Gene Symbol | Vasp |
Entrez Gene ID | 22323 |
Full Name | vasodilator-stimulated phosphoprotein |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Vasp cDNA ORF clone
gRNAs
Gene Symbol | Vasp |
Entrez Gene ID | 22323 |
Full Name | vasodilator-stimulated phosphoprotein |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_009499.3 | NP_033525.2 | vasodilator-stimulated phosphoprotein isoform 1 |
NM_001282022.1 | NP_001268951.1 | vasodilator-stimulated phosphoprotein isoform 3 |
NM_001282021.1 | NP_001268950.1 | vasodilator-stimulated phosphoprotein isoform 2 |
Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning.
K?hler D, Bibli SI, Klammer LP, Roth JM, Lehmann R, Fleming I, Granja TF, Straub A, Benz PM, Rosenberger P
Basic research in cardiology113(2)11(2018 Jan)
A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons.
Vidaki M, Drees F, Saxena T, Lanslots E, Taliaferro MJ, Tatarakis A, Burge CB, Wang ET, Gertler FB
Neuron95(3)608-622.e5(2017 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We identified a phosphorylation-dependent mechanism that regulates selective recruitment of these effectors to Lamellipodin: Abl-mediated Lamellipodin phosphorylation promotes its association with both Scar/WAVE and Ena/VASP, whereas Src-dependent phosphorylation enhances binding to Scar/WAVE but not to Ena/VASP
Title: Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.
Thus, unlike host proteins characterized in Shigella pathogenesis that promote bacterial spread, VASP and EVL function to limit it.
Title: Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery.
Low VASP activation was associated with high fat diet (HFD). Effects of HFD on aortic inflammation and insulin resistance were recapitulated by VASP knockout, implying a role for VASP to constrain inflammatory signaling and maintain insulin sensitivity.
Title: Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance.
Ena/VASP regulates mDia2-initiated filopodial morphology, dynamics, and function.
Title: Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function.
Data show that the hypoxia inducible factor 1 alpha subunit (HIF-1alpha) protein level in lung tissues increased significantly at four hours and eight hours, whereas the vasodilator-stimulated phosphoprotein (VASP) protein level decreased significantly.
Title: TNF-? mediated increase of HIF-1? inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).
The following Vasp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vasp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13737 | |
Clone ID Related Accession (Same CDS sequence) | NM_001282021.1 | |
Accession Version | NM_001282021.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | vasodilator-stimulated phosphoprotein isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB850928.1, AK140329.1 and CO040918.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK157021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGCGAGA CGGTCATCTG TTCCAGCCGG GCTACTGTGA TGCTTTATGA TGACAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001268950.1 |
CDS | 337..1461 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCGAGA CGGTCATCTG TTCCAGCCGG GCTACTGTGA TGCTTTATGA TGACAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13740 | |
Clone ID Related Accession (Same CDS sequence) | NM_001282022.1 | |
Accession Version | NM_001282022.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | vasodilator-stimulated phosphoprotein isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB850928.1, AK140329.1 and CO040918.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK170780.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGCGAGA CGGTCATCTG TTCCAGCCGG GCTACTGTGA TGCTTTATGA TGACAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001268951.1 |
CDS | 337..1434 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCGAGA CGGTCATCTG TTCCAGCCGG GCTACTGTGA TGCTTTATGA TGACAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13703 | |
Clone ID Related Accession (Same CDS sequence) | NM_009499.3 | |
Accession Version | NM_009499.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Mus musculus(house mouse) | |
Product | vasodilator-stimulated phosphoprotein isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB850928.1, AK140329.1 and CO040918.1. On Aug 14, 2013 this sequence version replaced NM_009499.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010223.1, AK140329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGCGAGA CGGTCATCTG TTCCAGCCGG GCTACTGTGA TGCTTTATGA TGACAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033525.2 |
CDS | 337..1464 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCGAGA CGGTCATCTG TTCCAGCCGG GCTACTGTGA TGCTTTATGA TGACAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning. |
A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons. |