Best1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Best1 |
| Entrez Gene ID | 24115 |
| Full Name | bestrophin 1 |
| Synonyms | Bmd,Vmd2,mBest1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_011247250.1 | XP_011245552.1 | bestrophin-1 isoform X1 |
| NM_011913.2 | NP_036043.2 | bestrophin-1 |
| Homo sapiens (human) | BEST1 | NP_004174.1 |
| Bos taurus (cattle) | BEST1 | NP_001073714.1 |
| Mus musculus (house mouse) | Best1 | NP_036043.2 |
| Danio rerio (zebrafish) | LOC560608 | XP_689098.3 |
| Pan troglodytes (chimpanzee) | BEST1 | XP_001151529.1 |
| LOC718993 | XP_001116591.1 | |
| Xenopus tropicalis (tropical clawed frog) | best1 | NP_001155223.1 |
| Canis lupus familiaris (dog) | BEST1 | NP_001091014.1 |
| Rattus norvegicus (Norway rat) | Best1 | NP_001011940.1 |
| Gallus gallus (chicken) | BEST1 | XP_004941545.1 |
Related articles in PubMed
Direct interaction with 14-3-3? promotes surface expression of Best1 channel in astrocyte.
Oh SJ, Woo J, Lee YS, Cho M, Kim E, Cho NC, Park JY, Pae AN, Justin Lee C, Hwang EM
Molecular brain10(1)51(2017 Nov)
Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: MaxiK, Cav1.3 and Bestrophin-1.
Strau? O, Reichhart N, Gomez NM, M?ller C
Advances in experimental medicine and biology854739-44(2016)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that the ion channels CaV1.3, bestrophin-1 and maxiK were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE).
Title: Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: MaxiK, Cav1.3 and Bestrophin-1.
Best1-mediated astrocytic glutamate activates the synaptic N-methyl-D-aspartate receptor (NMDAR) and modulates NMDAR-dependent synaptic plasticity.
Title: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
Bestrophin-1 functions as an intracellular Cl channel which helps to accumulate and to release Ca(2+) from stores by conducting the counterion for Ca(2+).
Title: The role of bestrophin-1 in intracellular Ca(2+) signaling.
Best1, located at the microdomains near the synaptic junctions, has a significantly high permeability to glutamate in vivo.
Title: High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte.
Results show that different mutations in Best1 cause differential effects on its localization and that this effect varies with the presence or absence of wild-type (WT) Best1.
Title: Differential effects of Best disease causing missense mutations on bestrophin-1 trafficking.
The following Best1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Best1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu21134 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011247250.1 , NM_011913.2 | |
| Accession Version | NM_011913.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-26 | |
| Organism | Mus musculus(house mouse) | |
| Product | bestrophin-1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY105692.1, BY714344.1, AY450427.1, AK006549.1 and BX634624.1. On Nov 15, 2007 this sequence version replaced NM_011913.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AY450427.1, BC139060.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGACTATCA CCTACACAAA CAAAGTAGCC AATGCCCGCC TCGGTTCGTT CTCGTCCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_036043.2 |
| CDS | 213..1868 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_011913.2 |
ORF Insert Sequence:
1 | ATGACTATCA CCTACACAAA CAAAGTAGCC AATGCCCGCC TCGGTTCGTT CTCGTCCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu21134 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011247250.1 , NM_011913.2 | |
| Accession Version | XM_011247250.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-02-08 | |
| Organism | Mus musculus(House mouse) | |
| Product | bestrophin-1 isoform X1 | |
| Comment | ||
1 | ATGACTATCA CCTACACAAA CAAAGTAGCC AATGCCCGCC TCGGTTCGTT CTCGTCCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011245552.1 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011247250.1 |
ORF Insert Sequence:
1 | ATGACTATCA CCTACACAAA CAAAGTAGCC AATGCCCGCC TCGGTTCGTT CTCGTCCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Direct interaction with 14-3-3? promotes surface expression of Best1 channel in astrocyte. |
|
Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: MaxiK, Cav1.3 and Bestrophin-1. |