Gene Symbol | Xylt2 |
Entrez Gene ID | 217119 |
Full Name | xylosyltransferase II |
Synonyms | E030002B02Rik,XT-II,XT2,xylT-II |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Xylt2 cDNA ORF clone
Gene Symbol | Xylt2 |
Entrez Gene ID | 217119 |
Full Name | xylosyltransferase II |
Synonyms | E030002B02Rik,XT-II,XT2,xylT-II |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017314478.1 | XP_017169967.1 | xylosyltransferase 2 isoform X1 |
XM_017314479.1 | XP_017169968.1 | xylosyltransferase 2 isoform X2 |
NM_145828.3 | NP_665827.2 | xylosyltransferase 2 |
Mus musculus (house mouse) | Xylt2 | NP_665827.2 |
Pan troglodytes (chimpanzee) | XYLT2 | NP_001009086.1 |
Bos taurus (cattle) | XYLT2 | NP_001008667.1 |
Xenopus tropicalis (tropical clawed frog) | xylt2 | NP_001006733.1 |
Rattus norvegicus (Norway rat) | Xylt2 | NP_071632.2 |
Gallus gallus (chicken) | XYLT2 | NP_001001785.1 |
XYLT2 | XP_001093519.1 | |
Homo sapiens (human) | XYLT2 | NP_071450.2 |
Canis lupus familiaris (dog) | XYLT2 | NP_001008714.1 |
Danio rerio (zebrafish) | zgc:194562 | NP_001124250.1 |
Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.
Munns CF, Fahiminiya S, Poudel N, Munteanu MC, Majewski J, Sillence DO, Metcalf JP, Biggin A, Glorieux F, Fassier F, Rauch F, Hinsdale ME
American journal of human genetics96(6)971-8(2015 Jun)
Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum.
Condac E, Dale GL, Bender-Neal D, Ferencz B, Towner R, Hinsdale ME
Glycobiology19(8)829-33(2009 Aug)
Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis.
Condac E, Silasi-Mansat R, Kosanke S, Schoeb T, Towner R, Lupu F, Cummings RD, Hinsdale ME
Proceedings of the National Academy of Sciences of the United States of America104(22)9416-21(2007 May)
Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance.
Wang M, Zhang Z, Zhang Z, Vikis H, Yan Y, Wang Y, You M
Cancer research67(6)2508-16(2007 Mar)
Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II.
Cuellar K, Chuong H, Hubbell SM, Hinsdale ME
The Journal of biological chemistry282(8)5195-200(2007 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the data from Xylt2 knock-out mice and mice with liver neoplasia show that liver is a significant source of serum XylT2 activity.
Title: Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum.
alterations in proteoglycans (PGs)concentrations can occur due to loss of XylT2, and that reduced PGs can induce cyst development
Title: Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis.
The following Xylt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xylt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu21302 | |
Clone ID Related Accession (Same CDS sequence) | NM_145828.3 | |
Accession Version | NM_145828.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2598bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-20 | |
Organism | Mus musculus(house mouse) | |
Product | xylosyltransferase 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK158056.1, AK150521.1 and AK083482.1. On Jan 18, 2008 this sequence version replaced NM_145828.2. ##Evidence-Data-START## Transcript exon combination :: AK083482.1, AK150521.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGTGGCGA GCGCGCGGGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATCGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_665827.2 |
CDS | 87..2684 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145828.3 |
1 | ATGGTGGCGA GCGCGCGGGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATCGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu77863 | |
Clone ID Related Accession (Same CDS sequence) | XM_017314478.1 | |
Accession Version | XM_017314478.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2052bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | xylosyltransferase 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGGCGA GCGCGCGGGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATCGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169967.1 |
CDS | 110..2161 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017314478.1 |
1 | ATGGTGGCGA GCGCGCGGGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATCGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu77864 | |
Clone ID Related Accession (Same CDS sequence) | XM_017314479.1 | |
Accession Version | XM_017314479.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2031bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | xylosyltransferase 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGGCGA GCGCGCGGGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATCGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169968.1 |
CDS | 110..2140 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017314479.1 |
1 | ATGGTGGCGA GCGCGCGGGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATCGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects. |
Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum. |
Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. |
Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. |
Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II. |