Gene Symbol | Mtpn |
Entrez Gene ID | 14489 |
Full Name | myotrophin |
Synonyms | 5033418D15Rik,Gcdp,V1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Mtpn cDNA ORF clone
Gene Symbol | Mtpn |
Entrez Gene ID | 14489 |
Full Name | myotrophin |
Synonyms | 5033418D15Rik,Gcdp,V1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008098.4 | NP_032124.1 | myotrophin |
Danio rerio (zebrafish) | mtpn | NP_998137.1 |
Drosophila melanogaster (fruit fly) | CG7423 | NP_573347.1 |
Caenorhabditis elegans (roundworm) | C43H6.3 | NP_508437.1 |
Xenopus tropicalis (tropical clawed frog) | mtpn | NP_989406.1 |
Pan troglodytes (chimpanzee) | MTPN | XP_519405.2 |
Bos taurus (cattle) | MTPN | NP_976238.2 |
Mus musculus (house mouse) | Mtpn | NP_032124.1 |
Gallus gallus (chicken) | MTPN | NP_990217.1 |
Drosophila melanogaster (fruit fly) | CG31715 | NP_723568.1 |
Homo sapiens (human) | MTPN | NP_665807.1 |
MTPN | XP_001106700.1 | |
Canis lupus familiaris (dog) | MTPN | NP_001002989.1 |
Rattus norvegicus (Norway rat) | Mtpn | NP_077350.1 |
Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.
Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK
Differentiation; research in biological diversity948-20(2017 Mar - Apr)
Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges.
Fujiwara I, Remmert K, Piszczek G, Hammer JA
Proceedings of the National Academy of Sciences of the United States of America111(19)E1970-9(2014 May)
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Campbell GR, Baudhuin A, Vranizan K, Ngai J
Molecular and cellular neurosciences46(2)548-61(2011 Feb)
miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression.
Li Y, Xu X, Liang Y, Liu S, Xiao H, Li F, Cheng H, Fu Z
International journal of clinical and experimental pathology3(3)254-64(2010 Jan)
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our data argue that a large pool of freely diffusing, inactive capping protein (CP:V-1) feeds, via CARMIL-driven complex exchange, the formation of weak-capping complexes (CP:CARMIL) at the plasma membrane of protruding edges.
Title: Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges.
miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells (a NOD-derived beta-cell line) by repressing myotrophin (V1) protein expression.
Title: miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression.
actin-capping protein binds to the filament barbed end of myotrophin/V-1
Title: Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end.
myotrophin has a role in myocardial hypertrophy and heart failure
Title: Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice.
Rat neonatal cardiac myocytes incubated with myotrophin showed an increase in c-myc, c-fos, and c-jun RNA levels and an increase in connexin 43, atrial natriuretic factor, skeletal alpha-actin, and total myosin transcript levels.
Title: Myotrophin induces early response genes and enhances cardiac gene expression.
The following Mtpn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mtpn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu15931 | |
Clone ID Related Accession (Same CDS sequence) | NM_008098.4 | |
Accession Version | NM_008098.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | myotrophin | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA559569.1, BC054811.1, AK049398.1 and AC166251.6. On May 7, 2009 this sequence version replaced NM_008098.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.73677.1, AK049398.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTGCGACA AGGAGTTCAT GTGGGCCCTG AAAAACGGAG ACTTGGATGA GGTGAAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032124.1 |
CDS | 279..635 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008098.4 |
1 | ATGTGCGACA AGGAGTTCAT GTGGGCCCTG AAAAACGGAG ACTTGGATGA GGTGAAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. |
Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edges. |
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. |
miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression. |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |