Gene Symbol | Nsf |
Entrez Gene ID | 18195 |
Full Name | N-ethylmaleimide sensitive fusion protein |
Synonyms | AI316878,AU020090,AU067812,SKD2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nsf cDNA ORF clone
Gene Symbol | Nsf |
Entrez Gene ID | 18195 |
Full Name | N-ethylmaleimide sensitive fusion protein |
Synonyms | AI316878,AU020090,AU067812,SKD2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008740.4 | NP_032766.2 | vesicle-fusing ATPase |
Pan troglodytes (chimpanzee) | NSF | XP_511626.3 |
Canis lupus familiaris (dog) | NSF | XP_548044.2 |
Mus musculus (house mouse) | Nsf | NP_032766.2 |
Drosophila melanogaster (fruit fly) | comt | NP_001259506.1 |
Saccharomyces cerevisiae (baker's yeast) | SEC18 | NP_009636.3 |
Gallus gallus (chicken) | NSF | NP_001019627.1 |
Danio rerio (zebrafish) | nsfa | NP_001037793.1 |
Neurospora crassa | NCU03387 | XP_956834.1 |
Xenopus tropicalis (tropical clawed frog) | nsf | NP_001072788.1 |
Bos taurus (cattle) | NSF | XP_002696103.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012684 | XP_307148.3 |
Schizosaccharomyces pombe (fission yeast) | sec18 | NP_594690.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_02418 | XP_003709204.1 |
NSF | XP_002800596.1 | |
Caenorhabditis elegans (roundworm) | nsf-1 | NP_001076603.1 |
Caenorhabditis elegans (roundworm) | nsf-1 | NP_001076604.1 |
Homo sapiens (human) | NSF | NP_006169.2 |
Rattus norvegicus (Norway rat) | Nsf | NP_068516.1 |
Drosophila melanogaster (fruit fly) | Nsf2 | NP_788676.1 |
Kluyveromyces lactis | KLLA0C14520g | XP_452850.1 |
Eremothecium gossypii | AGOS_AER169C | NP_985027.1 |
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
Li J, Zhang W, Yang H, Howrigan DP, Wilkinson B, Souaiaia T, Evgrafov OV, Genovese G, Clementel VA, Tudor JC, Abel T, Knowles JA, Neale BM, Wang K, Sun F, Coba MP
Nature neuroscience20(8)1150-1161(2017 Aug)
Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.
He E, Wierda K, van Westen R, Broeke JH, Toonen RF, Cornelisse LN, Verhage M
Nature communications815915(2017 Jun)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
N-Ethylmaleimide Sensitive Factor (NSF) Inhibition Prevents Vascular Instability following Gram-Positive Pulmonary Challenge.
Lee JY, Linge HM, Ochani K, Lin K, Miller EJ
PloS one11(6)e0157837(2016)
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
Belluzzi E, Gonnelli A, Cirnaru MD, Marte A, Plotegher N, Russo I, Civiero L, Cogo S, Carrion MP, Franchin C, Arrigoni G, Beltramini M, Bubacco L, Onofri F, Piccoli G, Greggio E
Molecular neurodegeneration111(2016 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
NSF may have a role in vascular instability in gram-positive lung infections
Title: N-Ethylmaleimide Sensitive Factor (NSF) Inhibition Prevents Vascular Instability following Gram-Positive Pulmonary Challenge.
that mutant LRRK2 may impair synaptic vesicle dynamics via aberrant phosphorylation of N-ethylmaleimide sensitive fusion
Title: LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
identify conserved sequences in the 3'UTR of NSF as miR-33 responsive elements and show that Nsf is specifically recruited to the RNA-induced silencing complex following induction of miR-33
Title: Control of very low-density lipoprotein secretion by N-ethylmaleimide-sensitive factor and miR-33.
Arr1 and NSF interaction are necessary for both maintenance and modulation of normal photoreceptor synaptic regulation and NSF-RP2 interaction may play an important role in membrane protein trafficking in the photoreceptor.
Title: Potential cellular functions of N-ethylmaleimide sensitive factor in the photoreceptor.
These findings identify new roles for N-ethylmaleimide-sensitive factor and protein kinase C epsilon in regulating synaptic inhibition through downregulation of GABA(A) receptors
Title: GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor.
The following Nsf gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nsf cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu16089 | |
Clone ID Related Accession (Same CDS sequence) | NM_008740.4 | |
Accession Version | NM_008740.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | vesicle-fusing ATPase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL603829.5 and AL596108.13. On Apr 27, 2007 this sequence version replaced NM_008740.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006627.1, SRR1660815.175815.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCGGGCC GGACTATGCA AGCTGCGAGA TGCCCTACTG ATGAATTATC TTTAAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032766.2 |
CDS | 76..2310 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008740.4 |
1 | ATGGCGGGCC GGACTATGCA AGCTGCGAGA TGCCCTACTG ATGAATTATC TTTAAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. |
Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles. |
High-throughput discovery of novel developmental phenotypes. |
N-Ethylmaleimide Sensitive Factor (NSF) Inhibition Prevents Vascular Instability following Gram-Positive Pulmonary Challenge. |
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate. |