Gene Symbol | Arid5a |
Entrez Gene ID | 214855 |
Full Name | AT rich interactive domain 5A (MRF1-like) |
Synonyms | D430024K22Rik,Mrf1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Arid5a cDNA ORF clone
Gene Symbol | Arid5a |
Entrez Gene ID | 214855 |
Full Name | AT rich interactive domain 5A (MRF1-like) |
Synonyms | D430024K22Rik,Mrf1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001172205.1 | NP_001165676.1 | AT-rich interactive domain-containing protein 5A isoform 1 |
NM_145996.4 | NP_666108.2 | AT-rich interactive domain-containing protein 5A isoform 3 |
NM_001290726.1 | NP_001277655.1 | AT-rich interactive domain-containing protein 5A isoform 5 |
XM_017319751.1 | XP_017175240.1 | AT-rich interactive domain-containing protein 5A isoform X1 |
NM_001290727.1 | NP_001277656.1 | AT-rich interactive domain-containing protein 5A isoform 6 |
XM_017319751.2 | XP_017175240.1 | AT-rich interactive domain-containing protein 5A isoform X1 |
NM_001172206.1 | NP_001165677.1 | AT-rich interactive domain-containing protein 5A isoform 2 |
Gallus gallus (chicken) | ARID5A | XP_004947689.1 |
Mus musculus (house mouse) | Arid5a | NP_001165677.1 |
Pan troglodytes (chimpanzee) | ARID5A | XP_515631.3 |
Canis lupus familiaris (dog) | ARID5A | XP_540165.2 |
Rattus norvegicus (Norway rat) | Arid5a | NP_001030106.1 |
Bos taurus (cattle) | ARID5A | NP_001030426.1 |
Homo sapiens (human) | ARID5A | NP_997646.1 |
Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a.
Higa M, Oka M, Fujihara Y, Masuda K, Yoneda Y, Kishimoto T
Proceedings of the National Academy of Sciences of the United States of America(2018 Jan)
Arid5a stabilizes OX40 mRNA in murine CD4
Hanieh H, Masuda K, Metwally H, Chalise JP, Mohamed M, Nyati KK, Standley DM, Li S, Higa M, Zaman MM, Kishimoto T
European journal of immunology(2017 Dec)
TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a.
Nyati KK, Masuda K, Zaman MM, Dubey PK, Millrine D, Chalise JP, Higa M, Li S, Standley DM, Saito K, Hanieh H, Kishimoto T
Nucleic acids research45(5)2687-2703(2017 Mar)
Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury.
Dubey PK, Masuda K, Nyati KK, -Uz Zaman MM, Chalise JP, Millrine D, Kai W, Ripley B, Kishimoto T
International immunology29(2)79-85(2017 02)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
data showed that regulation of Arid5a by NF-kappaB and MAPK signaling is required to maintain the balance of IL-6 mRNA expression
Title: TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a.
this study shows that Arid5a-deficient mice were highly refractory to bleomycin-induced lung injury
Title: Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury.
T cell-intrinsic role of Arid5a on fate decisions of naive CD4(+)T cells through selective stabilization of Stat3 mRNA.
Title: Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA.
Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.
Title: Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.
AT-rich interactive domain-containing protein 5a (Arid5a) cooperates with Sox9 to stimulate chondrocyte-specific transcription.
Title: Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.
The following Arid5a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arid5a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu00079 | |
Clone ID Related Accession (Same CDS sequence) | NM_001172206.1 | |
Accession Version | NM_001172206.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | AT-rich interactive domain-containing protein 5A isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY196834.1, AK149839.1 and AK029237.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI555214.1, BE382286.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCACCTC CGGCCAAAGG GAACACAGAG CAGTCAGAAG AAGGTGACCT CCCGCAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001165677.1 |
CDS | 101..1870 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001172206.1 |
1 | ATGGCACCTC CGGCCAAAGG GAACACAGAG CAGTCAGAAG AAGGTGACCT CCCGCAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu12105 | |
Clone ID Related Accession (Same CDS sequence) | NM_145996.4 | |
Accession Version | NM_145996.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1599bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | AT-rich interactive domain-containing protein 5A isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY196834.1, AK085015.1 and AK029237.1. On Feb 6, 2010 this sequence version replaced NM_145996.3. Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK029237.1, AK085015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAGCAC CTCCGGCCAA AGGGAACACA GAGCAGTCAG AAGAAGGTGA CCTCCCGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_666108.2 |
CDS | 101..1699 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145996.4 |
1 | ATGGCAGCAC CTCCGGCCAA AGGGAACACA GAGCAGTCAG AAGAAGGTGA CCTCCCGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14309 | |
Clone ID Related Accession (Same CDS sequence) | NM_001172205.1 | |
Accession Version | NM_001172205.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1773bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | AT-rich interactive domain-containing protein 5A isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY196834.1, AK149839.1 and AK029237.1. Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK156376.1, AK149839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAGCAC CTCCGGCCAA AGGGAACACA GAGCAGTCAG AAGAAGGTGA CCTCCCGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001165676.1 |
CDS | 101..1873 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001172205.1 |
1 | ATGGCAGCAC CTCCGGCCAA AGGGAACACA GAGCAGTCAG AAGAAGGTGA CCTCCCGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14335 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290726.1 , XM_017319751.1 , XM_017319751.2 | |
Accession Version | NM_001290726.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | AT-rich interactive domain-containing protein 5A isoform 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY196834.1, AK150170.1, AC132456.5, AK149839.1 and AK029237.1. Transcript Variant: This variant (5) contains an alternate 5' exon and initiates translation from an alternate start codon, compared to variant 1. The encoded protein (isoform 5) has a longer and distinct N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK150170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTGAAGG GAGGCAGGCC TGACCTCTGT GTGGTGAACT CTCTCATCGA GCTCCAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277655.1 |
CDS | 109..1968 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001290726.1 |
1 | ATGTTGAAGG GAGGCAGGCC TGACCTCTGT GTGGTGAACT CTCTCATCGA GCTCCAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16891 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290727.1 | |
Accession Version | NM_001290727.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1296bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | AT-rich interactive domain-containing protein 5A isoform 6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY196834.1, CX209955.1, AK149839.1 and AK029237.1. On Mar 19, 2014 this sequence version replaced XM_006495852.1. Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 6) has a shorter N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: CX209955.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCAAGG AGCTGAGGGG AGACGATGGG ACCACTGAGA AGCTGAAGAA GGCCAAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277656.1 |
CDS | 454..1749 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001290727.1 |
1 | ATGGCCAAGG AGCTGAGGGG AGACGATGGG ACCACTGAGA AGCTGAAGAA GGCCAAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14335 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290726.1 , XM_017319751.1 , XM_017319751.2 | |
Accession Version | XM_017319751.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | AT-rich interactive domain-containing protein 5A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGAAGG GAGGCAGGCC TGACCTCTGT GTGGTGAACT CTCTCATCGA GCTCCAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017175240.1 |
CDS | 279..2138 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017319751.1 |
1 | ATGTTGAAGG GAGGCAGGCC TGACCTCTGT GTGGTGAACT CTCTCATCGA GCTCCAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14335 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290726.1 , XM_017319751.1 , XM_017319751.2 | |
Accession Version | XM_017319751.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | AT-rich interactive domain-containing protein 5A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017319751.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGAAGG GAGGCAGGCC TGACCTCTGT GTGGTGAACT CTCTCATCGA GCTCCAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017175240.1 |
CDS | 4007..5866 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017319751.2 |
1 | ATGTTGAAGG GAGGCAGGCC TGACCTCTGT GTGGTGAACT CTCTCATCGA GCTCCAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a. |
Arid5a stabilizes OX40 mRNA in murine CD4 |
TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. |
Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury. |