Gene Symbol | Vps33b |
Entrez Gene ID | 233405 |
Full Name | vacuolar protein sorting 33B |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Vps33b cDNA ORF clone
gRNAs
Gene Symbol | Vps33b |
Entrez Gene ID | 233405 |
Full Name | vacuolar protein sorting 33B |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_178070.4 | NP_835171.2 | vacuolar protein sorting-associated protein 33B |
XM_017322173.1 | XP_017177662.1 | vacuolar protein sorting-associated protein 33B isoform X1 |
XM_030242473.1 | XP_030098333.1 | vacuolar protein sorting-associated protein 33B isoform X1 |
Pan troglodytes (chimpanzee) | VPS33B | XP_510601.2 |
Mus musculus (house mouse) | Vps33b | NP_835171.2 |
Caenorhabditis elegans (roundworm) | vps-33.2 | NP_495342.2 |
Canis lupus familiaris (dog) | VPS33B | XP_536197.2 |
Danio rerio (zebrafish) | vps33b | NP_001014370.1 |
VPS33B | XP_001097946.1 | |
Gallus gallus (chicken) | VPS33B | NP_001026519.1 |
Bos taurus (cattle) | VPS33B | NP_001039749.1 |
Homo sapiens (human) | VPS33B | NP_061138.3 |
Rattus norvegicus (Norway rat) | Vps33b | NP_071622.1 |
Xenopus tropicalis (tropical clawed frog) | vps33b | NP_001096504.1 |
Vps33b is crucial for structural and functional hepatocyte polarity.
Hanley J, Dhar DK, Mazzacuva F, Fiadeiro R, Burden JJ, Lyne AM, Smith H, Straatman-Iwanowska A, Banushi B, Virasami A, Mills K, Lemaigre FP, Knisely AS, Howe S, Sebire N, Waddington SN, Paulusma CC, Clayton P, Gissen P
Journal of hepatology66(5)1001-1011(2017 05)
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, Shao H, Zeng H, Yu Z, Xie L, Xia F, Zhang F, Liu X, Zhang Y, Jiang H, Zhu J, Wan J, Wang C, Weng W, Xie J, Tao M, Zhang CC, Liu J, Chen GQ, Zheng J
The Journal of clinical investigation126(12)4537-4553(2016 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
VPS33B is vital for maintenance of mammalian structural and functional hepatocyte polarity.
Title: Vps33b is crucial for structural and functional hepatocyte polarity.
VPS33B interacted with the GDI2/RAB11A/RAB27A pathway to regulate the trafficking of secretory proteins as exosomes.
Title: Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The data presented in this study suggest that Vps33b is involved in alpha-granule formation possibly by facilitating the Vwf-positive vesicular trafficking to alpha-granule-related vacuoles in megakaryocytes.
Title: Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes.
this study shows that Vps33B is required in mouse macrophages for normal maturation of phagosomes and specialized endosomes that are induced upon pattern-recognition receptors activation
Title: ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination.
Abnormal protein trafficking and impairment in multivesicular bodies maturation in Megakaryocytes underlie the alpha-granule deficiency in Vps33b(fl/fl)-ER(T2) mouse and ARC patients.
Title: VPS33B regulates protein sorting into and maturation of ?-granule progenitor organelles in mouse megakaryocytes.
The following Vps33b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vps33b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu07060 | |
Clone ID Related Accession (Same CDS sequence) | NM_178070.4 | |
Accession Version | NM_178070.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-03 | |
Organism | Mus musculus(house mouse) | |
Product | vacuolar protein sorting-associated protein 33B | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK032076.1, CD560991.1, AU257277.1 and BC028783.1. On Oct 31, 2007 this sequence version replaced NM_178070.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK032076.1, BC034170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTTTTC CCCATCGGCT GGACGCCCCT GAGCTTCCCG ACTTCTCTAT GCTCAAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_835171.2 |
CDS | 330..2183 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGCTTTTC CCCATCGGCT GGACGCCCCT GAGCTTCCCG ACTTCTCTAT GCTCAAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu82045 | |
Clone ID Related Accession (Same CDS sequence) | XM_017322173.1 | |
Accession Version | XM_017322173.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | vacuolar protein sorting-associated protein 33B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTTTTC CCCATCGGCT GGACGCCCCT GAGCTTCCCG ACTTCTCTAT GCTCAAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017177662.1 |
CDS | 353..1531 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTTTTC CCCATCGGCT GGACGCCCCT GAGCTTCCCG ACTTCTCTAT GCTCAAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu89448 | |
Clone ID Related Accession (Same CDS sequence) | XM_030242473.1 | |
Accession Version | XM_030242473.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | vacuolar protein sorting-associated protein 33B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTTTTC CCCATCGGCT GGACGCCCCT GAGCTTCCCG ACTTCTCTAT GCTCAAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030098333.1 |
CDS | 364..1596 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTTTTC CCCATCGGCT GGACGCCCCT GAGCTTCCCG ACTTCTCTAT GCTCAAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Vps33b is crucial for structural and functional hepatocyte polarity. |
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. |