Gene Symbol | Ccs |
Entrez Gene ID | 12460 |
Full Name | copper chaperone for superoxide dismutase |
Synonyms | Ccsd |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ccs cDNA ORF clone
Gene Symbol | Ccs |
Entrez Gene ID | 12460 |
Full Name | copper chaperone for superoxide dismutase |
Synonyms | Ccsd |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_016892.3 | NP_058588.1 | copper chaperone for superoxide dismutase |
XM_006531645.2 | XP_006531708.1 | copper chaperone for superoxide dismutase isoform X1 |
Rattus norvegicus (Norway rat) | Ccs | NP_445877.1 |
Danio rerio (zebrafish) | ccs | NP_001191151.1 |
CCS | XP_001118002.2 | |
Canis lupus familiaris (dog) | CCS | NP_001181899.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP007026 | XP_308747.4 |
Homo sapiens (human) | CCS | NP_005116.1 |
Rattus norvegicus (Norway rat) | LOC100911589 | XP_003749080.1 |
Drosophila melanogaster (fruit fly) | CCS | NP_001163108.1 |
Saccharomyces cerevisiae (baker's yeast) | CCS1 | NP_013752.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_05281 | XP_003712840.1 |
Arabidopsis thaliana (thale cress) | CCS | NP_563910.2 |
Oryza sativa (rice) | Os04g0573200 | NP_001053613.1 |
Mus musculus (house mouse) | Ccs | NP_058588.1 |
Neurospora crassa | NCU07851 | XP_963112.2 |
Xenopus tropicalis (tropical clawed frog) | ccs | NP_001011020.1 |
Pan troglodytes (chimpanzee) | CCS | NP_001167001.1 |
Kluyveromyces lactis | KLLA0F26917g | XP_456277.1 |
The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.
Baker ZN, Jett K, Boulet A, Hossain A, Cobine PA, Kim BE, El Zawily AM, Lee L, Tibbits GF, Petris MJ, Leary SC
Human molecular genetics26(23)4617-4628(2017 Dec)
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)
Effects of Cu,Zn-superoxide dismutase on cell proliferation and neuroblast differentiation in the mouse dentate gyrus.
Yoo DY, Shin BN, Kim IH, Kim W, Kim DW, Yoo KY, Choi JH, Lee CH, Yoon YS, Choi SY, Won MH, Hwang IK
Neurochemical research37(2)261-7(2012 Feb)
Erythrocyte copper chaperone for superoxide dismutase is increased following marginal copper deficiency in adult and postweanling mice.
Lassi KC, Prohaska JR
The Journal of nutrition142(2)292-7(2012 Feb)
Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis.
Miyayama T, Ishizuka Y, Iijima T, Hiraoka D, Ogra Y
Metallomics : integrated biometal science3(7)693-701(2011 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
results suggest that a SOD1 supplement to healthy mice may not be necessary to modulate cell proliferation and neuroblast differentiation in the dentate gyrus
Title: Effects of Cu,Zn-superoxide dismutase on cell proliferation and neuroblast differentiation in the mouse dentate gyrus.
Small interfering RNA (siRNA) targeting CCS was introduced into metallothionein-knockout mouse fibroblasts (MT-KO cells) and their wild type cells (MT-WT cells) to reveal the interactive role of CCS with other Cu-regulating proteins.
Title: Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis.
effects of copper chaperone for SOD1 on mitochondrial dysfunction are SOD1 mutation dependent and correlate with SOD1 redox susceptibility
Title: Redox susceptibility of SOD1 mutants is associated with the differential response to CCS over-expression in vivo.
Study finds that as expected, CCS over-expression promotes oxidation of a wild-type SOD1 disulfide; however, in the diseased G93A/CCS mouse, there was no increased oxidation of the mutant SOD1 disulfide.
Title: Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS.
These results establish that CCS/G93A SOD1 mice manifest an isolated complex IV deficiency which may underlie a substantial part of mutant SOD1-induced mitochondrial cytopathy.
Title: Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein.
The following Ccs gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccs cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu55008 | |
Clone ID Related Accession (Same CDS sequence) | XM_006531645.2 | |
Accession Version | XM_006531645.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | copper chaperone for superoxide dismutase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006531645.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTTCGA AGTCGGGGGA CGGTGGGACT GTGTGTGCGT TGGAGTTTGC AGTGCAGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006531708.1 |
CDS | 93..581 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006531645.2 |
1 | ATGGCTTCGA AGTCGGGGGA CGGTGGGACT GTGTGTGCGT TGGAGTTTGC AGTGCAGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu10525 | |
Clone ID Related Accession (Same CDS sequence) | NM_016892.3 | |
Accession Version | NM_016892.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Mus musculus(house mouse) | |
Product | copper chaperone for superoxide dismutase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY073478.1, AK050072.1 and CF929049.1. On Sep 14, 2006 this sequence version replaced NM_016892.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF173379.1, BC026938.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTTCGA AGTCGGGGGA CGGTGGGACT GTGTGTGCGT TGGAGTTTGC AGTGCAGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_058588.1 |
CDS | 88..912 |
Translation |
Target ORF information:
Target ORF information:
|
NM_016892.3 |
1 | ATGGCTTCGA AGTCGGGGGA CGGTGGGACT GTGTGTGCGT TGGAGTTTGC AGTGCAGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
Effects of Cu,Zn-superoxide dismutase on cell proliferation and neuroblast differentiation in the mouse dentate gyrus. |
Erythrocyte copper chaperone for superoxide dismutase is increased following marginal copper deficiency in adult and postweanling mice. |
Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis. |