Ccnb1ip1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccnb1ip1
Entrez Gene ID	239083
Full Name	cyclin B1 interacting protein 1
Synonyms	Gm288,Hei10,mei4
General protein information	Preferred Names cyclin B1 interacting protein 1 Names E3 ubiquitin-protein ligase CCNB1IP1 RING-type E3 ubiquitin transferase CCNB1IP1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001111119.1	NP_001104589.1	E3 ubiquitin-protein ligase CCNB1IP1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ccnb1ip1	NP_001104589.1
Danio rerio (zebrafish)	LOC562825	XP_691290.3
	CCNB1IP1	XP_002805009.1
Homo sapiens (human)	CCNB1IP1	NP_067001.3
Canis lupus familiaris (dog)	CCNB1IP1	XP_539671.3
Rattus norvegicus (Norway rat)	Ccnb1ip1	NP_001020312.1
Xenopus tropicalis (tropical clawed frog)	LOC100489156	XP_002934367.2
Pan troglodytes (chimpanzee)	CCNB1IP1	XP_001142928.2
Bos taurus (cattle)	CCNB1IP1	NP_001040030.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island.
Wang RJ, Payseur BA
Genetics206(4)1841-1852(2017 08)

A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination.
Rao HB, Qiao H, Bhatt SK, Bailey LR, Tran HD, Bourne SL, Qiu W, Deshpande A, Sharma AN, Beebout CJ, Pezza RJ, Hunter N
Science (New York, N.Y.)355(6323)403-407(2017 01)

An insulator element located at the cyclin B1 interacting protein 1 gene locus is highly conserved among mammalian species.
Yoshida W, Tomikawa J, Inaki M, Kimura H, Onodera M, Hata K, Nakabayashi K
PloS one10(6)e0131204(2015)

Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
Holloway JK, Sun X, Yokoo R, Villeneuve AM, Cohen PE
The Journal of cell biology205(5)633-41(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interdependent localization of SUMO, ubiquitin, and proteasomes along chromosome axes was mediated largely by RNF212 and HEI10, two E3 ligases that are also essential for crossover recombination.
Title: A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination.

Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Title: Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.

Mei4 and Rec114, are evolutionarily conserved in most eukaryotes and Mei4(-/-) mice are deficient in meiotic DSB formation, thus showing the functional conservation of Mei4 in mice
Title: Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice.

Cloning and characterization of the mei4 ortholog of Hei10 (also known as Gm288 in mouse) demonstrates a novel link between cell cycle regulation and mismatch repair during prophase I.
Title: Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.

The following Ccnb1ip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccnb1ip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16162	NM_001111119.1 Latest version!	Mus musculus cyclin B1 interacting protein 1 (Ccnb1ip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccnb1ip1 ( NM_001111119.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001104589.1 Mus musculus cyclin B1 interacting protein 1 (Ccnb1ip1), mRNA.

Price & Availability↑

CloneID	OMu16162
Clone ID Related Accession (Same CDS sequence)	NM_001111119.1
Accession Version	NM_001111119.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase CCNB1IP1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC027184.15. On Dec 11, 2007 this sequence version replaced XM_139038.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGTCTTTGT GTGAAGACAT GCTGCTTTGC AATTATCGGA AGTGTCGGAT CAAGCTCTCT 
GGTTATGCTT GGGTCACTGC CTGTTCTCAC ATCTTCTGCG ATCAGCACGG CAGCGGGGAG 
TTCAGTCGTT CACCAGCGAT CTGTCCTGCT TGCAACAGTA CCCTTTCTGG AAAGCTAGAT 
ATTGTTCGAA CAGAACTCAG TCCATCAGAG GAGTACAAAG CTATGGTATT GGCAGGGCTT 
CGCCCAGAGG TTGTTTTGGA CATTAGCTCC CGGGCATTGG CCTTCTGGAC ATACCAGGTA 
CACCAGGAGC GTCTCTATCA AGAGTATAAT TTCAGCAAGG CCGAGAACCA CTTAAAACAG 
ATGGAGAAGA TGTATATGCA GCAAATACAG AGCAAGAATA TAGAATTGAC CTCTATGAAA 
GGGGAGGTTA TTTCCATGAA GAAAGTTCTA GAAGAATACA AGAAAAAGTT TAGTGACATC 
TCTGAAAAAC TTATGGAGCG TAATCGCCAG TACCAAAAGC TCCAAGGCCT TTATGATAGC 
CTTAGGCTAA GAAATATCAC TATCGCCAGC CAAGAAGGCT CCCTGGAACC AGGTATGATC 
CCGCAGTCTG GAGTCTTTGG CTTCCCACCA GGGAATAACT CAAAGTTTTC TTTGGACCAT 
ATACCAGTTG GAAATCAAGG TGGTGGAGAT GAAGATGTTC AGTTCAGACC ATTTTTTGTG 
TGTTCTCCCA CAGCGCCTGA ACCCATTAAC AACTTCTTTA GTTTTGCATC TCCAAGCCAT 
GAAGCAGAGC AGCAAGTCTG CAGCAGGGCC TTTAAAGCAA AAAGAATTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104589.1
CDS	114..944
Translation	MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLDIVRTELSPSEEYKAMVLAGLRPEVVLDISSRALAFWTYQVHQERLYQEYNFSKAENHLKQMEKMYMQQIQSKNIELTSMKGEVISMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIASQEGSLEPGMIPQSGVFGFPPGNNSKFSLDHIPVGNQGGGDEDVQFRPFFVCSPTAPEPINNFFSFASPSHEAEQQVCSRAFKAKRI

Target ORF information:

RefSeq Version	NM_001111119.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin B1 interacting protein 1 (Ccnb1ip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001111119.1

ORF Insert Sequence:

ATGTCTTTGT GTGAAGACAT GCTGCTTTGC AATTATCGGA AGTGTCGGAT CAAGCTCTCT 
GGTTATGCTT GGGTCACTGC CTGTTCTCAC ATCTTCTGCG ATCAGCACGG CAGCGGGGAG 
TTCAGTCGTT CACCAGCGAT CTGTCCTGCT TGCAACAGTA CCCTTTCTGG AAAGCTAGAT 
ATTGTTCGAA CAGAACTCAG TCCATCAGAG GAGTACAAAG CTATGGTATT GGCAGGGCTT 
CGCCCAGAGG TTGTTTTGGA CATTAGCTCC CGGGCATTGG CCTTCTGGAC ATACCAGGTA 
CACCAGGAGC GTCTCTATCA AGAGTATAAT TTCAGCAAGG CCGAGAACCA CTTAAAACAG 
ATGGAGAAGA TGTATATGCA GCAAATACAG AGCAAGAATA TAGAATTGAC CTCTATGAAA 
GGGGAGGTTA TTTCCATGAA GAAAGTTCTA GAAGAATACA AGAAAAAGTT TAGTGACATC 
TCTGAAAAAC TTATGGAGCG TAATCGCCAG TACCAAAAGC TCCAAGGCCT TTATGATAGC 
CTTAGGCTAA GAAATATCAC TATCGCCAGC CAAGAAGGCT CCCTGGAACC AGGTATGATC 
CCGCAGTCTG GAGTCTTTGG CTTCCCACCA GGGAATAACT CAAAGTTTTC TTTGGACCAT 
ATACCAGTTG GAAATCAAGG TGGTGGAGAT GAAGATGTTC AGTTCAGACC ATTTTTTGTG 
TGTTCTCCCA CAGCGCCTGA ACCCATTAAC AACTTCTTTA GTTTTGCATC TCCAAGCCAT 
GAAGCAGAGC AGCAAGTCTG CAGCAGGGCC TTTAAAGCAA AAAGAATTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island.
Genetics206(4)1841-1852(2017 08)
Wang RJ,Payseur BA

A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination.
Science (New York, N.Y.)355(6323)403-407(2017 01)
Rao HB,Qiao H,Bhatt SK,Bailey LR,Tran HD,Bourne SL,Qiu W,Deshpande A,Sharma AN,Beebout CJ,Pezza RJ,Hunter N

An insulator element located at the cyclin B1 interacting protein 1 gene locus is highly conserved among mammalian species.
PloS one10(6)e0131204(2015)
Yoshida W,Tomikawa J,Inaki M,Kimura H,Onodera M,Hata K,Nakabayashi K

Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
The Journal of cell biology205(5)633-41(2014 Jun)
Holloway JK,Sun X,Yokoo R,Villeneuve AM,Cohen PE