Gene Symbol | THRSP |
Entrez Gene ID | 21835 |
Full Name | thyroid hormone responsive |
Synonyms | S14,SPOT14 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
ORF » Species Summary » Mus musculus » THRSP cDNA ORF clone
Gene Symbol | THRSP |
Entrez Gene ID | 21835 |
Full Name | thyroid hormone responsive |
Synonyms | S14,SPOT14 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_009381.3 | NP_033407.1 | thyroid hormone-inducible hepatic protein |
NM_009381.2 | NP_033407.1 | thyroid hormone-inducible hepatic protein |
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.
Suresh S, Durakoglugil D, Zhou X, Zhu B, Comerford SA, Xing C, Xie XJ, York B, O'Donnell KA
PLoS genetics13(3)e1006650(2017 Mar)
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Fonseca TL, Fernandes GW, McAninch EA, Bocco BM, Abdalla SM, Ribeiro MO, Moh?csik P, Fekete C, Li D, Xing X, Wang T, Gereben B, Bianco AC
Proceedings of the National Academy of Sciences of the United States of America112(45)14018-23(2015 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
S14 has a potential role in regulating mammary tumor growth and fatty acid synthesis in vivo. Modulating the amount of medium chain fatty acids, by changing the levels of S14, has the potential to impact malignant mammary tumor phenotypes.
Title: Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis.
Data indicate SPOT14 as a potent marker for adult NSPCs that react dynamically to positive and negative neurogenic regulators.
Title: SPOT14-positive neural stem/progenitor cells in the hippocampus respond dynamically to neurogenic regulators.
These findings implicate Spot14 as a direct protein enhancer of FASN catalysis in the mammary gland during lactation when maximal MCFA production is needed.
Title: Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.
Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor alpha through a sterol regulatory element-binding protein 1c-dependent mechanism in mice.
Title: Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor ? through a sterol regulatory element-binding protein 1c-dependent mechanism in mice.
The structure of S14 suggests a mechanism whereby heterodimer formation with MIG12 attenuates the ability of MIG12 to activate ACC.
Title: Crystal structure of Spot 14, a modulator of fatty acid synthesis.
The following THRSP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THRSP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu04048 | |
Clone ID Related Accession (Same CDS sequence) | NM_009381.2 | |
Accession Version | NM_009381.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-14 | |
Organism | Mus musculus(House mouse) | |
Product | thyroid hormone-inducible hepatic protein | |
Comment |
1 | ATGCAAGTGC TAACGAAACG CTATCCCAAG AACTGCCTGC TGACAGTCAT GGATCGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033407.1 |
Translation |
Target ORF information:
Target ORF information:
|
NM_009381.2 |
1 | ATGCAAGTGC TAACGAAACG CTATCCCAAG AACTGCCTGC TGACAGTCAT GGATCGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu76899 | |
Clone ID Related Accession (Same CDS sequence) | NM_009381.3 | |
Accession Version | NM_009381.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-22 | |
Organism | Mus musculus(house mouse) | |
Product | thyroid hormone-inducible hepatic protein | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC172193.2, BY238050.1, AK077300.1 and AI117155.1. On Nov 25, 2015 this sequence version replaced NM_009381.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ266831.1, BC009165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAAGTGC TAACGAAACG CTATCCCAAG AACTGCCTGC TGACAGTCAT GGATCGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033407.1 |
CDS | 48..500 |
Translation |
Target ORF information:
Target ORF information:
|
NM_009381.3 |
1 | ATGCAAGTGC TAACGAAACG CTATCCCAAG AACTGCCTGC TGACAGTCAT GGATCGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. |
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. |