Orm1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Orm1
Entrez Gene ID	18405
Full Name	orosomucoid 1
Synonyms	Agp-1,Agp-2,Orm-1
General protein information	Preferred Names orosomucoid 1 Names alpha-1-acid glycoprotein 1 AGP 1 OMD 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 B3\|4 33.96 cM
Summary	This gene encodes a member of the lipocalin family of proteins. The encoded protein is an abundant acute-phase protein that is synthesized by hepatocytes in response to cytokines during the acute phase response. The encoded protein may regulate inflammation and metabolism. This gene is present in a gene cluster on chromosome 4. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008768.2	NP_032794.1	alpha-1-acid glycoprotein 1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Orm2	NP_035146.1
Mus musculus (house mouse)	Orm1	NP_032794.1
Mus musculus (house mouse)	Orm3	NP_038651.2

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.
Qin XY, Hara M, Arner E, Kawaguchi Y, Inoue I, Tatsukawa H, Furutani Y, Nagatsuma K, Matsuura T, Wei F, Kikuchi J, Sone H, Daub C, Kawaji H, Lassmann T, Itoh M, Suzuki H, Carninci P, Hayashizaki Y, , Kokudo N, Forrest ARR, Kojima S
EBioMedicine24257-266(2017 Oct)

The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway.
Sun Y, Yang Y, Qin Z, Cai J, Guo X, Tang Y, Wan J, Su DF, Liu X
Diabetes65(6)1630-41(2016 06)

Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.
Lei H, Sun Y, Luo Z, Yourek G, Gui H, Yang Y, Su DF, Liu X
Scientific reports618839(2016 Jan)

Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse.
Wu L, Jiang Y, Zhu J, Wen Z, Xu X, Xu X, Xie Y, Yang L, Xu L, Lan W, Xu G, Liu X
Brain research bulletin10988-98(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that decreasing the Orm1 expression via inhibition of the NF-kappaB pathway could be a possible mechanism involved in the aggravation of BBB disruption after stroke by VEGF.
Title: Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse.

alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Title: ?(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.

Together, these data suggest that alpha1-acid glycoprotein may be involved in reduction of neutrophil migration and increased susceptibility to sepsis in diabetic mice.
Title: ?1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice.

ORM integrates inflammatory and metabolic signals to modulate immune responses to protect adipose tissue from excessive inflammation and thereby from metabolic dysfunction.
Title: Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation.

alpha-1 acid glycoprotein expression is increased by retinoids at the transcriptional level through two distinct DR1 retinoic acid responsive elements
Title: Retinoids increase alpha-1 acid glycoprotein expression at the transcriptional level through two distinct DR1 retinoic acid responsive elements.

The following Orm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Orm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02736	NM_008768.2 Latest version!	Mus musculus orosomucoid 1 (Orm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Orm1 ( NM_008768.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032794.1 Mus musculus orosomucoid 1 (Orm1), mRNA.

Price & Availability↑

CloneID	OMu02736
Clone ID Related Accession (Same CDS sequence)	NM_008768.2
Accession Version	NM_008768.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	alpha-1-acid glycoprotein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL683828.8, AK138985.1, AA611123.1 and AW113734.1. On Aug 21, 2015 this sequence version replaced NM_008768.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA494093.1, CA456410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCTGC ACACGGTTCT TATCATATTG AGCCTTCTGC CGATGTTGGA AGCTCAGAAC 
CCAGAACATG CCAACTTCAC CATAGGCGAA CCTATCACCA ATGAGACCCT GAGCTGGCTC 
TCTGACAAAT GGTTTTTCAT GGGTGCAGCT TTCAGAAAAC TCGAGTACAG GCAGGCAATT 
CAAACAATGC AGAGTGAATT TTTTTACCTT ACCACCAACT TGATAAACGA CACAATAGAG 
CTTCGGGAGT CTCAAACAAT AGGTGACCAG TGTGTCTATA ACTCCACCCA TCTAGGATTC 
CAGAGAGAAA ATGGGACCTT CTCCAAGTAT GAAGGAGGAG TAGAAACCTT TGCCCACCTT 
ATAGTGCTGA GGAAACATGG GGCCTTCATG CTTGCCTTTG ACCTCAAGGA TGAGAAGAAA 
CGGGGACTGT CCCTCTATGC CAAAAGGCCA GATATCACCC CGGAGCTGCG GGAAGTATTC 
CAGAAGGCTG TCACACACGT GGGCATGGAT GAATCAGAAA TCATATTTGT CGACTGGAAA 
AAGGATAGGT GCGGTCAGCA GGAGAAGAAG CAGCTTGAGT TGGGGAAGGA GACCAAGAAA 
GATCCTGAGG AAGGCCAGGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032794.1
CDS	43..666
Translation	MALHTVLIILSLLPMLEAQNPEHANFTIGEPITNETLSWLSDKWFFMGAAFRKLEYRQAIQTMQSEFFYLTTNLINDTIELRESQTIGDQCVYNSTHLGFQRENGTFSKYEGGVETFAHLIVLRKHGAFMLAFDLKDEKKRGLSLYAKRPDITPELREVFQKAVTHVGMDESEIIFVDWKKDRCGQQEKKQLELGKETKKDPEEGQA

Target ORF information:

RefSeq Version	NM_008768.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus orosomucoid 1 (Orm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008768.2

ORF Insert Sequence:

ATGGCGCTGC ACACGGTTCT TATCATATTG AGCCTTCTGC CGATGTTGGA AGCTCAGAAC 
CCAGAACATG CCAACTTCAC CATAGGCGAA CCTATCACCA ATGAGACCCT GAGCTGGCTC 
TCTGACAAAT GGTTTTTCAT GGGTGCAGCT TTCAGAAAAC TCGAGTACAG GCAGGCAATT 
CAAACAATGC AGAGTGAATT TTTTTACCTT ACCACCAACT TGATAAACGA CACAATAGAG 
CTTCGGGAGT CTCAAACAAT AGGTGACCAG TGTGTCTATA ACTCCACCCA TCTAGGATTC 
CAGAGAGAAA ATGGGACCTT CTCCAAGTAT GAAGGAGGAG TAGAAACCTT TGCCCACCTT 
ATAGTGCTGA GGAAACATGG GGCCTTCATG CTTGCCTTTG ACCTCAAGGA TGAGAAGAAA 
CGGGGACTGT CCCTCTATGC CAAAAGGCCA GATATCACCC CGGAGCTGCG GGAAGTATTC 
CAGAAGGCTG TCACACACGT GGGCATGGAT GAATCAGAAA TCATATTTGT CGACTGGAAA 
AAGGATAGGT GCGGTCAGCA GGAGAAGAAG CAGCTTGAGT TGGGGAAGGA GACCAAGAAA 
GATCCTGAGG AAGGCCAGGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.
EBioMedicine24257-266(2017 Oct)
Qin XY,Hara M,Arner E,Kawaguchi Y,Inoue I,Tatsukawa H,Furutani Y,Nagatsuma K,Matsuura T,Wei F,Kikuchi J,Sone H,Daub C,Kawaji H,Lassmann T,Itoh M,Suzuki H,Carninci P,Hayashizaki Y,,Kokudo N,Forrest ARR,Kojima S

The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway.
Diabetes65(6)1630-41(2016 06)
Sun Y,Yang Y,Qin Z,Cai J,Guo X,Tang Y,Wan J,Su DF,Liu X

Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.
Scientific reports618839(2016 Jan)
Lei H,Sun Y,Luo Z,Yourek G,Gui H,Yang Y,Su DF,Liu X

Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse.
Brain research bulletin10988-98(2014 Oct)
Wu L,Jiang Y,Zhu J,Wen Z,Xu X,Xu X,Xie Y,Yang L,Xu L,Lan W,Xu G,Liu X

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Orm1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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