Gene Symbol | Unc45b |
Entrez Gene ID | 217012 |
Full Name | unc-45 myosin chaperone B |
Synonyms | AA445617,Cmya4,D230041A13Rik,Unc45 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Unc45b cDNA ORF clone
Gene Symbol | Unc45b |
Entrez Gene ID | 217012 |
Full Name | unc-45 myosin chaperone B |
Synonyms | AA445617,Cmya4,D230041A13Rik,Unc45 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_178680.4 | NP_848795.3 | protein unc-45 homolog B |
Rattus norvegicus (Norway rat) | Unc45b | NP_001100498.1 |
Danio rerio (zebrafish) | unc45b | NP_705959.1 |
Drosophila melanogaster (fruit fly) | unc-45 | NP_524796.1 |
Pan troglodytes (chimpanzee) | UNC45B | XP_001174363.2 |
Mus musculus (house mouse) | Unc45b | NP_848795.3 |
Gallus gallus (chicken) | UNC45B | XP_004946569.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003727 | XP_310258.5 |
Canis lupus familiaris (dog) | UNC45B | XP_005624856.1 |
Bos taurus (cattle) | UNC45B | XP_002695676.1 |
Xenopus tropicalis (tropical clawed frog) | unc45b | NP_001172057.1 |
Homo sapiens (human) | UNC45B | NP_775259.1 |
UNC45B | XP_001113905.2 | |
Caenorhabditis elegans (roundworm) | unc-45 | NP_497205.1 |
Arid3b is essential for second heart field cell deployment and heart patterning.
Uribe V, Bad?a-Careaga C, Casanova JC, Dom?nguez JN, de la Pompa JL, Sanz-Ezquerro JJ
Development (Cambridge, England)141(21)4168-81(2014 Nov)
Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke.
Nicholls P, Bujalowski PJ, Epstein HF, Boehning DF, Barral JM, Oberhauser AF
FEBS letters588(21)3977-81(2014 Nov)
Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking.
Bird JE, Takagi Y, Billington N, Strub MP, Sellers JR, Friedman TB
Proceedings of the National Academy of Sciences of the United States of America111(34)12390-5(2014 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
UNC-45B and Hsp90 involved in sarcomere function
Title: Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke.
vertebrate Unc45 isoforms clearly demonstrates a direct role for Unc45 in Hsp90-mediated myosin motor domain folding and highlights major differences between the isoforms in substrate specificity and mechanism
Title: Unc45 activates Hsp90-dependent folding of the myosin motor domain.
mammalian Unc45b is a cytosolic protein that forms a stable complex with Hsp90, selectively binds the unfolded conformation of the myosin motor domain, and promotes motor domain folding
Title: Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain.
The following Unc45b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Unc45b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu07548 | |
Clone ID Related Accession (Same CDS sequence) | NM_178680.4 | |
Accession Version | NM_178680.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2790bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-21 | |
Organism | Mus musculus(house mouse) | |
Product | protein unc-45 homolog B | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY133112.1, AK084418.1 and BC084585.1. On Nov 10, 2009 this sequence version replaced NM_178680.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC084585.1, AK052294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAGAGG CTGAAGCGGC ACAGCTGAAG GAGGAGGGGA ACCGGCATTT TCAGCTCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_848795.3 |
CDS | 108..2897 |
Translation |
Target ORF information:
Target ORF information:
|
NM_178680.4 |
1 | ATGGCAGAGG CTGAAGCGGC ACAGCTGAAG GAGGAGGGGA ACCGGCATTT TCAGCTCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Arid3b is essential for second heart field cell deployment and heart patterning. |
Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke. |
Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking. |