Gene Symbol | Gch1 |
Entrez Gene ID | 14528 |
Full Name | GTP cyclohydrolase 1 |
Synonyms | GTP-CH,GTPCH,Gch |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Gch1 cDNA ORF clone
Gene Symbol | Gch1 |
Entrez Gene ID | 14528 |
Full Name | GTP cyclohydrolase 1 |
Synonyms | GTP-CH,GTPCH,Gch |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008102.3 | NP_032128.1 | GTP cyclohydrolase 1 precursor |
NM_008102.4 | NP_032128.1 | GTP cyclohydrolase 1 |
Pan troglodytes (chimpanzee) | GCH1 | XP_001161622.1 |
Mus musculus (house mouse) | Gch1 | NP_032128.1 |
Danio rerio (zebrafish) | gch1 | NP_001129727.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006441 | XP_316477.4 |
Saccharomyces cerevisiae (baker's yeast) | FOL2 | NP_011783.1 |
Kluyveromyces lactis | KLLA0A09735g | XP_451425.1 |
Homo sapiens (human) | GCH1 | NP_000152.1 |
Gallus gallus (chicken) | GCH1 | NP_990554.1 |
Schizosaccharomyces pombe (fission yeast) | SPAC17A5.13 | NP_593481.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_09458 | XP_003712296.1 |
Rattus norvegicus (Norway rat) | Gch1 | NP_077332.1 |
Drosophila melanogaster (fruit fly) | Pu | NP_726038.1 |
Canis lupus familiaris (dog) | GCH1 | XP_005623474.1 |
Bos taurus (cattle) | GCH1 | XP_002690995.1 |
Xenopus tropicalis (tropical clawed frog) | gch1 | NP_001006789.1 |
GCH1 | XP_001087365.1 | |
Caenorhabditis elegans (roundworm) | cat-4 | NP_505710.1 |
Eremothecium gossypii | AGOS_AGR335C | NP_987001.1 |
Neurospora crassa | NCU07774 | XP_958695.2 |
Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy.
Wu HE, Baumgardt SL, Fang J, Paterson M, Liu Y, Du J, Shi Y, Qiao S, Bosnjak ZJ, Warltier DC, Kersten JR, Ge ZD
Scientific reports627925(2016 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart.
Title: Increasing tetrahydrobiopterin in cardiomyocytes adversely affects cardiac redox state and mitochondrial function independently of changes in NO production.
Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.
Title: A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
gene expression analysis after iNOS induction identified 78 genes that were altered between wild-type and Gch1(fl/fl)Tie2cre macrophages
Title: Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Title: Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.
Title: GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1.
The following Gch1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gch1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu01360 | |
Clone ID Related Accession (Same CDS sequence) | NM_008102.3 , NM_008102.4 | |
Accession Version | NM_008102.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-05-27 | |
Organism | Mus musculus(house mouse) | |
Product | GTP cyclohydrolase 1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC154589.3 and AC159006.2. On Nov 17, 2006 this sequence version replaced NM_008102.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005643.1, AK150657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGAAGC CGCGGGGAGT CAGGTGCACC AATGGGTTCT CCGAGCGGGA GCTGCCGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032128.1 |
CDS | 136..861 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008102.3 |
1 | ATGGAGAAGC CGCGGGGAGT CAGGTGCACC AATGGGTTCT CCGAGCGGGA GCTGCCGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu01360 | |
Clone ID Related Accession (Same CDS sequence) | NM_008102.3 , NM_008102.4 | |
Accession Version | NM_008102.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-29 | |
Organism | Mus musculus(house mouse) | |
Product | GTP cyclohydrolase 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154589.3 and AC159006.2. On Apr 14, 2018 this sequence version replaced NM_008102.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK150657.1, AK152571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGAAGC CGCGGGGAGT CAGGTGCACC AATGGGTTCT CCGAGCGGGA GCTGCCGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032128.1 |
CDS | 147..872 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008102.4 |
1 | ATGGAGAAGC CGCGGGGAGT CAGGTGCACC AATGGGTTCT CCGAGCGGGA GCTGCCGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy. |