Gene Symbol | Auts2 |
Entrez Gene ID | 319974 |
Full Name | autism susceptibility candidate 2 |
Synonyms | 2700063G02Rik,A730011F23Rik,D830032G16Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Auts2 cDNA ORF clone
Gene Symbol | Auts2 |
Entrez Gene ID | 319974 |
Full Name | autism susceptibility candidate 2 |
Synonyms | 2700063G02Rik,A730011F23Rik,D830032G16Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001363480.1 | NP_001350409.1 | autism susceptibility gene 2 protein homolog |
NM_177047.3 | NP_796021.2 | autism susceptibility gene 2 protein homolog |
AUTS2 | XP_001089340.2 | |
Mus musculus (house mouse) | Auts2 | NP_796021.2 |
Danio rerio (zebrafish) | auts2 | XP_002663599.2 |
Homo sapiens (human) | AUTS2 | NP_056385.1 |
Pan troglodytes (chimpanzee) | AUTS2 | XP_519135.3 |
Canis lupus familiaris (dog) | AUTS2 | XP_536837.3 |
Rattus norvegicus (Norway rat) | LOC100362819 | XP_002728006.2 |
Gallus gallus (chicken) | AUTS2 | XP_415729.2 |
Xenopus tropicalis (tropical clawed frog) | auts2 | XP_002935848.2 |
TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.
Chen CY, Liu HY, Hsueh YP
EMBO reports18(1)169-183(2017 01)
AUTS2 in the nucleus accumbens is essential for heroin-induced behavioral sensitization.
Zhu Y, Xing B, Dang W, Ji Y, Yan P, Li Y, Qiao X, Lai J
Neuroscience33335-43(2016 Oct)
Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory.
Hori K, Nagai T, Shan W, Sakamoto A, Abe M, Yamazaki M, Sakimura K, Yamada K, Hoshino M
PloS one10(12)e0145979(2015)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Study reveals AUTS2 signaling role in mediating heroin-induced behavioral and neurochemical adaptations in the nucleus accumbens, but not the caudate-putamen, potentially mediated through the control of Rac1 activity.
Title: AUTS2 in the nucleus accumbens is essential for heroin-induced behavioral sensitization.
AUTS2 activates Rac1 to induce lamellipodia but downregulates Cdc42 to suppress filopodia.
Title: Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.
Our results implicate Auts2 as an active regulator of important neurodevelopmental genes and pathways and identify novel genomic regions that could be associated with ASD and other neurodevelopmental diseases.
Title: Genome-wide distribution of Auts2 binding localizes with active neurodevelopmental genes.
Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology.
Title: Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology.
The following Auts2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Auts2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu05876 | |
Clone ID Related Accession (Same CDS sequence) | NM_001363480.1 , NM_177047.3 | |
Accession Version | NM_001363480.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3786bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Mus musculus(house mouse) | |
Product | autism susceptibility gene 2 protein homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB658109.1, BB621504.1, AK052418.1, BC096021.1, BC058110.1, AK147478.1 and CV557700.1. On May 24, 2018 this sequence version replaced NM_177047.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147478.1, BC096021.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGGCC CGACGCGGGG ACATGGACTC CGGAAAAAGC GGAGGTCTCG ATCACAGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001350409.1 |
CDS | 1398..5183 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001363480.1 |
1 | ATGGATGGCC CGACGCGGGG ACATGGACTC CGGAAAAAGC GGAGGTCTCG ATCACAGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu05876 | |
Clone ID Related Accession (Same CDS sequence) | NM_001363480.1 , NM_177047.3 | |
Accession Version | NM_177047.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3786bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | autism susceptibility gene 2 protein homolog | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC096021.1, AK052418.1, BC058110.1 and CA320283.1. On or before Feb 6, 2007 this sequence version replaced NM_001024852.1, NM_177047.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096021.1, AK147478.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGGCC CGACGCGGGG ACATGGACTC CGGAAAAAGC GGAGGTCTCG ATCACAGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_796021.2 |
CDS | 521..4306 |
Translation |
Target ORF information:
Target ORF information:
|
NM_177047.3 |
1 | ATGGATGGCC CGACGCGGGG ACATGGACTC CGGAAAAAGC GGAGGTCTCG ATCACAGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology. |
AUTS2 in the nucleus accumbens is essential for heroin-induced behavioral sensitization. |
Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory. |