Orm1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Orm1 |
| Entrez Gene ID | 18405 |
| Full Name | orosomucoid 1 |
| Synonyms | Agp-1,Agp-2,Orm-1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a member of the lipocalin family of proteins. The encoded protein is an abundant acute-phase protein that is synthesized by hepatocytes in response to cytokines during the acute phase response. The encoded protein may regulate inflammation and metabolism. This gene is present in a gene cluster on chromosome 4. [provided by RefSeq, Aug 2015]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_008768.2 | NP_032794.1 | alpha-1-acid glycoprotein 1 precursor |
| Mus musculus (house mouse) | Orm2 | NP_035146.1 |
| Mus musculus (house mouse) | Orm1 | NP_032794.1 |
| Mus musculus (house mouse) | Orm3 | NP_038651.2 |
Related articles in PubMed
Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.
Qin XY, Hara M, Arner E, Kawaguchi Y, Inoue I, Tatsukawa H, Furutani Y, Nagatsuma K, Matsuura T, Wei F, Kikuchi J, Sone H, Daub C, Kawaji H, Lassmann T, Itoh M, Suzuki H, Carninci P, Hayashizaki Y, , Kokudo N, Forrest ARR, Kojima S
EBioMedicine24257-266(2017 Oct)
The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway.
Sun Y, Yang Y, Qin Z, Cai J, Guo X, Tang Y, Wan J, Su DF, Liu X
Diabetes65(6)1630-41(2016 06)
Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.
Lei H, Sun Y, Luo Z, Yourek G, Gui H, Yang Y, Su DF, Liu X
Scientific reports618839(2016 Jan)
Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse.
Wu L, Jiang Y, Zhu J, Wen Z, Xu X, Xu X, Xie Y, Yang L, Xu L, Lan W, Xu G, Liu X
Brain research bulletin10988-98(2014 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study demonstrated that decreasing the Orm1 expression via inhibition of the NF-kappaB pathway could be a possible mechanism involved in the aggravation of BBB disruption after stroke by VEGF.
Title: Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse.
alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Title: ?(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Together, these data suggest that alpha1-acid glycoprotein may be involved in reduction of neutrophil migration and increased susceptibility to sepsis in diabetic mice.
Title: ?1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice.
ORM integrates inflammatory and metabolic signals to modulate immune responses to protect adipose tissue from excessive inflammation and thereby from metabolic dysfunction.
Title: Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation.
alpha-1 acid glycoprotein expression is increased by retinoids at the transcriptional level through two distinct DR1 retinoic acid responsive elements
Title: Retinoids increase alpha-1 acid glycoprotein expression at the transcriptional level through two distinct DR1 retinoic acid responsive elements.
The following Orm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Orm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu02736 | |
| Clone ID Related Accession (Same CDS sequence) | NM_008768.2 | |
| Accession Version | NM_008768.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-28 | |
| Organism | Mus musculus(house mouse) | |
| Product | alpha-1-acid glycoprotein 1 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL683828.8, AK138985.1, AA611123.1 and AW113734.1. On Aug 21, 2015 this sequence version replaced NM_008768.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA494093.1, CA456410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGCTGC ACACGGTTCT TATCATATTG AGCCTTCTGC CGATGTTGGA AGCTCAGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_032794.1 |
| CDS | 43..666 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_008768.2 |
ORF Insert Sequence:
1 | ATGGCGCTGC ACACGGTTCT TATCATATTG AGCCTTCTGC CGATGTTGGA AGCTCAGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes. |
|
The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway. |
|
Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance. |
|
Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse. |