Cstb cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Cstb |
| Entrez Gene ID | 13014 |
| Full Name | cystatin B |
| Synonyms | AA960480,Stfb |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_007793.3 | NP_031819.1 | cystatin-B |
| Mus musculus (house mouse) | Cstb | NP_031819.1 |
| Gallus gallus (chicken) | CSTB | NP_001185577.1 |
| Danio rerio (zebrafish) | zgc:56530 | NP_001096599.1 |
| CSTB | XP_001104524.1 | |
| Bos taurus (cattle) | CSTB | NP_001032538.1 |
| Danio rerio (zebrafish) | zgc:153129 | NP_001070742.1 |
| Danio rerio (zebrafish) | si:ch211-161h7.6 | XP_698401.1 |
| Rattus norvegicus (Norway rat) | Cstb | NP_036970.1 |
| Homo sapiens (human) | CSTB | NP_000091.1 |
| Pan troglodytes (chimpanzee) | CSTB | NP_001009095.1 |
Related articles in PubMed
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)
Brain inflammation is accompanied by peripheral inflammation in Cstb
Okuneva O, Li Z, K?rber I, Tegelberg S, Joensuu T, Tian L, Lehesjoki AE
Journal of neuroinflammation13(1)298(2016 Nov)
Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration.
Chung C, Puthanveetil P, Ory DS, Lieberman AP
Human molecular genetics25(7)1434-46(2016 Apr)
Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.
K?rber I, Katayama S, Einarsdottir E, Krjut?kov K, Hakala P, Kere J, Lehesjoki AE, Joensuu T
PloS one11(6)e0158195(2016)
Abnormal microglial activation in the Cstb(-/-) mouse, a model for progressive myoclonus epilepsy, EPM1.
Okuneva O, K?rber I, Li Z, Tian L, Joensuu T, Kopra O, Lehesjoki AE
Glia63(3)400-11(2015 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The data of this study show that CXCL13 expression is a hallmark of microglial activation in Cstb (-/-) mice and that the brain inflammation is linked to peripheral inflammatory changes, which might contribute to the disease pathology of progressive myoclonus epilepsy..
Title: Brain inflammation is accompanied by peripheral inflammation in Cstb
Deletion of the encoding Cstb gene in Npc1-deficient mice resulted in striking deleterious effects, particularly within the cerebellum where diffuse loss of Purkinje cells was observed in young mice. This may be a consequence of damage to lysosomal membranes by reactive oxygen species (ROS), leading to the leakage of lysosomal contents that culminates in apoptosis.
Title: Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration.
CSTB has a role in chemotaxis, antigen-presentation, and in immune- and defense response-associated processes by altering JAK-STAT pathway signaling
Title: Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.
Results suggest a role for CSTB in regulating microglial activation: data link CSTB deficiency to early activation and altered functional properties of microglia, imply presence of both enhanced and suppressed immune response-related microglial functions
Title: Abnormal microglial activation in the Cstb(-/-) mouse, a model for progressive myoclonus epilepsy, EPM1.
the LPS-induced sepsis in StB KO mice is dependent on caspase-11 and mitochondrial reactive oxygen species but is not associated with the lysosomal destabilization and increased cathepsin activity in the cytosol
Title: A role for stefin B (cystatin B) in inflammation and endotoxemia.
The following Cstb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cstb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu17903 | |
| Clone ID Related Accession (Same CDS sequence) | NM_007793.3 | |
| Accession Version | NM_007793.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Mus musculus(house mouse) | |
| Product | cystatin-B | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY091749.1 and BC056170.1. On Dec 23, 2005 this sequence version replaced NM_007793.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056170.1, CK792726.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGATGTGTG GCGCGCCATC TGCCACAATG CCAGCCACGG CCGAGACGCA GGAGGTCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_031819.1 |
| CDS | 123..419 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_007793.3 |
ORF Insert Sequence:
1 | ATGATGTGTG GCGCGCCATC TGCCACAATG CCAGCCACGG CCGAGACGCA GGAGGTCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. |
|
Brain inflammation is accompanied by peripheral inflammation in Cstb |
|
Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration. |
|
Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia. |
|
Abnormal microglial activation in the Cstb(-/-) mouse, a model for progressive myoclonus epilepsy, EPM1. |