Bhmt cDNA ORF clone, Mus musculus(house mouse)

Improved Sp1 and Betaine Homocysteine-S-Methyltransferase Expression and Homocysteine Clearance Are Involved in the Effects of Zinc on Oxidative Stress in High-Fat-Diet-Pretreated Mice.
Wu L, Zhou X, Li T, He J, Huang L, Ouyang Z, He L, Wei T, He Q
Biological trace element research(2017 Dec)

Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.
Prieur EAK, Pjetri E, Zeisel SH, Jadavji NM
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme42(11)1228-1231(2017 Nov)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo.
Jurkowska H, Niewiadomski J, Hirschberger LL, Roman HB, Mazor KM, Liu X, Locasale JW, Park E, Stipanuk MH
Amino acids48(3)665-76(2016 Mar)

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.
Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP
Cell reports12(3)371-9(2015 Jul)

BHMT expression is robustly regulated by taurine.
Title: Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo.

It was concluded that the BHMT pathway is a major route for the elimination of Hcy in mice and that the methionine synthase pathway has little excess capacity to methylate the Hcy that accumulates when the BHMT pathway is blocked.
Title: Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake.

mouse blastocysts are unusual in being able to generate AdoMet not only by the ubiquitous folate-dependent mechanism but also from betaine metabolized by BHMT
Title: Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development.

a role for BHMT in energy homeostasis.
Title: Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue.

BHMT has an important role in Hcy, choline, and one-carbon homeostasis
Title: Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.