Rack1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Rack1
Entrez Gene ID	14694
Full Name	receptor for activated C kinase 1
Synonyms	AL033335,GB-like,Gnb2-rs1,Gnb2l1,p205
General protein information	Preferred Names receptor for activated C kinase 1 Names receptor of activated protein C kinase 1 12-3 activated protein kinase C receptor guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 guanine nucleotide binding protein related guanine nucleotide binding protein, beta 2, related sequence 1 guanine nucleotide-binding protein subunit beta-2-like 1 receptor of activated protein kinase C 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B1.2

mRNA and Protein(s)

mRNA Protein Name

NM_008143.3 NP_032169.1 receptor of activated protein C kinase 1
Pathways from BioSystems

mRNA	Protein	Name
NM_008143.3	NP_032169.1	receptor of activated protein C kinase 1

Homologies

Homo sapiens (human)	GNB2L1	NP_006089.1
Pan troglodytes (chimpanzee)	GNB2L1	XP_518165.3
	LOC708526	XP_001105066.1
Caenorhabditis elegans (roundworm)	rack-1	NP_501859.1
Kluyveromyces lactis	KLLA0E12277g	XP_454502.1
Schizosaccharomyces pombe (fission yeast)	cpc2	NP_593770.1
Arabidopsis thaliana (thale cress)	ATARCA	NP_173248.1
Bos taurus (cattle)	GNB2L1	XP_005209294.1
Mus musculus (house mouse)	Gnb2l1	NP_032169.1
Rattus norvegicus (Norway rat)	Gnb2l1	NP_570090.2
Magnaporthe oryzae (rice blast fungus)	MGG_04719	XP_003710816.1
Arabidopsis thaliana (thale cress)	RACK1B_AT	NP_175296.1
Gallus gallus (chicken)	GNB2L1	NP_001004378.1
Drosophila melanogaster (fruit fly)	Rack1	NP_001260218.1
Saccharomyces cerevisiae (baker's yeast)	ASC1	NP_013834.1
Eremothecium gossypii	AGOS_AFR199C	NP_985746.1
Arabidopsis thaliana (thale cress)	RACK1C_AT	NP_188441.1
Oryza sativa (rice)	Os01g0686800	NP_001043910.1
Oryza sativa (rice)	Os05g0552300	NP_001056254.1
Canis lupus familiaris (dog)	GNB2L1	XP_005626337.1
Danio rerio (zebrafish)	gnb2l1	NP_571519.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010173	XP_319347.2
Neurospora crassa	NCU05810	XP_960070.1
Xenopus tropicalis (tropical clawed frog)	gnb2l1	NP_001004946.1

Gene Ontology
Bibliography

Related articles in PubMed

Rack1 function in intestinal epithelia: regulating crypt cell proliferation and regeneration and promoting differentiation and apoptosis.
Cheng ZF, Pai RK, Cartwright CA
American journal of physiology. Gastrointestinal and liver physiology314(1)G1-G13(2018 Jan)

Rack1 maintains intestinal homeostasis by protecting the integrity of the epithelial barrier.
Cheng ZF, Cartwright CA
American journal of physiology. Gastrointestinal and liver physiologyajpgi002412017(2017 Oct)

RACK1 is necessary for the formation of point contacts and regulates axon growth.
Kershner L, Welshhans K
Developmental neurobiology77(9)1038-1056(2017 Sep)

RACK1 cooperates with NRAS
Campagne C, Reyes-Gomez E, Picco ME, Loiodice S, Salaun P, Ezagal J, Bernex F, Comm?re PH, Pons S, Esquerre D, Bourneuf E, Estell? J, Maskos U, Lopez-Bergami P, Aubin-Houzelstein G, Panthier JJ, Egidy G
Cellular signalling36255-266(2017 Aug)

Over-expression of insulin-response element binding protein-1 (IRE-BP1) in mouse pancreatic islets increases expression of RACK1 and TCTP: Beta cell markers of high glucose sensitivity.
Villafuerte BC, Barati MT, Rane MJ, Isaacs S, Li M, Wilkey DW, Merchant ML
Biochimica et biophysica acta1865(2)186-194(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Leads to the enhanced and previously un-described interaction of RACK1 and TCTP.
Title: Over-expression of insulin-response element binding protein-1 (IRE-BP1) in mouse pancreatic islets increases expression of RACK1 and TCTP: Beta cell markers of high glucose sensitivity.

urther investigation indicated that p205 may disturb the formation of Runx2/Ids complex and free more Runx2 to induce the differentiation process. Taken together, our findings demonstrated for the first time that p205 functions as an activator in osteoblast differentiation.
Title: The interferon-inducible protein p205 acts as an activator in osteoblast differentiation of mouse BMSCs.

RACK1 is a novel factor required for adipocyte differentiation.
Title: RACK1 is required for adipogenesis.

RACK1 competes with Rab40C for binding to the ANKR2 domain of Varp and regulates dendrite outgrowth through stabilization of Varp in mouse melanocytes
Title: A Varp-Binding Protein, RACK1, Regulates Dendrite Outgrowth through Stabilization of Varp Protein in Mouse Melanocytes.

Data show that receptor for activated C-kinase 1 (RACK1) and vascular endothelial growth factor (VEGF) expression is up-regulated after choroidal neovascularization (CNV) formation.
Title: Inhibition of RACK1 ameliorates choroidal neovascularization formation in vitro and in vivo.

The following Rack1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rack1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19499	NM_008143.3 Latest version!	Mus musculus receptor for activated C kinase 1 (Rack1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rack1 ( NM_008143.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032169.1 Mus musculus receptor for activated C kinase 1 (Rack1), mRNA.

Price & Availability↑

CloneID	OMu19499
Clone ID Related Accession (Same CDS sequence)	NM_008143.3
Accession Version	NM_008143.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	receptor of activated protein C kinase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK017772.1. On Apr 6, 2007 this sequence version replaced NM_008143.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK017772.1, AK159797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGAGC AGATGACCCT TCGCGGGACC CTTAAGGGCC ACAATGGATG GGTAACACAG 
ATCGCCACCA CACCGCAGTT CCCGGACATG ATCCTGTCTG CGTCTCGAGA CAAGACCATC 
ATCATGTGGA AGCTGACCAG AGATGAGACC AACTATGGCA TACCACAGCG TGCTCTGAGA 
GGTCACTCCC ACTTCGTTAG TGATGTTGTT ATCTCCTCTG ATGGTCAGTT TGCCCTCTCG 
GGCTCCTGGG ACGGAACGCT GCGCCTCTGG GATCTCACAA CGGGCACCAC CACAAGGCGA 
TTTGTCGGCC ACACCAAGGA TGTGTTGAGC GTGGCCTTCT CCTCTGACAA CCGGCAGATT 
GTCTCTGGGT CCCGAGACAA GACCATAAAG TTATGGAATA CTCTGGGTGT CTGCAAGTAC 
ACGGTCCAGG ATGAGAGTCA TTCAGAATGG GTGTCTTGTG TCCGCTTCTC CCCGAACAGC 
AGCAACCCTA TCATCGTCTC CTGCGGATGG GACAAGCTGG TCAAGGTGTG GAATCTGGCT 
AACTGCAAGC TAAAGACCAA CCACATTGGC CACACTGGCT ACCTGAACAC AGTGACTGTC 
TCTCCAGATG GATCCCTCTG TGCTTCTGGA GGCAAGGATG GCCAGGCTAT GCTGTGGGAT 
CTCAATGAAG GCAAGCACCT CTACACTTTA GATGGTGGGG ACATCATCAA TGCCTTGTGC 
TTCAGCCCCA ACCGCTACTG GCTCTGCGCT GCCACTGGCC CCAGCATCAA GATCTGGGAC 
TTGGAGGGCA AGATCATTGT AGATGAATTG AAGCAAGAAG TTATCAGCAC CAGCAGCAAG 
GCAGAGCCAC CCCAGTGTAC CTCTTTGGCA TGGTCTGCTG ATGGCCAGAC TCTGTTTGCT 
GGCTATACAG ACAACTTGGT GCGAGTATGG CAGGTAACTA TTGGTACCCG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032169.1
CDS	105..1058
Translation	MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR

Target ORF information:

RefSeq Version	NM_008143.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus receptor for activated C kinase 1 (Rack1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008143.3

ORF Insert Sequence:

ATGACCGAGC AGATGACCCT TCGCGGGACC CTTAAGGGCC ACAATGGATG GGTAACACAG 
ATCGCCACCA CACCGCAGTT CCCGGACATG ATCCTGTCTG CGTCTCGAGA CAAGACCATC 
ATCATGTGGA AGCTGACCAG AGATGAGACC AACTATGGCA TACCACAGCG TGCTCTGAGA 
GGTCACTCCC ACTTCGTTAG TGATGTTGTT ATCTCCTCTG ATGGTCAGTT TGCCCTCTCG 
GGCTCCTGGG ACGGAACGCT GCGCCTCTGG GATCTCACAA CGGGCACCAC CACAAGGCGA 
TTTGTCGGCC ACACCAAGGA TGTGTTGAGC GTGGCCTTCT CCTCTGACAA CCGGCAGATT 
GTCTCTGGGT CCCGAGACAA GACCATAAAG TTATGGAATA CTCTGGGTGT CTGCAAGTAC 
ACGGTCCAGG ATGAGAGTCA TTCAGAATGG GTGTCTTGTG TCCGCTTCTC CCCGAACAGC 
AGCAACCCTA TCATCGTCTC CTGCGGATGG GACAAGCTGG TCAAGGTGTG GAATCTGGCT 
AACTGCAAGC TAAAGACCAA CCACATTGGC CACACTGGCT ACCTGAACAC AGTGACTGTC 
TCTCCAGATG GATCCCTCTG TGCTTCTGGA GGCAAGGATG GCCAGGCTAT GCTGTGGGAT 
CTCAATGAAG GCAAGCACCT CTACACTTTA GATGGTGGGG ACATCATCAA TGCCTTGTGC 
TTCAGCCCCA ACCGCTACTG GCTCTGCGCT GCCACTGGCC CCAGCATCAA GATCTGGGAC 
TTGGAGGGCA AGATCATTGT AGATGAATTG AAGCAAGAAG TTATCAGCAC CAGCAGCAAG 
GCAGAGCCAC CCCAGTGTAC CTCTTTGGCA TGGTCTGCTG ATGGCCAGAC TCTGTTTGCT 
GGCTATACAG ACAACTTGGT GCGAGTATGG CAGGTAACTA TTGGTACCCG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rack1 function in intestinal epithelia: regulating crypt cell proliferation and regeneration and promoting differentiation and apoptosis.
American journal of physiology. Gastrointestinal and liver physiology314(1)G1-G13(2018 Jan)
Cheng ZF,Pai RK,Cartwright CA

Rack1 maintains intestinal homeostasis by protecting the integrity of the epithelial barrier.
American journal of physiology. Gastrointestinal and liver physiologyajpgi002412017(2017 Oct)
Cheng ZF,Cartwright CA

RACK1 is necessary for the formation of point contacts and regulates axon growth.
Developmental neurobiology77(9)1038-1056(2017 Sep)
Kershner L,Welshhans K

RACK1 cooperates with NRAS
Cellular signalling36255-266(2017 Aug)
Campagne C,Reyes-Gomez E,Picco ME,Loiodice S,Salaun P,Ezagal J,Bernex F,Comm?re PH,Pons S,Esquerre D,Bourneuf E,Estell? J,Maskos U,Lopez-Bergami P,Aubin-Houzelstein G,Panthier JJ,Egidy G

Over-expression of insulin-response element binding protein-1 (IRE-BP1) in mouse pancreatic islets increases expression of RACK1 and TCTP: Beta cell markers of high glucose sensitivity.
Biochimica et biophysica acta1865(2)186-194(2017 02)
Villafuerte BC,Barati MT,Rane MJ,Isaacs S,Li M,Wilkey DW,Merchant ML

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Rack1 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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