Gene Symbol | Lhx4 |
Entrez Gene ID | 16872 |
Full Name | LIM homeobox protein 4 |
Synonyms | A330062J17Rik,Gsh-4,Gsh4 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Lhx4 cDNA ORF clone
gRNAs
Gene Symbol | Lhx4 |
Entrez Gene ID | 16872 |
Full Name | LIM homeobox protein 4 |
Synonyms | A330062J17Rik,Gsh-4,Gsh4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_010712.2 | NP_034842.2 | LIM/homeobox protein Lhx4 |
XM_006529169.2 | XP_006529232.1 | LIM/homeobox protein Lhx4 isoform X1 |
Homo sapiens (human) | LHX4 | NP_203129.1 |
Pan troglodytes (chimpanzee) | LHX4 | XP_524984.3 |
Mus musculus (house mouse) | Lhx4 | NP_034842.2 |
Danio rerio (zebrafish) | lhx4 | NP_001116445.1 |
LOC716454 | XP_001115086.1 | |
Canis lupus familiaris (dog) | LHX4 | XP_547420.2 |
Bos taurus (cattle) | LHX4 | NP_001179714.1 |
Gallus gallus (chicken) | LHX4 | XP_001235592.3 |
Rattus norvegicus (Norway rat) | Lhx4 | NP_001101818.1 |
Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP
Development (Cambridge, England)144(18)3289-3302(2017 09)
ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons.
Kim KT, Kim N, Kim HK, Lee H, Gruner HN, Gergics P, Park C, Mastick GS, Park HC, Song MR
Scientific reports636491(2016 Nov)
Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.
Rousso DL, Qiao M, Kagan RD, Yamagata M, Palmiter RD, Sanes JR
Cell reports15(9)1930-44(2016 05)
Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.
Mardaryev AN, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, Sharov AA, Jahoda CA, Fessing MY, Benitah SA, Xu GL, Botchkarev VA
The Journal of cell biology212(1)77-89(2016 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
conditional deletion of Shh in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3/Lhx4 expression in RP epithelium.
Title: Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
We discovered that expression of Cdkn1a is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 mutants. Lhx4 mutants exhibit reduced cyclin D1 expression and have auxiliary pouch-like structures.
Title: Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia.
X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4.Isl2 complex exhibit many similarities with that of Lhx3.Isl1; structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.
Title: Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.
Successful purification and crystallization of an engineered complex comprising the LIM domains of motor neuron protein Lhx4 and the Lim binding domain of Isl2 (islet 2 protein) are reported.
Title: Crystallization and diffraction of an Lhx4-Isl2 complex.
Results show that Lhx3 exhibits specific spatial and temporal expression in the mouse placenta, but that absence of both LHX3 and 4 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr.
Title: Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.
The following Lhx4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lhx4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu06686 | |
Clone ID Related Accession (Same CDS sequence) | NM_010712.2 | |
Accession Version | NM_010712.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | LIM/homeobox protein Lhx4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC049834.1 and AC117598.7. On Jun 19, 2008 this sequence version replaced NM_010712.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC049834.1, AF135415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164142 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGATGCAGA GCGCGGCTGT CCCCGCGGAG GGGGCTGTCA AGGGGCTCCC GGAGATGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034842.2 |
CDS | 151..1323 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGATGCAGA GCGCGGCTGT CCCCGCGGAG GGGGCTGTCA AGGGGCTCCC GGAGATGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu27928 | |
Clone ID Related Accession (Same CDS sequence) | XM_006529169.2 | |
Accession Version | XM_006529169.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | LIM/homeobox protein Lhx4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006529169.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGCTGG CTGACAGATG CTTCTCCAGG GCCGGCAGTG TCTACTGCAA GGAAGATTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006529232.1 |
CDS | 300..1289 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCAGCTGG CTGACAGATG CTTCTCCAGG GCCGGCAGTG TCTACTGCAA GGAAGATTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. |
ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons. |
Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. |
Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. |