634.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1095bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product growth/differentiation factor 3 precursor
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_065685.1
Translation

Target ORF information:

RefSeq Version NM_020634.1
Organism Homo sapiens(Human)
Definition Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_020634.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells.
Biological & pharmaceutical bulletin39(11)1802-1808(2016)
Han MH,Park SW,Do HJ,Chung HJ,Song H,Kim JH,Kim NH,Park KH,Kim JH


book

A novel variation of GDF3 in Chinese Han children with a broad phenotypic spectrum of non-syndromic CHDs.
Cardiology in the young25(7)1263-7(2015 Oct)
Xiao J,Kang G,Wang J,Li T,Chen J,Wang J,Li W,Wang B


book

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
The pharmacogenomics journal14(1)35-40(2014 Feb)
Del-Aguila JL,Beitelshees AL,Cooper-Dehoff RM,Chapman AB,Gums JG,Bailey K,Gong Y,Turner ST,Johnson JA,Boerwinkle E


book

Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells.
FEBS letters586(19)3529-35(2012 Sep)
Park SW,Lim HY,Do HJ,Sung B,Huh SH,Uhm SJ,Song H,Chung HJ,Kim JH,Kim NH,Kim JH


book

GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.
Journal of cancer research and clinical oncology138(6)1073-9(2012 Jun)
Li Q,Ling Y,Yu L


 
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