Slc10a2 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Slc10a2 |
| Entrez Gene ID | 20494 |
| Full Name | solute carrier family 10, member 2 |
| Synonyms | 9130221J18Rik,AI605518,ASBT,IBAT,ISBT |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_011388.2 | NP_035518.1 | ileal sodium/bile acid cotransporter |
| NM_011388.3 | NP_035518.1 | ileal sodium/bile acid cotransporter |
| Gallus gallus (chicken) | SLC10A2 | XP_425589.3 |
| Danio rerio (zebrafish) | slc10a2 | NP_956652.1 |
| Drosophila melanogaster (fruit fly) | CG9903 | NP_573132.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100487141 | XP_002933069.1 |
| Homo sapiens (human) | SLC10A2 | NP_000443.1 |
| Mus musculus (house mouse) | Slc10a2 | NP_035518.1 |
| Arabidopsis thaliana (thale cress) | AT2G26900 | NP_850089.1 |
| Canis lupus familiaris (dog) | SLC10A2 | NP_001002968.1 |
| Rattus norvegicus (Norway rat) | Slc10a2 | NP_058918.1 |
| Pan troglodytes (chimpanzee) | SLC10A2 | XP_522716.2 |
| SLC10A2 | XP_001095212.1 | |
| Bos taurus (cattle) | SLC10A2 | XP_002692028.2 |
| Oryza sativa (rice) | Os01g0645200 | NP_001043701.1 |
Related articles in PubMed
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS
Immunity47(6)1182-1196.e10(2017 Dec)
Cholesterol 7?-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Ferrell JM, Boehme S, Li F, Chiang JY
Journal of lipid research57(7)1144-54(2016 07)
Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids.
Raufman JP, Dawson PA, Rao A, Drachenberg CB, Heath J, Shang AC, Hu S, Zhan M, Polli JE, Cheng K
Carcinogenesis36(10)1193-200(2015 Oct)
Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.
Out C, Patankar JV, Doktorova M, Boesjes M, Bos T, de Boer S, Havinga R, Wolters H, Boverhof R, van Dijk TH, Smoczek A, Bleich A, Sachdev V, Kratky D, Kuipers F, Verkade HJ, Groen AK
Journal of hepatology63(3)697-704(2015 Sep)
Maternal bile acid transporter deficiency promotes neonatal demise.
Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD
Nature communications68186(2015 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In Asbt-deficient mice, the lack of bile acid uptake in the distal small intestine, which we recently documented using novel in vivo imaging results in more than 10-fold increased fecal bile acids
Title: Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids.
data support the concept that under physiological conditions microbiota stimulate Gata4, which suppresses Asbt expression
Title: Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.
ileal ASBT protein is degraded by a ubiquitin-dependent pathway in response to enterobacteria-associated bile acids
Title: Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids.
Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt(-/-)apoE(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1).
Title: Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE?/? mice.
The functional importance of proline and uncharged polar residues in the highly conserved region of mouse Slc10a2 was determined.
Title: Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107-Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression.
The following Slc10a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc10a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu20357 | |
| Clone ID Related Accession (Same CDS sequence) | NM_011388.2 , NM_011388.3 | |
| Accession Version | NM_011388.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-02-14 | |
| Organism | Mus musculus(House mouse) | |
| Product | ileal sodium/bile acid cotransporter | |
| Comment | ||
1 | ATGGATAACT CCTCTGTCTG TCCCCCAAAT GCAACTGTCT GCGAAGGCGA TTCCTGCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_035518.1 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_011388.2 |
ORF Insert Sequence:
1 | ATGGATAACT CCTCTGTCTG TCCCCCAAAT GCAACTGTCT GCGAAGGCGA TTCCTGCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu20357 | |
| Clone ID Related Accession (Same CDS sequence) | NM_011388.2 , NM_011388.3 | |
| Accession Version | NM_011388.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-22 | |
| Organism | Mus musculus(house mouse) | |
| Product | ileal sodium/bile acid cotransporter | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC110744.6. On May 24, 2016 this sequence version replaced NM_011388.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB002693.1, AY529655.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGATAACT CCTCTGTCTG TCCCCCAAAT GCAACTGTCT GCGAAGGCGA TTCCTGCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_035518.1 |
| CDS | 105..1151 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_011388.3 |
ORF Insert Sequence:
1 | ATGGATAACT CCTCTGTCTG TCCCCCAAAT GCAACTGTCT GCGAAGGCGA TTCCTGCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids. |
|
Cholesterol 7?-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. |
|
Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids. |
|
Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4. |
|
Maternal bile acid transporter deficiency promotes neonatal demise. |