Gene Symbol | Lcat |
Entrez Gene ID | 16816 |
Full Name | lecithin cholesterol acyltransferase |
Synonyms | AI046659,D8Wsu61e |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Lcat cDNA ORF clone
Gene Symbol | Lcat |
Entrez Gene ID | 16816 |
Full Name | lecithin cholesterol acyltransferase |
Synonyms | AI046659,D8Wsu61e |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008490.2 | NP_032516.2 | phosphatidylcholine-sterol acyltransferase precursor |
Gallus gallus (chicken) | LCAT | XP_414027.4 |
Homo sapiens (human) | LCAT | NP_000220.1 |
Pan troglodytes (chimpanzee) | LCAT | XP_001166500.1 |
Mus musculus (house mouse) | Lcat | NP_032516.2 |
Canis lupus familiaris (dog) | LCAT | XP_851673.1 |
Danio rerio (zebrafish) | LOC793137 | XP_001332828.3 |
Xenopus tropicalis (tropical clawed frog) | lcat | NP_001005715.1 |
Bos taurus (cattle) | LCAT | NP_001039534.1 |
Rattus norvegicus (Norway rat) | Lcat | NP_058720.2 |
Lipoprotein X Causes Renal Disease in LCAT Deficiency.
Ossoli A, Neufeld EB, Thacker SG, Vaisman B, Pryor M, Freeman LA, Brantner CA, Baranova I, Francone NO, Demosky SJ Jr, Vitali C, Locatelli M, Abbate M, Zoja C, Franceschini G, Calabresi L, Remaley AT
PloS one11(2)e0150083(2016)
Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-dependent Manner.
Nesan D, Tavallaee G, Koh D, Bashiri A, Abdin R, Ng DS
The Journal of biological chemistry290(51)30514-29(2015 Dec)
Lack of LCAT reduces the LPS-neutralizing capacity of HDL and enhances LPS-induced inflammation in mice.
Petropoulou PI, Berb?e JF, Theodoropoulos V, Hatziri A, Stamou P, Karavia EA, Spyridonidis A, Karagiannides I, Kypreos KE
Biochimica et biophysica acta1852(10 Pt A)2106-15(2015 Oct)
Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis.
Roghani A, Welch C, Xia Y, Liu Y, Peter D, Finn JP, Edwards RH, Lusis AJ
Mammalian genome : official journal of the International Mammalian Genome Society7(5)393-4(1996 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
increased cholesterol esterification by LCAT is atheroprotective
Title: Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice.
Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.2- and 2.9-fold increase, respectively.
Title: The Effect of Natural LCAT Mutations on the Biogenesis of HDL.
Taken together, these results suggest that apoE-containing discoidal HDLs do not require LCAT-dependent maturation to mediate efficient Abeta clearance
Title: LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice.
DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
Title: DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
adrenal glucocorticoid function in LCAT knockout (KO) mice
Title: LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function.
The following Lcat gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lcat cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu20458 | |
Clone ID Related Accession (Same CDS sequence) | NM_008490.2 | |
Accession Version | NM_008490.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | phosphatidylcholine-sterol acyltransferase precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI574112.1, AK149476.1 and AI046659.1. On Jul 2, 2009 this sequence version replaced NM_008490.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028861.1, AK149476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGGCTGC CTGGCTCCCC ATGGCAGCGG GTGCTGTTGC TGTTGGGGCT ACTGCTCCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032516.2 |
CDS | 25..1341 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008490.2 |
1 | ATGGGGCTGC CTGGCTCCCC ATGGCAGCGG GTGCTGTTGC TGTTGGGGCT ACTGCTCCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Lipoprotein X Causes Renal Disease in LCAT Deficiency. |
Lecithin:Cholesterol Acyltransferase (LCAT) Deficiency Promotes Differentiation of Satellite Cells to Brown Adipocytes in a Cholesterol-dependent Manner. |
Lack of LCAT reduces the LPS-neutralizing capacity of HDL and enhances LPS-induced inflammation in mice. |
Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis. |