Gene Symbol | Blvra |
Entrez Gene ID | 109778 |
Full Name | biliverdin reductase A |
Synonyms | 0610006A11Rik,2500001N03Rik,Blvr |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Blvra cDNA ORF clone
Gene Symbol | Blvra |
Entrez Gene ID | 109778 |
Full Name | biliverdin reductase A |
Synonyms | 0610006A11Rik,2500001N03Rik,Blvr |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006498572.4 | XP_006498635.1 | biliverdin reductase A isoform X2 |
XM_006498572.3 | XP_006498635.1 | biliverdin reductase A isoform X2 |
XM_006498569.3 | XP_006498632.1 | biliverdin reductase A isoform X1 |
XM_030246659.1 | XP_030102519.1 | biliverdin reductase A isoform X3 |
NM_026678.4 | NP_080954.4 | biliverdin reductase A |
XM_030246651.1 | XP_030102511.1 | biliverdin reductase A isoform X2 |
XM_006498573.1 | XP_006498636.1 | biliverdin reductase A isoform X3 |
XM_006498571.3 | XP_006498634.1 | biliverdin reductase A isoform X2 |
Homo sapiens (human) | BLVRA | NP_000703.2 |
Pan troglodytes (chimpanzee) | BLVRA | XP_519058.3 |
Canis lupus familiaris (dog) | BLVRA | XP_005630976.1 |
Mus musculus (house mouse) | Blvra | NP_080954.4 |
Bos taurus (cattle) | BLVRA | NP_001091040.1 |
Rattus norvegicus (Norway rat) | Blvra | NP_446302.1 |
Gallus gallus (chicken) | BLVRA | XP_418872.3 |
Danio rerio (zebrafish) | blvra | NP_001070069.1 |
Xenopus tropicalis (tropical clawed frog) | blvra | NP_001006896.1 |
BLVRA | XP_001095668.1 |
Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress.
Chen W, Maghzal GJ, Ayer A, Suarna C, Dunn LL, Stocker R
Free radical biology & medicine115156-165(2018 Feb)
Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?.
Hinds TD Jr, Burns KA, Hosick PA, McBeth L, Nestor-Kalinoski A, Drummond HA, AlAmodi AA, Hankins MW, Vanden Heuvel JP, Stec DE
The Journal of biological chemistry291(48)25179-25191(2016 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These findings reveal a novel BVRA-GSKbeta-PPARalpha axis that regulates hepatic lipid metabolism and may provide unique targets for the treatment of non-alcoholic fatty liver disease.
Title: Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?.
BVR-A integrates both oxidative/nitrosative stress- and insulin-mediated signaling, both mechanisms dysregulated in the Alzheimer disease brain.
Title: Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm.
The biliverdin reductase A positive macrophage is a source of anti-inflammatory cytokine IL-10 in injured kidney.
Title: Biliverdin Reductase A (BVRA) Mediates Macrophage Expression of Interleukin-10 in Injured Kidney.
Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B.
Title: Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B.
biliverdin reductase has a role in regulating the inflammatory response to endotoxin that requires eNOS-derived NO and TLR4 signaling in macrophages
Title: Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase.
The following Blvra gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Blvra cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu29917 | |
Clone ID Related Accession (Same CDS sequence) | XM_030246659.1 , XM_006498573.1 | |
Accession Version | XM_006498573.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | biliverdin reductase A isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCATTGT CATTTGCGGC AGCGCAGGAG CTGTGGGAGC TGGCTGCACA GAAAGGGAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006498636.1 |
CDS | 395..988 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006498573.1 |
1 | ATGGCATTGT CATTTGCGGC AGCGCAGGAG CTGTGGGAGC TGGCTGCACA GAAAGGGAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02805 | |
Clone ID Related Accession (Same CDS sequence) | XM_006498572.4 , XM_006498572.3 , NM_026678.4 , XM_030246651.1 , XM_006498571.3 | |
Accession Version | NM_026678.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-04 | |
Organism | Mus musculus(house mouse) | |
Product | biliverdin reductase A | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY073963.1, BC052146.1 and CA983696.1. On Feb 6, 2007 this sequence version replaced NM_026678.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052146.1, AK172620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080954.4 |
CDS | 192..1079 |
Translation |
Target ORF information:
Target ORF information:
|
NM_026678.4 |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02805 | |
Clone ID Related Accession (Same CDS sequence) | XM_006498572.4 , XM_006498572.3 , NM_026678.4 , XM_030246651.1 , XM_006498571.3 | |
Accession Version | XM_006498572.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | biliverdin reductase A isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006498572.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006498635.1 |
CDS | 287..1174 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006498572.3 |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02805 | |
Clone ID Related Accession (Same CDS sequence) | XM_006498572.4 , XM_006498572.3 , NM_026678.4 , XM_030246651.1 , XM_006498571.3 | |
Accession Version | XM_006498571.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | biliverdin reductase A isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006498571.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006498634.1 |
CDS | 213..1100 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006498571.3 |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu29915 | |
Clone ID Related Accession (Same CDS sequence) | XM_006498569.3 | |
Accession Version | XM_006498569.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | biliverdin reductase A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006498569.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGAGC TCCCCCTTAC AGTGTTGACA TCTAAAGCCA GCGTGAAAAC TGTATCCATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006498632.1 |
CDS | 200..1213 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006498569.3 |
1 | ATGGCTGAGC TCCCCCTTAC AGTGTTGACA TCTAAAGCCA GCGTGAAAAC TGTATCCATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02805 | |
Clone ID Related Accession (Same CDS sequence) | XM_006498572.4 , XM_006498572.3 , NM_026678.4 , XM_030246651.1 , XM_006498571.3 | |
Accession Version | XM_006498572.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | biliverdin reductase A isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006498572.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006498635.1 |
CDS | 765..1652 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006498572.4 |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02805 | |
Clone ID Related Accession (Same CDS sequence) | XM_006498572.4 , XM_006498572.3 , NM_026678.4 , XM_030246651.1 , XM_006498571.3 | |
Accession Version | XM_030246651.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | biliverdin reductase A isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030102511.1 |
CDS | 487..1374 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030246651.1 |
1 | ATGAGTACTG AGCCAAAGAG GAAATTTGGT GTGGTAGTGG TTGGTGTTGG CAGAGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu29917 | |
Clone ID Related Accession (Same CDS sequence) | XM_030246659.1 , XM_006498573.1 | |
Accession Version | XM_030246659.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | biliverdin reductase A isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCATTGT CATTTGCGGC AGCGCAGGAG CTGTGGGAGC TGGCTGCACA GAAAGGGAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030102519.1 |
CDS | 389..982 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030246659.1 |
1 | ATGGCATTGT CATTTGCGGC AGCGCAGGAG CTGTGGGAGC TGGCTGCACA GAAAGGGAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress. |
Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. |