Gene Symbol | Bckdk |
Entrez Gene ID | 12041 |
Full Name | branched chain ketoacid dehydrogenase kinase |
Synonyms | AI327402 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Bckdk cDNA ORF clone
Gene Symbol | Bckdk |
Entrez Gene ID | 12041 |
Full Name | branched chain ketoacid dehydrogenase kinase |
Synonyms | AI327402 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_009739.3 | NP_033869.1 | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor |
BCKDK | XP_001112186.1 | |
Danio rerio (zebrafish) | bckdk | NP_998225.1 |
Saccharomyces cerevisiae (baker's yeast) | PKP1 | NP_012222.1 |
Homo sapiens (human) | BCKDK | NP_005872.2 |
Kluyveromyces lactis | KLLA0E04533g | XP_454150.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06200 | XP_003712087.1 |
Mus musculus (house mouse) | Bckdk | NP_033869.1 |
Rattus norvegicus (Norway rat) | Bckdk | NP_062117.2 |
Canis lupus familiaris (dog) | BCKDK | XP_536903.2 |
Bos taurus (cattle) | BCKDK | NP_001039371.1 |
Xenopus tropicalis (tropical clawed frog) | bckdk | XP_004919384.1 |
Pan troglodytes (chimpanzee) | BCKDK | XP_001156688.1 |
Eremothecium gossypii | AGOS_ADL116C | NP_983980.1 |
Neurospora crassa | NCU04349 | XP_956330.1 |
Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism.
Xu M, Kitaura Y, Ishikawa T, Kadota Y, Terai C, Shindo D, Morioka T, Ota M, Morishita Y, Ishihara K, Shimomura Y
PloS one12(7)e0180989(2017)
Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.
Ishikawa T, Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, Shimomura Y
Scientific reports739825(2017 Jan)
Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.
T?rlungeanu DC, Deliu E, Dotter CP, Kara M, Janiesch PC, Scalise M, Galluccio M, Tesulov M, Morelli E, Sonmez FM, Bilguvar K, Ohgaki R, Kanai Y, Johansen A, Esharif S, Ben-Omran T, Topcu M, Schlessinger A, Indiveri C, Duncan KE, Caglayan AO, Gunel M, Gleeson JG, Novarino G
Cell167(6)1481-1494.e18(2016 Dec)
A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent.
Cao H, Yu W, Li X, Wang J, Gao S, Holton NE, Eliason S, Sharp T, Amendt BA
Gene therapy23(6)527-42(2016 06)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results suggest that targeting mitochondrial BCKD kinase (BDK) as a pharmacological approach to mitigate the branched-chain amino acids (BCAAs) accumulation in metabolic diseases and heart failure.
Title: Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain ?-ketoacid dehydrogenase kinase.
leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 and BCKDK) that metabolize branched-chain amino acids.
Title: Oral leucine supplementation is sensed by the brain but neither reduces food intake nor induces an anorectic pattern of gene expression in the hypothalamus.
branched-chain a-keto acid dehydrogenase complex kinase plays an important role in conserving branched-chain amino acids by limiting their oxidation
Title: Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.
Tissue-specific translation of murine BCKDK mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region
Title: Tissue-specific translation of murine branched-chain alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region.
The following Bckdk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bckdk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13050 | |
Clone ID Related Accession (Same CDS sequence) | NM_009739.3 | |
Accession Version | NM_009739.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY077717.1 and AK150607.1. On Feb 25, 2006 this sequence version replaced NM_009739.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK150607.1, AK167519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta regulatory uORF :: PMID: 15302860 ##RefSeq-Attributes-END## |
1 | ATGATACTGA CTTCAGTGCT GGGCAGCGGC CCTCGGAGCT GGTCTTCACT TTGGCCCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033869.1 |
CDS | 266..1504 |
Translation |
Target ORF information:
Target ORF information:
|
NM_009739.3 |
1 | ATGATACTGA CTTCAGTGCT GGGCAGCGGC CCTCGGAGCT GGTCTTCACT TTGGCCCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism. |
Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition. |
Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder. |
A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent. |