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Fdps cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Fdps
Entrez Gene ID 110196
Full Name farnesyl diphosphate synthetase
Synonyms 6030492I17Rik,AI256750,Fdpsl1,mKIAA1293
General protein information
Preferred Names

farnesyl diphosphate synthetase

Names

farnesyl pyrophosphate synthase
(2E,6E)-farnesyl diphosphate synthase
CR 39
FPP synthase
FPP synthetase
FPS
cholesterol-regulated 39 kDa protein
dimethylallyltranstransferase
farnesyl diphosphate synthase
farnesyl pyrophosphate synthetase
geranyltranstransferase
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

3

3 F1|3 39.01 cM

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_134469.4 NP_608219.1 farnesyl pyrophosphate synthase isoform 2
NM_001253751.1 NP_001240680.1 farnesyl pyrophosphate synthase isoform 1 precursor

Pathways from BioSystems


Homologies


Drosophila melanogaster (fruit fly) Fpps NP_477380.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP007104 XP_308653.4
Magnaporthe oryzae (rice blast fungus) MGG_08649 XP_003711082.1
Kluyveromyces lactis KLLA0A06732g XP_451300.1
Eremothecium gossypii AGOS_AEL122W NP_984739.1
Schizosaccharomyces pombe (fission yeast) fps1 NP_593299.1
Canis lupus familiaris (dog) FDPS XP_005622781.1
Bos taurus (cattle) FDPS NP_803463.1
Mus musculus (house mouse) Fdps NP_001240680.1
Rattus norvegicus (Norway rat) Fdps NP_114028.1
Danio rerio (zebrafish) fdps NP_001020642.1
Xenopus tropicalis (tropical clawed frog) fdps NP_001015867.1
Homo sapiens (human) FDPS NP_001995.1
Pan troglodytes (chimpanzee) FDPS XP_001160391.1
Gallus gallus (chicken) FDPS XP_422855.3
Saccharomyces cerevisiae (baker's yeast) ERG20 NP_012368.1
Neurospora crassa NCU01175 XP_961541.1
Arabidopsis thaliana (thale cress) FPS1 NP_199588.1
Arabidopsis thaliana (thale cress) FPS2 NP_193452.1
Oryza sativa (rice) Os05g0543400 NP_001056204.1
Oryza sativa (rice) Os01g0703400 NP_001044000.1

Gene Ontology


Bibliography

Related articles in PubMed

Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.
Lowther KM, Favero F, Yang CR, Taylor HS, Seli E
Biology of reproduction96(2)341-351(2017 02)

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
?i?ecio?lu M, Budak H, Geffers L, ?ankaya M, ?iftci M, Thaller C, Eichele G, K?frevio?lu ??, ?zdemir H
Journal of lipid research56(8)1551-9(2015 Aug)

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
Patra D, DeLassus E, Liang G, Sandell LJ
PloS one9(8)e105674(2014)

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
Yang J, Mou Y, Wu T, Ye Y, Jiang JC, Zhao CZ, Zhu HH, Du CQ, Zhou L, Hu SJ
Cardiovascular research97(3)490-9(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure.
Title: Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

identified a single putative direct repeat 4 (DR4) LXR response element in the FPS promoter isolated from immortalized murine astrocyte P11-5 cells
Title: Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.

novel role in fibroblast growth factor-mediated signal transduction
Title: A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction.

The following Fdps gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fdps cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu05586 NM_001253751.1
Latest version!		 Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $223.30
$319.00
OMu15781 NM_134469.4
Latest version!		 Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $188.30
$269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu05586
Clone ID Related Accession (Same CDS sequence) NM_001253751.1
Accession Version NM_001253751.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1263bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-21
Organism Mus musculus(house mouse)
Product farnesyl pyrophosphate synthase isoform 1 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ082322.1, BY144580.1, AC140468.2, BC048497.1 and BE994006.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGCCCCTGT CCTGCTGGCT GAGATCTCTG GGGGTCTTCC TGCTGCCAGC CCCCTGCTGG 
GCACCCCGGG AGAGGTGGCT TGGTTTCCTA CAACGACCCT CCCTGGCATA TGGGTGTCCA 
GTCCTGGGGG CCTGGCACAG TGCCCGCTGG TGGTGCCAAG TGTGGACAGA GGAGCCTCGA 
GCATTTAGCT CCTCTGTCAG AATGAATGGG AACCAGAAAT TGGATGCTTA TAACCAAGAA 
AAGCAGAATT TCATCCAGCA CTTCTCCCAG ATCGTCAAGG TGCTGACTGA GAAGGAGCTG 
GGACACCCAG AGATAGGGGA TGCTATTGCC CGGCTCAAGG AGGTCCTAGA GTACAATGCC 
TTAGGAGGCA AGTACAACCG GGGTTTGACC GTGGTACAAG CCTTCCAGGA GCTGGTGGAG 
CCGAAGAAAC AGGATGCTGA GAGTCTTCAG CGGGCCCTGA CAGTGGGCTG GTGTGTAGAA 
CTGCTCCAGG CTTTCTTCCT TGTGTCAGAT GACATCATGG ACTCTTCCCT CACTCGCCGG 
GGACAGATCT GCTGGTATCA GAAGCCAGGC ATAGGCTTGG ATGCCATCAA CGACGCTCTG 
CTTCTGGAAG CCTCCATCTA TCGTTTGCTG AAGTTCTACT GCAGGGAGCA GCCCTACTAC 
CTGAACCTGC TGGAGCTCTT TCTGCAGAGT TCCTATCAGA CAGAGATCGG GCAGACTCTA 
GACCTCATGA CAGCACCCCA GGGCCATGTG GATCTTGGTA GATACACTGA AAAGAGGTAC 
AAATCGATTG TCAAGTACAA GACGGCTTTC TACTCTTTCT ACCTGCCTAT TGCGGCCGCC 
ATGTACATGG CAGGCATTGA TGGGGAGAAG GAACACGCCA ATGCCCTGAA GATCCTGATG 
GAGATGGGCG AGTTCTTCCA GGTCCAGGAC GACTACCTTG ATCTCTTTGG AGACCCCAGT 
GTGACGGGAA AGGTCGGCAC TGACATCCAG GACAACAAAT GCAGCTGGCT GGTGGTTCAG 
TGTCTGCTAC GAGCCTCTCC TCAACAGCGC CAGATCTTAG AGGAGAATTA TGGGCAGAAG 
GACCCAGAAA AAGTGGCTCG GGTGAAAGCA CTGTATGAGG CGCTGGATCT GCAGTCTGCT 
TTCTTCAAGT ATGAGGAAGA CAGTTACAAC CGCCTCAAGA GTCTCATAGA GCAGTGCTCT 
GCGCCCCTGC CCCCATCCAT CTTCATGGAA CTTGCAAACA AGATCTACAA ACGGAGAAAG 
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001240680.1
CDS144..1406
Translation

Target ORF information:

RefSeq Version NM_001253751.1
Organism Mus musculus(house mouse)
Definition Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001253751.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGCCCCTGT CCTGCTGGCT GAGATCTCTG GGGGTCTTCC TGCTGCCAGC CCCCTGCTGG 
GCACCCCGGG AGAGGTGGCT TGGTTTCCTA CAACGACCCT CCCTGGCATA TGGGTGTCCA 
GTCCTGGGGG CCTGGCACAG TGCCCGCTGG TGGTGCCAAG TGTGGACAGA GGAGCCTCGA 
GCATTTAGCT CCTCTGTCAG AATGAATGGG AACCAGAAAT TGGATGCTTA TAACCAAGAA 
AAGCAGAATT TCATCCAGCA CTTCTCCCAG ATCGTCAAGG TGCTGACTGA GAAGGAGCTG 
GGACACCCAG AGATAGGGGA TGCTATTGCC CGGCTCAAGG AGGTCCTAGA GTACAATGCC 
TTAGGAGGCA AGTACAACCG GGGTTTGACC GTGGTACAAG CCTTCCAGGA GCTGGTGGAG 
CCGAAGAAAC AGGATGCTGA GAGTCTTCAG CGGGCCCTGA CAGTGGGCTG GTGTGTAGAA 
CTGCTCCAGG CTTTCTTCCT TGTGTCAGAT GACATCATGG ACTCTTCCCT CACTCGCCGG 
GGACAGATCT GCTGGTATCA GAAGCCAGGC ATAGGCTTGG ATGCCATCAA CGACGCTCTG 
CTTCTGGAAG CCTCCATCTA TCGTTTGCTG AAGTTCTACT GCAGGGAGCA GCCCTACTAC 
CTGAACCTGC TGGAGCTCTT TCTGCAGAGT TCCTATCAGA CAGAGATCGG GCAGACTCTA 
GACCTCATGA CAGCACCCCA GGGCCATGTG GATCTTGGTA GATACACTGA AAAGAGGTAC 
AAATCGATTG TCAAGTACAA GACGGCTTTC TACTCTTTCT ACCTGCCTAT TGCGGCCGCC 
ATGTACATGG CAGGCATTGA TGGGGAGAAG GAACACGCCA ATGCCCTGAA GATCCTGATG 
GAGATGGGCG AGTTCTTCCA GGTCCAGGAC GACTACCTTG ATCTCTTTGG AGACCCCAGT 
GTGACGGGAA AGGTCGGCAC TGACATCCAG GACAACAAAT GCAGCTGGCT GGTGGTTCAG 
TGTCTGCTAC GAGCCTCTCC TCAACAGCGC CAGATCTTAG AGGAGAATTA TGGGCAGAAG 
GACCCAGAAA AAGTGGCTCG GGTGAAAGCA CTGTATGAGG CGCTGGATCT GCAGTCTGCT 
TTCTTCAAGT ATGAGGAAGA CAGTTACAAC CGCCTCAAGA GTCTCATAGA GCAGTGCTCT 
GCGCCCCTGC CCCCATCCAT CTTCATGGAA CTTGCAAACA AGATCTACAA ACGGAGAAAG 
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu15781
Clone ID Related Accession (Same CDS sequence) NM_134469.4
Accession Version NM_134469.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1062bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-27
Organism Mus musculus(house mouse)
Product farnesyl pyrophosphate synthase isoform 2
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ082244.1, BC048497.1 and BE994006.1. On Dec 2, 2011 this sequence version replaced NM_134469.3. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087886.1, BC048497.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGAATGGGA ACCAGAAATT GGATGCTTAT AACCAAGAAA AGCAGAATTT CATCCAGCAC 
TTCTCCCAGA TCGTCAAGGT GCTGACTGAG AAGGAGCTGG GACACCCAGA GATAGGGGAT 
GCTATTGCCC GGCTCAAGGA GGTCCTAGAG TACAATGCCT TAGGAGGCAA GTACAACCGG 
GGTTTGACCG TGGTACAAGC CTTCCAGGAG CTGGTGGAGC CGAAGAAACA GGATGCTGAG 
AGTCTTCAGC GGGCCCTGAC AGTGGGCTGG TGTGTAGAAC TGCTCCAGGC TTTCTTCCTT 
GTGTCAGATG ACATCATGGA CTCTTCCCTC ACTCGCCGGG GACAGATCTG CTGGTATCAG 
AAGCCAGGCA TAGGCTTGGA TGCCATCAAC GACGCTCTGC TTCTGGAAGC CTCCATCTAT 
CGTTTGCTGA AGTTCTACTG CAGGGAGCAG CCCTACTACC TGAACCTGCT GGAGCTCTTT 
CTGCAGAGTT CCTATCAGAC AGAGATCGGG CAGACTCTAG ACCTCATGAC AGCACCCCAG 
GGCCATGTGG ATCTTGGTAG ATACACTGAA AAGAGGTACA AATCGATTGT CAAGTACAAG 
ACGGCTTTCT ACTCTTTCTA CCTGCCTATT GCGGCCGCCA TGTACATGGC AGGCATTGAT 
GGGGAGAAGG AACACGCCAA TGCCCTGAAG ATCCTGATGG AGATGGGCGA GTTCTTCCAG 
GTCCAGGACG ACTACCTTGA TCTCTTTGGA GACCCCAGTG TGACGGGAAA GGTCGGCACT 
GACATCCAGG ACAACAAATG CAGCTGGCTG GTGGTTCAGT GTCTGCTACG AGCCTCTCCT 
CAACAGCGCC AGATCTTAGA GGAGAATTAT GGGCAGAAGG ACCCAGAAAA AGTGGCTCGG 
GTGAAAGCAC TGTATGAGGC GCTGGATCTG CAGTCTGCTT TCTTCAAGTA TGAGGAAGAC 
AGTTACAACC GCCTCAAGAG TCTCATAGAG CAGTGCTCTG CGCCCCTGCC CCCATCCATC 
TTCATGGAAC TTGCAAACAA GATCTACAAA CGGAGAAAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_608219.1
CDS129..1190
Translation

Target ORF information:

RefSeq Version NM_134469.4
Organism Mus musculus(house mouse)
Definition Mus musculus farnesyl diphosphate synthetase (Fdps), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_134469.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGAATGGGA ACCAGAAATT GGATGCTTAT AACCAAGAAA AGCAGAATTT CATCCAGCAC 
TTCTCCCAGA TCGTCAAGGT GCTGACTGAG AAGGAGCTGG GACACCCAGA GATAGGGGAT 
GCTATTGCCC GGCTCAAGGA GGTCCTAGAG TACAATGCCT TAGGAGGCAA GTACAACCGG 
GGTTTGACCG TGGTACAAGC CTTCCAGGAG CTGGTGGAGC CGAAGAAACA GGATGCTGAG 
AGTCTTCAGC GGGCCCTGAC AGTGGGCTGG TGTGTAGAAC TGCTCCAGGC TTTCTTCCTT 
GTGTCAGATG ACATCATGGA CTCTTCCCTC ACTCGCCGGG GACAGATCTG CTGGTATCAG 
AAGCCAGGCA TAGGCTTGGA TGCCATCAAC GACGCTCTGC TTCTGGAAGC CTCCATCTAT 
CGTTTGCTGA AGTTCTACTG CAGGGAGCAG CCCTACTACC TGAACCTGCT GGAGCTCTTT 
CTGCAGAGTT CCTATCAGAC AGAGATCGGG CAGACTCTAG ACCTCATGAC AGCACCCCAG 
GGCCATGTGG ATCTTGGTAG ATACACTGAA AAGAGGTACA AATCGATTGT CAAGTACAAG 
ACGGCTTTCT ACTCTTTCTA CCTGCCTATT GCGGCCGCCA TGTACATGGC AGGCATTGAT 
GGGGAGAAGG AACACGCCAA TGCCCTGAAG ATCCTGATGG AGATGGGCGA GTTCTTCCAG 
GTCCAGGACG ACTACCTTGA TCTCTTTGGA GACCCCAGTG TGACGGGAAA GGTCGGCACT 
GACATCCAGG ACAACAAATG CAGCTGGCTG GTGGTTCAGT GTCTGCTACG AGCCTCTCCT 
CAACAGCGCC AGATCTTAGA GGAGAATTAT GGGCAGAAGG ACCCAGAAAA AGTGGCTCGG 
GTGAAAGCAC TGTATGAGGC GCTGGATCTG CAGTCTGCTT TCTTCAAGTA TGAGGAAGAC 
AGTTACAACC GCCTCAAGAG TCTCATAGAG CAGTGCTCTG CGCCCCTGCC CCCATCCATC 
TTCATGGAAC TTGCAAACAA GATCTACAAA CGGAGAAAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.
Biology of reproduction96(2)341-351(2017 02)
Lowther KM,Favero F,Yang CR,Taylor HS,Seli E


book

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
Journal of lipid research56(8)1551-9(2015 Aug)
?i?ecio?lu M,Budak H,Geffers L,?ankaya M,?iftci M,Thaller C,Eichele G,K?frevio?lu ??,?zdemir H


book

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
PloS one9(8)e105674(2014)
Patra D,DeLassus E,Liang G,Sandell LJ


book

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
Cardiovascular research97(3)490-9(2013 Mar)
Yang J,Mou Y,Wu T,Ye Y,Jiang JC,Zhao CZ,Zhu HH,Du CQ,Zhou L,Hu SJ