Gene Symbol | Rp2 |
Entrez Gene ID | 19889 |
Full Name | retinitis pigmentosa 2 homolog |
Synonyms | AI662636,Rp2h |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Rp2 cDNA ORF clone
gRNAs
Gene Symbol | Rp2 |
Entrez Gene ID | 19889 |
Full Name | retinitis pigmentosa 2 homolog |
Synonyms | AI662636,Rp2h |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017318439.1 | XP_017173928.1 | protein XRP2 isoform X1 |
NM_001290644.1 | NP_001277573.1 | protein XRP2 isoform b |
NM_001290643.1 | NP_001277572.1 | protein XRP2 isoform a |
XM_017318439.2 | XP_017173928.1 | protein XRP2 isoform X1 |
NM_133669.5 | NP_598430.1 | protein XRP2 isoform a |
Mus musculus (house mouse) | Rp2h | NP_598430.1 |
Rattus norvegicus (Norway rat) | Rp2 | NP_001102482.1 |
Xenopus tropicalis (tropical clawed frog) | rp2 | XP_002937023.1 |
Pan troglodytes (chimpanzee) | RP2 | XP_521029.2 |
Canis lupus familiaris (dog) | RP2 | XP_548972.2 |
Bos taurus (cattle) | RP2 | NP_001030480.1 |
Gallus gallus (chicken) | RP2 | NP_001008680.1 |
Homo sapiens (human) | RP2 | NP_008846.2 |
Danio rerio (zebrafish) | rp2 | NP_998611.1 |
ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.
Wright ZC, Singh RK, Alpino R, Goldberg AF, Sokolov M, Ramamurthy V
Human molecular genetics25(10)2031-2044(2016 05)
Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (RP2)-knockout mice by gene replacement therapy.
Mookherjee S, Hiriyanna S, Kaneshiro K, Li L, Li Y, Li W, Qian H, Li T, Khanna H, Colosi P, Swaroop A, Wu Z
Human molecular genetics24(22)6446-58(2015 Nov)
Loss of retinitis pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in mice.
Li L, Rao KN, Zheng-Le Y, Hurd TW, Lillo C, Khanna H
Cytoskeleton (Hoboken, N.J.)72(9)447-54(2015 Sep)
Mistrafficking of prenylated proteins causes retinitis pigmentosa 2.
Zhang H, Hanke-Gogokhia C, Jiang L, Li X, Wang P, Gerstner CD, Frederick JM, Yang Z, Baehr W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology29(3)932-42(2015 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
this study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of X-linked retinitis pigmentosa
Title: ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.
we first performed detailed characterization of the Rp2-knockout (Rp2-KO) mice and observed early-onset cone dysfunction
Title: Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (RP2)-knockout mice by gene replacement therapy.
RP2 has a role in cone photoreceptor sensory cilium elongation in mice
Title: Loss of retinitis pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in mice.
Our studies suggest that RP2 contributes to the maintenance of photoreceptor function and that cone opsin mislocalization represents an early step in XLRP caused by RP2 mutations.
Title: Ablation of the X-linked retinitis pigmentosa 2 (Rp2) gene in mice results in opsin mislocalization and photoreceptor degeneration.
We propose that RP2 regulation of Arl3 is important for maintaining Golgi cohesion, facilitating the transport and docking of vesicles and thereby carrying proteins to the base of the photoreceptor connecting cilium for transport to the outer segment.
Title: The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium.
The following Rp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13938 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290643.1 , NM_133669.5 | |
Accession Version | NM_001290643.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1044bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-01 | |
Organism | Mus musculus(house mouse) | |
Product | protein XRP2 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132713.1 and BX294384.19. Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: AK132713.1, BC049698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTGCT GCTTCACTAA GAGGAGGAAG AGTGAAAAGG CTGAGGGAGA GGAGGAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277572.1 |
CDS | 256..1299 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGCTGCT GCTTCACTAA GAGGAGGAAG AGTGAAAAGG CTGAGGGAGA GGAGGAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13938 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290643.1 , NM_133669.5 | |
Accession Version | NM_133669.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1044bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-21 | |
Organism | Mus musculus(house mouse) | |
Product | protein XRP2 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132713.1, AK050418.1, AK162309.1 and BX294384.19. On Mar 15, 2014 this sequence version replaced NM_133669.4. Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK050418.1, AK162309.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTGCT GCTTCACTAA GAGGAGGAAG AGTGAAAAGG CTGAGGGAGA GGAGGAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_598430.1 |
CDS | 256..1299 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGCTGCT GCTTCACTAA GAGGAGGAAG AGTGAAAAGG CTGAGGGAGA GGAGGAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17145 | |
Clone ID Related Accession (Same CDS sequence) | XM_017318439.1 , NM_001290644.1 , XM_017318439.2 | |
Accession Version | NM_001290644.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-01 | |
Organism | Mus musculus(house mouse) | |
Product | protein XRP2 isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132713.1, AK033954.1, AK162309.1 and BX294384.19. On Mar 15, 2014 this sequence version replaced XM_006527573.1. Transcript Variant: This variant (3) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK033954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTTAGTG GACTGAAGGA TGAAACAGTA GGTCGCTTAC CTGGAAAAGT GGCAGGACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277573.1 |
CDS | 526..1458 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTTAGTG GACTGAAGGA TGAAACAGTA GGTCGCTTAC CTGGAAAAGT GGCAGGACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17145 | |
Clone ID Related Accession (Same CDS sequence) | XM_017318439.1 , NM_001290644.1 , XM_017318439.2 | |
Accession Version | XM_017318439.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | protein XRP2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTAGTG GACTGAAGGA TGAAACAGTA GGTCGCTTAC CTGGAAAAGT GGCAGGACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017173928.1 |
CDS | 359..1291 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTTAGTG GACTGAAGGA TGAAACAGTA GGTCGCTTAC CTGGAAAAGT GGCAGGACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17145 | |
Clone ID Related Accession (Same CDS sequence) | XM_017318439.1 , NM_001290644.1 , XM_017318439.2 | |
Accession Version | XM_017318439.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | protein XRP2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017318439.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTAGTG GACTGAAGGA TGAAACAGTA GGTCGCTTAC CTGGAAAAGT GGCAGGACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017173928.1 |
CDS | 675..1607 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTTAGTG GACTGAAGGA TGAAACAGTA GGTCGCTTAC CTGGAAAAGT GGCAGGACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment. |
Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (RP2)-knockout mice by gene replacement therapy. |
Loss of retinitis pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in mice. |
Mistrafficking of prenylated proteins causes retinitis pigmentosa 2. |