Gene Symbol | Rasa1 |
Entrez Gene ID | 218397 |
Full Name | RAS p21 protein activator 1 |
Synonyms | Gap,RasGAP,Rasa |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Rasa1 cDNA ORF clone
Gene Symbol | Rasa1 |
Entrez Gene ID | 218397 |
Full Name | RAS p21 protein activator 1 |
Synonyms | Gap,RasGAP,Rasa |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_011244518.2 | XP_011242820.1 | ras GTPase-activating protein 1 isoform X1 |
NM_145452.3 | NP_663427.2 | ras GTPase-activating protein 1 |
XM_011244518.3 | XP_011242820.1 | ras GTPase-activating protein 1 isoform X1 |
RASA1 | XP_001084074.2 | |
Xenopus tropicalis (tropical clawed frog) | LOC100135092 | NP_001107303.1 |
Pan troglodytes (chimpanzee) | RASA1 | XP_517663.3 |
Canis lupus familiaris (dog) | RASA1 | XP_536302.3 |
Bos taurus (cattle) | RASA1 | NP_776874.1 |
Mus musculus (house mouse) | Rasa1 | NP_663427.2 |
Rattus norvegicus (Norway rat) | Rasa1 | NP_037267.1 |
Gallus gallus (chicken) | RASA1 | XP_424907.4 |
Danio rerio (zebrafish) | rasa1a | XP_001342009.2 |
Drosophila melanogaster (fruit fly) | vap | NP_727926.2 |
Homo sapiens (human) | RASA1 | NP_002881.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002729 | XP_312197.3 |
RASA1 regulates the function of lymphatic vessel valves in mice.
Lapinski PE, Lubeck BA, Chen D, Doosti A, Zawieja SD, Davis MJ, King PD
The Journal of clinical investigation127(7)2569-2585(2017 Jun)
The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice.
Vanli G, Sempoux C, Widmann C
Molecular carcinogenesis56(6)1680-1684(2017 Jun)
The caspase-3-p120-RasGAP module generates a NF-?B repressor in response to cellular stress.
Khalil H, Loukili N, Regamey A, Cuesta-Marban A, Santori E, Huber M, Widmann C
Journal of cell science128(18)3502-13(2015 Sep)
Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.
Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD
Journal of immunology (Baltimore, Md. : 1950)195(1)31-5(2015 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
RASA1 catalytic activity is essential for the function and development of lymphatic vessel valves.
Title: RASA1 regulates the function of lymphatic vessel valves in mice.
These results indicate that the caspase-3/p120 RasGAP stress-sensing module impacts on carcinogen-induced liver cancer incidence but not sufficiently so as to affect overall survival.
Title: The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice.
Double-deficient RASA1-neurofibromin 1 mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 gene.
Title: Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.
Rasa1 may have a role in pathogenesis of capillary malformation-arteriovenous malformation in a mouse model
Title: Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation.
Regulation of Rasa1 translation by miR-132 was seen in severed axons, demonstrating local function within the axon.
Title: MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension.
The following Rasa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rasa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu73058 | |
Clone ID Related Accession (Same CDS sequence) | XM_011244518.2 , XM_011244518.3 | |
Accession Version | XM_011244518.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2676bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | ras GTPase-activating protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011244518.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGGCGG CCGAGGCGGG CAGTGAGGAA GGCGGCCCTG CGACGGCGGG CCCCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011242820.1 |
CDS | 366..3041 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011244518.3 |
1 | ATGATGGCGG CCGAGGCGGG CAGTGAGGAA GGCGGCCCTG CGACGGCGGG CCCCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13108 | |
Clone ID Related Accession (Same CDS sequence) | NM_145452.3 | |
Accession Version | NM_145452.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3117bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-26 | |
Organism | Mus musculus(house mouse) | |
Product | ras GTPase-activating protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB645489.1, BU055087.1, BC065082.1, CV555618.1 and CF534745.1. On Jan 12, 2008 this sequence version replaced NM_145452.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGATGGCGG CCGAGGCGGG CAGTGAGGAA GGCGGCCCTG CGACGGCGGG CCCCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_663427.2 |
CDS | 580..3696 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145452.3 |
1 | ATGATGGCGG CCGAGGCGGG CAGTGAGGAA GGCGGCCCTG CGACGGCGGG CCCCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu73058 | |
Clone ID Related Accession (Same CDS sequence) | XM_011244518.2 , XM_011244518.3 | |
Accession Version | XM_011244518.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2676bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | ras GTPase-activating protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011244518.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGGCGG CCGAGGCGGG CAGTGAGGAA GGCGGCCCTG CGACGGCGGG CCCCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011242820.1 |
CDS | 587..3262 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011244518.2 |
1 | ATGATGGCGG CCGAGGCGGG CAGTGAGGAA GGCGGCCCTG CGACGGCGGG CCCCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RASA1 regulates the function of lymphatic vessel valves in mice. |
The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice. |
The caspase-3-p120-RasGAP module generates a NF-?B repressor in response to cellular stress. |
Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. |