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Hsd17b3 cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Hsd17b3
Entrez Gene ID 15487
Full Name hydroxysteroid (17-beta) dehydrogenase 3
General protein information
Preferred Names

hydroxysteroid (17-beta) dehydrogenase 3

Names

testosterone 17-beta-dehydrogenase 3
17(beta)HSD type 3
17-beta-HSD 3
17-beta-hydroxysteroid dehydrogenase type 3
testicular 17-beta-hydroxysteroid dehydrogenase
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

13

13|13 B3

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_008291.3 NP_032317.2 testosterone 17-beta-dehydrogenase 3
XM_006517108.3 XP_006517171.1 testosterone 17-beta-dehydrogenase 3 isoform X1

Pathways from BioSystems


Homologies


HSD17B3 XP_001105829.1
Bos taurus (cattle) HSD17B3 NP_001069907.1
Gallus gallus (chicken) ZNF367 XP_425046.4
Danio rerio (zebrafish) hsd17b3 NP_956658.1
Pan troglodytes (chimpanzee) HSD17B3 XP_001151508.1
Canis lupus familiaris (dog) HSD17B3 XP_003638918.1
Homo sapiens (human) HSD17B3 NP_000188.1
Mus musculus (house mouse) Hsd17b3 NP_032317.2
Xenopus tropicalis (tropical clawed frog) hsd17b3 XP_004911462.1
Rattus norvegicus (Norway rat) Hsd17b3 NP_446459.1

Gene Ontology


Bibliography

Related articles in PubMed

Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice.
Umehara T, Kawashima I, Kawai T, Hoshino Y, Morohashi KI, Shima Y, Zeng W, Richards JS, Shimada M
Endocrinology157(12)4899-4913(2016 Dec)

Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.
Inoue M, Shima Y, Miyabayashi K, Tokunaga K, Sato T, Baba T, Ohkawa Y, Akiyama H, Suyama M, Morohashi K
Endocrinology157(3)1222-33(2016 Mar)

Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation.
Zhang L, Chen M, Wen Q, Li Y, Wang Y, Wang Y, Qin Y, Cui X, Yang L, Huff V, Gao F
Proceedings of the National Academy of Sciences of the United States of America112(13)4003-8(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High 4-tert-Octylphenol doses affect the cytoarchitecture of MA-10 Leydig cells as well as attenuate 3beta-HSD and AR expression.
Title: Octylphenol affects morphology and steroidogenesis in mouse tumor Leydig cells.

Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc, P450(17alpha) and 17beta-HSD in mice.
Title: Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice.

Enzyme activities of 3-betaHSDH increase as the sound pressure levels increase in adrenal cortex zona fasciculate polygonal cells.
Title: [Effects of infrasound on activities of 3beta hydroxysteroid dehydrogenase and acid phosphatase of polygonal cells in adrenal cortex zona fasciculate in mice].

The following Hsd17b3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsd17b3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu01669 NM_008291.3
Latest version!		 Mus musculus hydroxysteroid (17-beta) dehydrogenase 3 (Hsd17b3), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $188.30
$269.00
OMu48674 XM_006517108.3
Latest version!		 Mus musculus hydroxysteroid (17-beta) dehydrogenase 3 (Hsd17b3), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu01669
Clone ID Related Accession (Same CDS sequence) NM_008291.3
Accession Version NM_008291.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 918bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-14
Organism Mus musculus(house mouse)
Product testosterone 17-beta-dehydrogenase 3
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB621153.1, U66827.1 and BB041573.2. On Jul 25, 2007 this sequence version replaced NM_008291.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U66827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGAAGC TCTTCATTGC TGCAGGGCTC TTCGTGGGCC TGGTTTGCCT GGTGAAGTGC 
ATGAGGTTCT CGCAGCACCT TTTTCTGAGG TTCTGCAAGG CTTTGCCAAG CTCTTTCCTG 
CGATCAATGG GACAATGGGC AGTGATTACC GGAGCAGGCG ATGGCATCGG GAAAGCCTAT 
TCATTTGAGT TGGCCAGACA TGGACTCAAT GTTGTACTTA TTAGTCGGAC ACTGGAAAAG 
CTACAGACCA TTGCAGAAGA GATTGAGAGG ACCACTGGAA GCTGTGTGAA GATTGTACAA 
GCAGATTTTA CCAGAGAAGA CATCTATGAC CATATTAAAG AACACCTTGA AGGCTTAGAA 
ATAGGAATTT TAGTCAACAA CGTTGGAATG CTCCCCAGCT TTTTCCCAAG CCATTTCCTG 
AGCACTTCCG GTGAGAGCCA GAATCTCATC CACTGCAACA TTACCTCCGT AGTCAAGATG 
ACACAGCTTG TTCTCAAACA CATGGAGTCA AGGAGGAAAG GCCTCATCTT GAATATTTCT 
TCAGGCGCAG CCCTTCGTCC CTGGCCTCTT TACAGCCTGT ACTCAGCTTC CAAGGCTTTT 
GTGTACACAT TTTCCAAGGC TCTGAGTGTG GAATACAGAG ATAAAGGAAT CATTATTCAG 
GTGCTGACCC CTTATTCTAT TTCAACCCCA ATGACAAAGT ACCTAAATAA CAAGATGACC 
AAGACCGCCG ATGAGTTTGT TAAAGAATCC TTGAAATATG TCACGATCGG AGCTGAATCC 
TGTGGCTGCC TTGCTCATGA AATCATTGCA ATAATTCTGA ACCGGATCCC TTCCAGAATC 
TTCTATAGCA GCACCGCTCA ACGATTCCTC CTGACACGAT ACTCAGATTA CCTCAAACGC 
AACATCAGCA ACAGATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_032317.2
CDS74..991
Translation

Target ORF information:

RefSeq Version NM_008291.3
Organism Mus musculus(house mouse)
Definition Mus musculus hydroxysteroid (17-beta) dehydrogenase 3 (Hsd17b3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_008291.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGAAGC TCTTCATTGC TGCAGGGCTC TTCGTGGGCC TGGTTTGCCT GGTGAAGTGC 
ATGAGGTTCT CGCAGCACCT TTTTCTGAGG TTCTGCAAGG CTTTGCCAAG CTCTTTCCTG 
CGATCAATGG GACAATGGGC AGTGATTACC GGAGCAGGCG ATGGCATCGG GAAAGCCTAT 
TCATTTGAGT TGGCCAGACA TGGACTCAAT GTTGTACTTA TTAGTCGGAC ACTGGAAAAG 
CTACAGACCA TTGCAGAAGA GATTGAGAGG ACCACTGGAA GCTGTGTGAA GATTGTACAA 
GCAGATTTTA CCAGAGAAGA CATCTATGAC CATATTAAAG AACACCTTGA AGGCTTAGAA 
ATAGGAATTT TAGTCAACAA CGTTGGAATG CTCCCCAGCT TTTTCCCAAG CCATTTCCTG 
AGCACTTCCG GTGAGAGCCA GAATCTCATC CACTGCAACA TTACCTCCGT AGTCAAGATG 
ACACAGCTTG TTCTCAAACA CATGGAGTCA AGGAGGAAAG GCCTCATCTT GAATATTTCT 
TCAGGCGCAG CCCTTCGTCC CTGGCCTCTT TACAGCCTGT ACTCAGCTTC CAAGGCTTTT 
GTGTACACAT TTTCCAAGGC TCTGAGTGTG GAATACAGAG ATAAAGGAAT CATTATTCAG 
GTGCTGACCC CTTATTCTAT TTCAACCCCA ATGACAAAGT ACCTAAATAA CAAGATGACC 
AAGACCGCCG ATGAGTTTGT TAAAGAATCC TTGAAATATG TCACGATCGG AGCTGAATCC 
TGTGGCTGCC TTGCTCATGA AATCATTGCA ATAATTCTGA ACCGGATCCC TTCCAGAATC 
TTCTATAGCA GCACCGCTCA ACGATTCCTC CTGACACGAT ACTCAGATTA CCTCAAACGC 
AACATCAGCA ACAGATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu48674
Clone ID Related Accession (Same CDS sequence) XM_006517108.3
Accession Version XM_006517108.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 879bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Mus musculus(house mouse)
Product testosterone 17-beta-dehydrogenase 3 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006517108.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAACACA CCCAGAGCCT CCTCAGAGGA GATCTGGCGG GCACCCAGGC CACTTGCCCT 
GGGAATCACA CGGGGATAAA GACCAGGTCC AGCAGCATCT CCAGCAAGAC AGCTCCAGAG 
GAGGCCATGG AGAAGCTCTT CATTGCTGCA GGGCTCTTCG TGGGCCTGGT TTGCCTGGTG 
AAGTGCATGA GGTTCTCGCA GCACCTTTTT CTGAGGTTCT GCAAGGCTTT GCCAAGCTCT 
TTCCTGCGAT CAATGGGACA ATGGGCAGTG ATTACCGGAG CAGGCGATGG CATCGGGAAA 
GCCTATTCAT TTGAGTTGGC CAGACATGGA CTCAATGTTG TACTTATTAG TCGGACACTG 
GAAAAGCTAC AGACCATTGC AGAAGAGATT GAGAGGACCA CTGGAAGCTG TGTGAAGATT 
GTACAAGCAG ATTTTACCAG AGAAGACATC TATGACCATA TTAAAGAACA CCTTGAAGGC 
TTAGAAATAG GAATTTTAGT CAACAACGTT GGAATGCTCC CCAGCTTTTT CCCAAGCCAT 
TTCCTGAGCA CTTCCGGTGA GAGCCAGAAT CTCATCCACT GCAACATTAC CTCCGTAGTC 
AAGATGACAC AGCTTGTTCT CAAACACATG GAGTCAAGGA GGAAAGGCCT CATCTTGAAT 
ATTTCTTCAG GCGCAGCCCT TCGTCCCTGG CCTCTTTACA GCCTGTACTC AGCTTCCAAG 
GCTTTTGTGT ACACATTTTC CAAGGCTCTG AGTGTGGAAT ACAGAGATAA AGGAATCATT 
ATTCAGGTTG TGCATGTGAA GATGGGCTGG ACTGGGCTAT TGGGTTCCCC TGACCAAGAC 
CAGGCCAACT GTTGCCTCCA CAATCCCTCC TGCTGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006517171.1
CDS9..887
Translation

Target ORF information:

RefSeq Version XM_006517108.3
Organism Mus musculus(house mouse)
Definition Mus musculus hydroxysteroid (17-beta) dehydrogenase 3 (Hsd17b3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006517108.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAACACA CCCAGAGCCT CCTCAGAGGA GATCTGGCGG GCACCCAGGC CACTTGCCCT 
GGGAATCACA CGGGGATAAA GACCAGGTCC AGCAGCATCT CCAGCAAGAC AGCTCCAGAG 
GAGGCCATGG AGAAGCTCTT CATTGCTGCA GGGCTCTTCG TGGGCCTGGT TTGCCTGGTG 
AAGTGCATGA GGTTCTCGCA GCACCTTTTT CTGAGGTTCT GCAAGGCTTT GCCAAGCTCT 
TTCCTGCGAT CAATGGGACA ATGGGCAGTG ATTACCGGAG CAGGCGATGG CATCGGGAAA 
GCCTATTCAT TTGAGTTGGC CAGACATGGA CTCAATGTTG TACTTATTAG TCGGACACTG 
GAAAAGCTAC AGACCATTGC AGAAGAGATT GAGAGGACCA CTGGAAGCTG TGTGAAGATT 
GTACAAGCAG ATTTTACCAG AGAAGACATC TATGACCATA TTAAAGAACA CCTTGAAGGC 
TTAGAAATAG GAATTTTAGT CAACAACGTT GGAATGCTCC CCAGCTTTTT CCCAAGCCAT 
TTCCTGAGCA CTTCCGGTGA GAGCCAGAAT CTCATCCACT GCAACATTAC CTCCGTAGTC 
AAGATGACAC AGCTTGTTCT CAAACACATG GAGTCAAGGA GGAAAGGCCT CATCTTGAAT 
ATTTCTTCAG GCGCAGCCCT TCGTCCCTGG CCTCTTTACA GCCTGTACTC AGCTTCCAAG 
GCTTTTGTGT ACACATTTTC CAAGGCTCTG AGTGTGGAAT ACAGAGATAA AGGAATCATT 
ATTCAGGTTG TGCATGTGAA GATGGGCTGG ACTGGGCTAT TGGGTTCCCC TGACCAAGAC 
CAGGCCAACT GTTGCCTCCA CAATCCCTCC TGCTGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice.
Endocrinology157(12)4899-4913(2016 Dec)
Umehara T,Kawashima I,Kawai T,Hoshino Y,Morohashi KI,Shima Y,Zeng W,Richards JS,Shimada M


book

Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.
Endocrinology157(3)1222-33(2016 Mar)
Inoue M,Shima Y,Miyabayashi K,Tokunaga K,Sato T,Baba T,Ohkawa Y,Akiyama H,Suyama M,Morohashi K


book

Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation.
Proceedings of the National Academy of Sciences of the United States of America112(13)4003-8(2015 Mar)
Zhang L,Chen M,Wen Q,Li Y,Wang Y,Wang Y,Qin Y,Cui X,Yang L,Huff V,Gao F