Gene Symbol | Syn2 |
Entrez Gene ID | 20965 |
Full Name | synapsin II |
Synonyms | 2900074L19Rik,AI836018,AI841723 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Syn2 cDNA ORF clone
Gene Symbol | Syn2 |
Entrez Gene ID | 20965 |
Full Name | synapsin II |
Synonyms | 2900074L19Rik,AI836018,AI841723 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_013681.3 | NP_038709.1 | synapsin-2 isoform IIb |
NM_001111015.1 | NP_001104485.1 | synapsin-2 isoform IIa |
NM_001326560.1 | NP_001313489.1 | synapsin-2 isoform IIc |
Pan troglodytes (chimpanzee) | SYN2 | XP_001171832.2 |
Canis lupus familiaris (dog) | SYN2 | XP_541766.3 |
Mus musculus (house mouse) | Syn2 | NP_001104485.1 |
Danio rerio (zebrafish) | syn2a | NP_001002597.2 |
Bos taurus (cattle) | SYN2 | XP_002697179.2 |
Rattus norvegicus (Norway rat) | Syn2 | NP_001029192.1 |
Homo sapiens (human) | SYN2 | NP_598328.1 |
LOC695412 | XP_001086745.2 | |
Gallus gallus (chicken) | SYN2 | XP_003642037.2 |
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum.
Tan GH, Liu YY, Wang L, Li K, Zhang ZQ, Li HF, Yang ZF, Li Y, Li D, Wu MY, Yu CL, Long JJ, Chen RC, Li LX, Yin LP, Liu JW, Cheng XW, Shen Q, Shu YS, Sakimura K, Liao LJ, Wu ZY, Xiong ZQ
Cell research28(1)90-110(2018 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results reveal a new SynII function in the regulation of the time course of GABA release and demonstrate that this function is dependent on the interneuron subtype.
Title: Synapsin II Regulation of GABAergic Synaptic Transmission Is Dependent on Interneuron Subtype.
This study demonstrated that synapsin 2 regulating GABA Release from Hippocampal Interneurons.
Title: Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons.
Deletion of synapsin II, a presynaptic protein contributing to epilepsy predisposition in humans, leads to a loss of tonic inhibition in mouse hippocampal slices due to a dramatic decrease in presynaptic asynchronous GABA release.
Title: Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
In synapsin II(-) hippocampal neurons an overexcitable phenotype was observed.
Title: Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus.
This study demonstrated a seizure-inducing potential of regular handling in both Syn1KO and Syn2KO mice during a period between P21 and 4 1/2 months of age.
Title: Sensitive and critical periods in the development of handling induced seizures in mice lacking synapsins: differences between synapsin I and synapsin II knockouts.
The following Syn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Syn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu68829 | |
Clone ID Related Accession (Same CDS sequence) | NM_001326560.1 | |
Accession Version | NM_001326560.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-28 | |
Organism | Mus musculus(house mouse) | |
Product | synapsin-2 isoform IIc | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY772774.1, AK029181.1, CX207371.1, AK013810.1 and AV342495.1. On May 20, 2016 this sequence version replaced XM_011241271.1. Transcript Variant: This variant (IIc) differs in the 5' and 3' UTRs and has multiple coding region differences, including an alternate start codon and novel 3' coding region, compared to variant 1. It encodes isoform IIc which is shorter and has distinct N- and C-termini, compared to isoform IIa. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029181.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGGACAG AGAGAAATCC CTTTCACTTA AGGTCCTTCA GACCAGACTT TGTGCTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001313489.1 |
CDS | 81..1022 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001326560.1 |
1 | ATGAGGACAG AGAGAAATCC CTTTCACTTA AGGTCCTTCA GACCAGACTT TGTGCTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16343 | |
Clone ID Related Accession (Same CDS sequence) | NM_013681.3 | |
Accession Version | NM_013681.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-28 | |
Organism | Mus musculus(house mouse) | |
Product | synapsin-2 isoform IIb | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC147047.2, BY705489.1, BC066004.1, BM951908.1, BM114311.1, AK029181.1, CX207371.1, AK013810.1 and AV342495.1. On Nov 7, 2013 this sequence version replaced NM_013681.2. Transcript Variant: This variant (IIb) lacks two exons and its 3' terminal exon extends past a splice site that is used in variant IIa. This results in a novel 3' coding region and 3' UTR, compared to variant IIa. It encodes isoform IIb which is shorter and has a distinct C-terminus, compared to isoform IIa. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF096867.1, SRR1660815.6115.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGATGAACT TCCTGAGGCG CCGGCTGTCG GACAGCAGCT TCATCGCCAA CCTGCCCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_038709.1 |
CDS | 180..1619 |
Translation |
Target ORF information:
Target ORF information:
|
NM_013681.3 |
1 | ATGATGAACT TCCTGAGGCG CCGGCTGTCG GACAGCAGCT TCATCGCCAA CCTGCCCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23221 | |
Clone ID Related Accession (Same CDS sequence) | NM_001111015.1 | |
Accession Version | NM_001111015.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1761bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-28 | |
Organism | Mus musculus(house mouse) | |
Product | synapsin-2 isoform IIa | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC147047.2, BY705489.1, BC066004.1 and AC153907.1. Transcript Variant: This variant (IIa) encodes the longer isoform (IIa). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053427.1, SRR1660819.92320.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGATGAACT TCCTGAGGCG CCGGCTGTCG GACAGCAGCT TCATCGCCAA CCTGCCCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001104485.1 |
CDS | 180..1940 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001111015.1 |
1 | ATGATGAACT TCCTGAGGCG CCGGCTGTCG GACAGCAGCT TCATCGCCAA CCTGCCCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. |