Gene Symbol | Ccna2 |
Entrez Gene ID | 12428 |
Full Name | cyclin A2 |
Synonyms | AA408589,Ccn-1,Ccn1,Ccna,CycA2,Cyca |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ccna2 cDNA ORF clone
gRNAs
Gene Symbol | Ccna2 |
Entrez Gene ID | 12428 |
Full Name | cyclin A2 |
Synonyms | AA408589,Ccn-1,Ccn1,Ccna,CycA2,Cyca |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017319444.1 | XP_017174933.1 | cyclin-A2 isoform X1 |
NM_009828.2 | NP_033958.2 | cyclin-A2 |
NM_009828.3 | NP_033958.2 | cyclin-A2 |
Rattus norvegicus (Norway rat) | Ccna2 | NP_446154.3 |
Gallus gallus (chicken) | CCNA2 | NP_990575.1 |
Arabidopsis thaliana (thale cress) | CYCA2;3 | NP_173010.1 |
Homo sapiens (human) | CCNA2 | NP_001228.1 |
Pan troglodytes (chimpanzee) | CCNA2 | XP_517420.1 |
Oryza sativa (rice) | Os12g0502300 | NP_001066828.1 |
Xenopus tropicalis (tropical clawed frog) | ccna2 | NP_001006768.1 |
Mus musculus (house mouse) | Ccna2 | NP_033958.2 |
Danio rerio (zebrafish) | ccna2 | NP_694481.1 |
Arabidopsis thaliana (thale cress) | CYCA2;4 | NP_178153.1 |
CCNA2 | XP_001100860.1 | |
Canis lupus familiaris (dog) | CCNA2 | XP_540965.2 |
Bos taurus (cattle) | CCNA2 | NP_001068591.1 |
Drosophila melanogaster (fruit fly) | CycA | NP_001246724.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012413 | XP_320142.3 |
Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins.
Choiniere J, Wu J, Wang L
Molecular pharmacology91(3)189-196(2017 Mar)
Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
Hirai M, Arita Y, McGlade CJ, Lee KF, Chen J, Evans SM
The Journal of clinical investigation127(2)569-582(2017 Feb)
Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.
Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM
Science (New York, N.Y.)353(6307)1549-1552(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
Title: Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.
Meioc-deficient spermatocytes that have initiated synapsis mis-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
Title: Meioc maintains an extended meiotic prophase I in mice.
inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins.
Title: Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Title: Cyclin A2 regulates erythrocyte morphology and numbers.
cyclin A2 controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation.
Title: Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.
The following Ccna2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccna2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu20167 | |
Clone ID Related Accession (Same CDS sequence) | XM_017319444.1 , NM_009828.2 , NM_009828.3 | |
Accession Version | NM_009828.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1269bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-05-06 | |
Organism | Mus musculus(House mouse) | |
Product | cyclin-A2 | |
Comment | VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB642910.1, BC052730.1, AK044924.1 and Z26580.1. On Nov 30, 2007 this sequence version replaced NM_009828.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z26580.1, AK044924.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGGGCA CCTCGAGGCA TTCGGGTCGC GATGCGGGCT CAGCCCTGCT CTCGCTGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033958.2 |
CDS | 174..1442 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCCGGGCA CCTCGAGGCA TTCGGGTCGC GATGCGGGCT CAGCCCTGCT CTCGCTGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20167 | |
Clone ID Related Accession (Same CDS sequence) | XM_017319444.1 , NM_009828.2 , NM_009828.3 | |
Accession Version | NM_009828.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1269bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-14 | |
Organism | Mus musculus(house mouse) | |
Product | cyclin-A2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC117584.11, BC052730.1 and AK044924.1. On or before Sep 20, 2017 this sequence version replaced XM_017319444.1, NM_009828.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.267436.1, SRR1660813.153836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGGGCA CCTCGAGGCA TTCGGGTCGC GATGCGGGCT CAGCCCTGCT CTCGCTGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033958.2 |
CDS | 739..2007 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCGGGCA CCTCGAGGCA TTCGGGTCGC GATGCGGGCT CAGCCCTGCT CTCGCTGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20167 | |
Clone ID Related Accession (Same CDS sequence) | XM_017319444.1 , NM_009828.2 , NM_009828.3 | |
Accession Version | XM_017319444.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1269bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | cyclin-A2 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCGGGCA CCTCGAGGCA TTCGGGTCGC GATGCGGGCT CAGCCCTGCT CTCGCTGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017174933.1 |
CDS | 726..1994 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCGGGCA CCTCGAGGCA TTCGGGTCGC GATGCGGGCT CAGCCCTGCT CTCGCTGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. |
Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. |
Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. |