Gene Symbol | Setd1a |
Entrez Gene ID | 233904 |
Full Name | SET domain containing 1A |
Synonyms | BC010250,KMT2F,Nsccn1,mKIAA0339,mNSC1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Setd1a cDNA ORF clone
Gene Symbol | Setd1a |
Entrez Gene ID | 233904 |
Full Name | SET domain containing 1A |
Synonyms | BC010250,KMT2F,Nsccn1,mKIAA0339,mNSC1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017322211.1 | XP_017177700.1 | histone-lysine N-methyltransferase SETD1A isoform X1 |
XM_017322212.1 | XP_017177701.1 | histone-lysine N-methyltransferase SETD1A isoform X1 |
XM_017322214.1 | XP_017177703.1 | histone-lysine N-methyltransferase SETD1A isoform X1 |
NM_178029.3 | NP_821172.2 | histone-lysine N-methyltransferase SETD1A |
XM_017322213.1 | XP_017177702.1 | histone-lysine N-methyltransferase SETD1A isoform X1 |
SETD1A protects HSCs from activation-induced functional decline in vivo.
Arndt K, Kranz A, Fohgrub J, Jolly A, Bledau AS, Di Virgilio M, Lesche M, Dahl A, H?fer T, Stewart AF, Waskow C
Blood(2018 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
a critical role for Set1A catalytic methyltransferase activity in regulating ESC differentiation
Title: Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation.
SET1A/COMPASS is required for full transcriptional activation of multiple Hox genes but functions independently of the E1 and E2 cis-regulatory elements
Title: SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression.
miR-29a mimic transfection lowered collagen 1alpha1, DNMT1, DNMT3b and SET1A expression in hepatic stellate cells.
Title: MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases.
data indicate that Setd1a and NURF complexes are specifically targeted to and coordinately regulate erythroid promoter chromatin dynamics during erythroid lineage differentiation
Title: Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.
our study provides valuable information on the molecular interactions between OSKM(Oct4, Sox2, Klf4, and Myc) and cofactors and molecular mechanisms for the functional importance of Set1a in ESCs and early development
Title: H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass.
The following Setd1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Setd1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19337 | |
Clone ID Related Accession (Same CDS sequence) | XM_017322211.1 , XM_017322212.1 , XM_017322214.1 , NM_178029.3 , XM_017322213.1 | |
Accession Version | NM_178029.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5151bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | histone-lysine N-methyltransferase SETD1A | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149222.4. On or before Dec 17, 2006 this sequence version replaced XM_894035.2, XM_994371.1, XM_985966.1, NM_178029.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_821172.2 |
CDS | 141..5291 |
Translation |
Target ORF information:
Target ORF information:
|
NM_178029.3 |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19337 | |
Clone ID Related Accession (Same CDS sequence) | XM_017322211.1 , XM_017322212.1 , XM_017322214.1 , NM_178029.3 , XM_017322213.1 | |
Accession Version | XM_017322211.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5151bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | histone-lysine N-methyltransferase SETD1A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017177700.1 |
CDS | 1260..6410 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017322211.1 |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19337 | |
Clone ID Related Accession (Same CDS sequence) | XM_017322211.1 , XM_017322212.1 , XM_017322214.1 , NM_178029.3 , XM_017322213.1 | |
Accession Version | XM_017322212.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5151bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | histone-lysine N-methyltransferase SETD1A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017177701.1 |
CDS | 187..5337 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017322212.1 |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19337 | |
Clone ID Related Accession (Same CDS sequence) | XM_017322211.1 , XM_017322212.1 , XM_017322214.1 , NM_178029.3 , XM_017322213.1 | |
Accession Version | XM_017322214.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5151bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | histone-lysine N-methyltransferase SETD1A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017177703.1 |
CDS | 383..5533 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017322214.1 |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19337 | |
Clone ID Related Accession (Same CDS sequence) | XM_017322211.1 , XM_017322212.1 , XM_017322214.1 , NM_178029.3 , XM_017322213.1 | |
Accession Version | XM_017322213.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5151bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | histone-lysine N-methyltransferase SETD1A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017177702.1 |
CDS | 44..5194 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017322213.1 |
1 | ATGGACCAGG AAGGTGGGGG AGACGGGCAG AAAGCCCCGA GCTTCCAGTG GCGGAACTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
SETD1A protects HSCs from activation-induced functional decline in vivo. |