Tub cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Tub |
| Entrez Gene ID | 22141 |
| Full Name | tubby bipartite transcription factor |
| Synonyms | rd5,tub |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_021885.4 | NP_068685.1 | tubby protein |
| Canis lupus familiaris (dog) | TUB | XP_005633682.1 |
| Mus musculus (house mouse) | Tub | NP_068685.1 |
| Gallus gallus (chicken) | TUB | XP_420992.3 |
| Oryza sativa (rice) | Os03g0351400 | NP_001050117.1 |
| Xenopus tropicalis (tropical clawed frog) | tub | NP_001007493.1 |
| TUB | XP_002799697.1 | |
| Rattus norvegicus (Norway rat) | Tub | NP_037209.1 |
| Caenorhabditis elegans (roundworm) | tub-1 | NP_495710.1 |
| Homo sapiens (human) | TUB | NP_003311.2 |
| Pan troglodytes (chimpanzee) | TUB | XP_003312952.1 |
| Bos taurus (cattle) | TUB | NP_001179089.1 |
| Danio rerio (zebrafish) | tub | XP_005172409.1 |
Related articles in PubMed
Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)
C-terminally mutated tubby protein accumulates in aggresomes.
Kim S, Sung HJ, Lee JW, Kim YH, Oh YS, Yoon KA, Heo K, Suh PG
BMB reports50(1)37-42(2017 Jan)
Correlation of ER stress and retinal degeneration in tubby mice.
Cai X, Chen L, McGinnis JF
Experimental eye research140130-138(2015 Nov)
Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.
Loktev AV, Jackson PK
Cell reports5(5)1316-29(2013 Dec)
Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia.
Nakahara K, Bannai M, Maruyama K, Suzuki Y, Okame R, Murakami N
American journal of physiology. Endocrinology and metabolism305(3)E451-63(2013 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We found that the mutant Tub proteins were mostly localized to puncta found in the perinuclear region and that the C-terminus was important for its solubility. our results suggest that the malfunctions of the Tub mutant are caused by its misfolding and subsequent localization to aggresomes.
Title: C-terminally mutated tubby protein accumulates in aggresomes.
These results suggest that tubby is a ligand to facilitate microglial phagocytosis through MerTK for the maintenance of CNS homeostasis.
Title: Tubby regulates microglial phagocytosis through MerTK.
Mtap1a, which modifies hearing loss in Tub(tub/tub) mice, also modifies retinal degeneration in Tub and Tulp1 mice; functionally nonredundant members of the TULP family (TUB and TULP1) share a common functional interaction with MTAP1A
Title: An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice.
Tubby and Tulp1 function as phagocytosis sigmals (eat-me) for retinal pigment epithelium cells and other phagocytes.
Title: Identification of tubby and tubby-like protein 1 as eat-me signals by phage display.
TUB plays a role in insulin signalling and fuel homeostasis in adipocytes.
Title: Expression and modulation of TUB by insulin and thyroid hormone in primary rat and murine 3T3-L1 adipocytes.
The following Tub gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tub cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu22226 | |
| Clone ID Related Accession (Same CDS sequence) | NM_021885.4 | |
| Accession Version | NM_021885.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1518bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | tubby protein | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147700.1 and BC096554.1. On Dec 23, 2005 this sequence version replaced NM_021885.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147700.1, BC096554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGACTTCCA AGCCGCATTC CGACTGGATT CCTTACAGTG TCCTAGATGA TGAGGGCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_068685.1 |
| CDS | 222..1739 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_021885.4 |
ORF Insert Sequence:
1 | ATGACTTCCA AGCCGCATTC CGACTGGATT CCTTACAGTG TCCTAGATGA TGAGGGCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. |
|
C-terminally mutated tubby protein accumulates in aggresomes. |
|
Correlation of ER stress and retinal degeneration in tubby mice. |
|
Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia. |
|
Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia. |