×

GDF3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GDF3
Entrez Gene ID 9573
Full Name growth differentiation factor 3
Synonyms KFS3, MCOP7, MCOPCB6
General protein information
Preferred Names
growth/differentiation factor 3
Names
growth/differentiation factor 3
GDF-3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13.1

Summary The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

606522

Disorder Html: Klippel-Feil syndrome 3, autosomal dominant, 613702 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_020634 NP_065685 growth/differentiation factor 3 precursor


Homo sapiens (human) GDF3 NP_065685.1
Pan troglodytes (chimpanzee) GDF3 XP_508988.2
Macaca mulatta (Rhesus monkey) GDF3 XP_001112644.1
Canis lupus familiaris (dog) GDF3 XP_534896.1
Bos taurus (cattle) GDF3 XP_002687893.1
Mus musculus (house mouse) Gdf3 NP_032134.2
Rattus norvegicus (Norway rat) Gdf3 NP_001103141.1
Gallus gallus (chicken) GDF3 NP_990542.1
Danio rerio (zebrafish) dvr1 NP_571023.1
Xenopus (Silurana) tropicalis (western clawed frog) gdf3 NP_001007905.1
Xenopus (Silurana) tropicalis (western clawed frog) gdf1 NP_001016819.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GDF3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Free ORF Clone
for Every Scientist
More Detail >>

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18012
NM_020634 Homo sapiens growth differentiation factor 3 (GDF3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18012
Clone ID Related Accession (Same CDS sequence) NM_020634
Accession Version NM_020634.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1095bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product growth/differentiation factor 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF263538.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF263538.1, AY358875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_065685.1
CDS37..1131
Misc Feature(1)103..747(+)
Misc Feature(2)826..1128(+)
Exon (1)1..304
Gene:GDF3
Gene Synonym:
Exon (2)305..1224
Gene:GDF3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_020634
Organism Homo sapiens (human)
Definition Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_020634

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans
Pharmacogenomics J. 14 (1), 35-40 (2014)
Del-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums JG, Bailey K, Gong Y, Turner ST, Johnson JA and Boerwinkle E.


book

Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells
FEBS Lett. 586 (19), 3529-3535 (2012)
Park SW, Lim HY, Do HJ, Sung B, Huh SH, Uhm SJ, Song H, Chung HJ, Kim JH, Kim NH and Kim JH.


book

GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol
J. Cancer Res. Clin. Oncol. 138 (6), 1073-1079 (2012)
Li Q, Ling Y and Yu L.


book

Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells
Fertil. Steril. 97 (4), 979-983 (2012)
Shi J, Yoshino O, Osuga Y, Akiyama I, Harada M, Koga K, Fujimoto A, Yano T and Taketani Y.


book

The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells
Mol. Cell. Biochem. 359 (1-2), 115-123 (2012)
Li Q, Liu X, Wu Y, An J, Hexige S, Ling Y, Zhang M, Yang X and Yu L.


book

Expression pattern of growth/differentiation factor 3 in human and murine cerebral cortex, hippocampus as well as cerebellum
Neurosci. Lett. 389 (2), 83-87 (2005)
Hexige S, Guo J, Ma L, Sun Y, Liu X, Ma L, Yan X, Li Z and Yu L.


book

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment
Genome Res. 13 (10), 2265-2270 (2003)
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P and Gray A.


book

The family of bone morphogenetic proteins
Kidney Int. 57 (6), 2207-2214 (2000)
Ducy P and Karsenty G.


book

Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours
Oncogene 16 (1), 95-103 (1998)
Caricasole AA, van Schaik RH, Zeinstra LM, Wierikx CD, van Gurp RJ, van den Pol M, Looijenga LH, Oosterhuis JW, Pera MF, Ward A, de Bruijn D, Kramer P, de Jong FH and van den Eijnden-van Raaij AJ.


book

GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines
J. Biol. Chem. 268 (5), 3444-3449 (1993)
McPherron AC and Lee SJ.


 
*
*
*
*