Gene Symbol | LAT |
Entrez Gene ID | 16797 |
Full Name | linker for activation of T cells |
Synonyms | p36-38,pp36 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
ORF » Species Summary » Mus musculus » LAT cDNA ORF clone
Gene Symbol | LAT |
Entrez Gene ID | 16797 |
Full Name | linker for activation of T cells |
Synonyms | p36-38,pp36 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_030242172.1 | XP_030098032.1 | linker for activation of T-cells family member 1 isoform X3 |
XM_006507397.2 | XP_006507460.2 | linker for activation of T-cells family member 1 isoform X2 |
XM_006507396.3 | XP_006507459.3 | linker for activation of T-cells family member 1 isoform X1 |
XM_006507396.2 | XP_006507459.2 | linker for activation of T-cells family member 1 isoform X1 |
XM_006507397.3 | XP_006507460.2 | linker for activation of T-cells family member 1 isoform X2 |
XM_006507398.4 | XP_006507461.1 | linker for activation of T-cells family member 1 isoform X4 |
NM_010689.3 | NP_034819.1 | linker for activation of T-cells family member 1 precursor |
XM_006507398.3 | XP_006507461.1 | linker for activation of T-cells family member 1 isoform X3 |
NM_010689.2 | NP_034819.1 | linker for activation of T-cells family member 1 precursor |
The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.
Loviglio MN, Arbogast T, J?nch AE, Collins SC, Popadin K, Bonnet CS, Giannuzzi G, Maillard AM, Jacquemont S, , Yalcin B, Katsanis N, Golzio C, Reymond A
American journal of human genetics101(4)564-577(2017 Oct)
The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.
Dolezal E, Infantino S, Drepper F, B?rsig T, Singh A, Wossning T, Fiala GJ, Minguet S, Warscheid B, Tarlinton DM, Jumaa H, Medgyesi D, Reth M
Nature immunology18(8)911-920(2017 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
this study shows that the site-specific delivery of linker for activation of T cells (LAT) in asthmatic mouse model
Title: LAT alleviates Th2/Treg imbalance in an OVA-induced allergic asthma mouse model through LAT-PLC-?1 interaction.
IFT20 is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
Title: IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.
The result indicate that LAT-PLCg1 interaction is important for controlling IL-6 production by T cells and demonstrate a critical role of IL-6 in the development of the lymphoproliferative syndrome.
Title: The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
provide evidence that CD28 and the TCR complex regulate NF-kappaB via different signaling modules of GRB-2/VAV1 and LAT/ADAP pathways respectively.
Title: TCR and CD28 activate the transcription factor NF-?B in T-cells via distinct adaptor signaling complexes.
miR-155 regulates the delicate balance between PAK1-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
Title: miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.
The following LAT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu39334 | |
Clone ID Related Accession (Same CDS sequence) | XM_006507398.4 , XM_006507398.3 | |
Accession Version | XM_006507398.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | linker for activation of T-cells family member 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006507398.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAGCAC TTCCACAGAG AGTCACTTCC TTCCCACCCC TGAGGCAGCC AGACCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006507461.1 |
CDS | 448..990 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006507398.3 |
1 | ATGACAGCAC TTCCACAGAG AGTCACTTCC TTCCCACCCC TGAGGCAGCC AGACCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu68121 | |
Clone ID Related Accession (Same CDS sequence) | XM_006507396.2 | |
Accession Version | XM_006507396.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | linker for activation of T-cells family member 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006507396.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006507459.2 |
CDS | 337..1035 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006507396.2 |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu68122 | |
Clone ID Related Accession (Same CDS sequence) | XM_006507397.2 , XM_006507397.3 | |
Accession Version | XM_006507397.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | linker for activation of T-cells family member 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006507397.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006507460.2 |
CDS | 338..1024 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006507397.2 |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22777 | |
Clone ID Related Accession (Same CDS sequence) | NM_010689.2 | |
Accession Version | NM_010689.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-14 | |
Organism | Mus musculus(House mouse) | |
Product | linker for activation of T-cells family member 1 precursor | |
Comment |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034819.1 |
Translation |
Target ORF information:
Target ORF information:
|
NM_010689.2 |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu76898 | |
Clone ID Related Accession (Same CDS sequence) | NM_010689.3 | |
Accession Version | NM_010689.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 729bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | linker for activation of T-cells family member 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC125322.4, AK134003.1 and BE947351.1. On Nov 24, 2015 this sequence version replaced NM_010689.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF036907.1, AK134003.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034819.1 |
CDS | 319..1047 |
Translation |
Target ORF information:
Target ORF information:
|
NM_010689.3 |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu39334 | |
Clone ID Related Accession (Same CDS sequence) | XM_006507398.4 , XM_006507398.3 | |
Accession Version | XM_006507398.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | linker for activation of T-cells family member 1 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006507398.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAGCAC TTCCACAGAG AGTCACTTCC TTCCCACCCC TGAGGCAGCC AGACCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006507461.1 |
CDS | 447..989 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006507398.4 |
1 | ATGACAGCAC TTCCACAGAG AGTCACTTCC TTCCCACCCC TGAGGCAGCC AGACCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu68122 | |
Clone ID Related Accession (Same CDS sequence) | XM_006507397.2 , XM_006507397.3 | |
Accession Version | XM_006507397.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | linker for activation of T-cells family member 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006507397.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006507460.2 |
CDS | 336..1022 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006507397.3 |
1 | ATGGAAGCAG ACGCCTTGAG CCCGGTGGGG CTGGGCCTCC TGCTGCTGCC CTTCTTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu89375 | |
Clone ID Related Accession (Same CDS sequence) | XM_006507396.3 | |
Accession Version | XM_006507396.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | linker for activation of T-cells family member 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006507396.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATTTCCT GCCCTCACCA CAGCTTCCTG TCGCACGCGG TGGTGAGCAG GAGAGGCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006507459.3 |
CDS | 117..1154 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006507396.3 |
1 | ATGATTTCCT GCCCTCACCA CAGCTTCCTG TCGCACGCGG TGGTGAGCAG GAGAGGCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu89376 | |
Clone ID Related Accession (Same CDS sequence) | XM_030242172.1 | |
Accession Version | XM_030242172.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | linker for activation of T-cells family member 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATTTCCT GCCCTCACCA CAGCTTCCTG TCGCACGCGG TGGTGAGCAG GAGAGGCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030098032.1 |
CDS | 117..1037 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030242172.1 |
1 | ATGATTTCCT GCCCTCACCA CAGCTTCCTG TCGCACGCGG TGGTGAGCAG GAGAGGCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs. |
The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex. |