Mt3 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Mt3 |
| Entrez Gene ID | 17751 |
| Full Name | metallothionein 3 |
| Synonyms | Mt-3 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_013603.2 | NP_038631.1 | metallothionein-3 |
Related articles in PubMed
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)
Metallothionein-3 modulates the amyloid ? endocytosis of astrocytes through its effects on actin polymerization.
Lee SJ, Seo BR, Koh JY
Molecular brain8(1)84(2015 Dec)
The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice.
Byun HR, Choi JA, Koh JY
Metallomics : integrated biometal science6(9)1748-57(2014 Sep)
The expression of MTNR3 and nuclear receptors in murine leucocytes.
Cernysiov V, Bozaite R, Mauricas M, Girkontaite I
In vivo (Athens, Greece)28(5)827-30(2014 Sep-Oct)
In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein.
Artells E, Palacios O, Capdevila M, Atrian S
The FEBS journal281(6)1659-78(2014 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the absence of Mt3 reduces Abeta uptake in astrocytes through an abnormality in actin polymerization.
Title: Metallothionein-3 modulates the amyloid ? endocytosis of astrocytes through its effects on actin polymerization.
Mt3 may act through PDE3a to play a key role in Zinc dyshomeostasis and cell death in streptozotocin-treated islets.
Title: The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice.
Circadian time and lighting could be involved in the regulation of the expression of melatonin receptors MTNR3 and Rorc.
Title: The expression of MTNR3 and nuclear receptors in murine leucocytes.
The entire MT3 peptide shows a high capacity to bind Cu(+) , provided that this occurs in a nonoxidative milieux. This reflects a peculiar property of this MT isoform, which senses different Cu contents in the environment in which it is synthesized.
Title: In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein.
Zn released from MT3 may contribute to VEGF induction.
Title: Methallothionein-3 contributes to vascular endothelial growth factor induction in a mouse model of choroidal neovascularization.
The following Mt3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mt3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu23241 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_013603.2 | |
| Accession Version | NM_013603.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | metallothionein-3 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK140209.1 and AC131733.3. On Jul 10, 2009 this sequence version replaced NM_013603.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU850905.1, AK140209.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGACCCTG AGACCTGCCC CTGTCCTACT GGTGGTTCCT GCACCTGCTC GGACAAATGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_038631.1 |
| CDS | 194..400 |
| Misc Feature(1) | 62..64 |
| Misc Feature(2) | 194..283 |
| Misc Feature(3) | 194..196 |
| Misc Feature(4) | 209..397 |
| Misc Feature(5) | 284..397 |
| Misc Feature(6) | 290..292 |
| Exon (1) | 1..224 |
| Exon (2) | 225..290 |
| Exon (3) | 291..538 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_013603.2 |
ORF Insert Sequence:
1 | ATGGACCCTG AGACCTGCCC CTGTCCTACT GGTGGTTCCT GCACCTGCTC GGACAAATGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
|
Metallothionein-3 modulates the amyloid ? endocytosis of astrocytes through its effects on actin polymerization. |
|
The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice. |
|
The expression of MTNR3 and nuclear receptors in murine leucocytes. |
|
In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein. |