Gene Symbol | Abraxas2 |
Entrez Gene ID | 109359 |
Full Name | BRISC complex subunit |
Synonyms | AA589499,AI853413,Abro1,C430003P19Rik,Fam175b |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Abraxas2 cDNA ORF clone
Gene Symbol | Abraxas2 |
Entrez Gene ID | 109359 |
Full Name | BRISC complex subunit |
Synonyms | AA589499,AI853413,Abro1,C430003P19Rik,Fam175b |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_198017.3 | NP_932134.3 | BRISC complex subunit Abraxas 2 |
Pan troglodytes (chimpanzee) | FAM175B | XP_003312863.1 |
Mus musculus (house mouse) | Fam175b | NP_932134.3 |
Homo sapiens (human) | FAM175B | NP_115558.3 |
LOC694886 | XP_001083977.1 | |
Canis lupus familiaris (dog) | FAM175B | XP_535051.4 |
Bos taurus (cattle) | FAM175B | NP_001160059.1 |
Rattus norvegicus (Norway rat) | Fam175b | NP_001099777.2 |
Danio rerio (zebrafish) | LOC100538340 | XP_003200403.1 |
Danio rerio (zebrafish) | fam175b | NP_998460.1 |
Xenopus tropicalis (tropical clawed frog) | fam175b | NP_001192104.1 |
Gallus gallus (chicken) | FAM175B | NP_001026412.1 |
Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.
Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B
Genes & development31(14)1469-1482(2017 Jul)
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.
Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B
Cell reports8(3)807-17(2014 Aug)
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.
Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Katlinski K, Wu J, Varghese B, Carbone CJ, Aressy B, Fuchs SY, Greenberg RA
Cell reports5(1)180-93(2013 Oct)
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
Ambivero CT, Cilenti L, Zervos AS
Biochimica et biophysica acta1823(12)2149-56(2012 Dec)
Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.
Somma G, Alger HM, McGuire RM, Kretlow JD, Ruiz FR, Yatsenko SA, Stankiewicz P, Harrison W, Funk E, Bergamaschi A, Oghalai JS, Mikos AG, Overbeek PA, Pereira FA
Journal of the Association for Research in Otolaryngology : JARO13(3)335-49(2012 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Abro1 deficiency results in increased chromosome instability, and Abro1-null mice are tumor-prone.
Title: Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.
Abraxas deficiency causes defective DNA repair, genetic instability, decreased survival and increased tumor incidence.
Title: The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.
Data shows that the expression of Abro1 protein substantially increased (at least three-fold) in the hearts of mice that underwent MI/R compared to sham operated controls.
Title: Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.
The following Abraxas2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abraxas2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu08799 | |
Clone ID Related Accession (Same CDS sequence) | NM_198017.3 | |
Accession Version | NM_198017.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Mus musculus(house mouse) | |
Product | BRISC complex subunit Abraxas 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC099627.10, AK171524.1 and AV375824.1. On Sep 23, 2011 this sequence version replaced NM_198017.2. ##Evidence-Data-START## Transcript exon combination :: AK146064.1, SRR1660817.304773.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGATGGGGG AGGTGGAGAT TTCCATCATG GCGGCTTCCA TTTCGGGCTA CACCTTCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_932134.3 |
CDS | 11..1285 |
Translation |
Target ORF information:
Target ORF information:
|
NM_198017.3 |
1 | ATGATGGGGG AGGTGGAGAT TTCCATCATG GCGGCTTCCA TTTCGGGCTA CACCTTCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. |
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. |
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. |
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway. |
Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. |