Jph4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Jph4
Entrez Gene ID	319984
Full Name	junctophilin 4
Synonyms	9330157P13Rik,JP-4,JPHL1
General protein information	Preferred Names junctophilin 4 Names junctophilin-4 junctophilin-like 1 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 C3

mRNA and Protein(s)

mRNA Protein Name

NM_177049.5 NP_796023.2 junctophilin-4
Pathways from BioSystems

mRNA	Protein	Name
NM_177049.5	NP_796023.2	junctophilin-4

Homologies

Rattus norvegicus (Norway rat)	Jph4	NP_001003711.1
Xenopus tropicalis (tropical clawed frog)	LOC100490043	XP_002941565.1
	JPH4	XP_001109282.1
Homo sapiens (human)	JPH4	NP_001139500.1
Canis lupus familiaris (dog)	JPH4	XP_547737.3
Bos taurus (cattle)	JPH4	NP_001192339.1
Mus musculus (house mouse)	Jph4	NP_796023.2

Gene Ontology
Bibliography

Related articles in PubMed

Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.
Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y
Proceedings of the National Academy of Sciences of the United States of America113(10)2762-7(2016 Mar)

High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies.
Quill? ML, Carat S, Qu?m?ner-Redon S, Hirchaud E, Baron D, Benech C, Guihot J, Placet M, Mignen O, F?rec C, Houlgatte R, Friocourt G
PloS one6(9)e25181(2011)

Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.
Ikeda A, Miyazaki T, Kakizawa S, Okuno Y, Tsuchiya S, Myomoto A, Saito SY, Yamamoto T, Yamazaki T, Iino M, Tsujimoto G, Watanabe M, Takeshima H
Biochemical and biophysical research communications363(3)835-9(2007 Nov)

Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.
Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo H, Kano M, Watanabe M, Iino M, Takeshima H
The EMBO journal26(7)1924-33(2007 Apr)

Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.
Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito SY, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H
Proceedings of the National Academy of Sciences of the United States of America103(28)10811-6(2006 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that junctophilin-4 (JP4) is expressed in T cells and localized at the endoplasmic reticulum-plasma membrane junctions to regulate Ca(2+) signaling.
Title: Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.

Gene expression was slightly altered in the JP-3 and JP-4 Knockout cerebellum.
Title: Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.

Jph4 seems to have an essential role in neural excitability fundamental to plasticity and integrated functions.
Title: Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.

The following Jph4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jph4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05878	NM_177049.5 Latest version!	Mus musculus junctophilin 4 (Jph4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Jph4 ( NM_177049.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_796023.2 Mus musculus junctophilin 4 (Jph4), mRNA.

Price & Availability↑

CloneID	OMu05878
Clone ID Related Accession (Same CDS sequence)	NM_177049.5
Accession Version	NM_177049.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1887bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	junctophilin-4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC157212.2 and AB099712.1. On Mar 25, 2011 this sequence version replaced NM_177049.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY341261.1, BC052376.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCCCG GGGGCAAGTT CGACTTTGAC GACGGGGGCT GCTACGTGGG GGGCTGGGAG 
GCGGGGCGGG CACATGGCTA CGGCGTGTGC ACCGGGCCCG GCGCCCAGGG AGAGTACAGC 
GGCTGCTGGG CTCACGGCTT CGAGTCGCTG GGTGTCTTCA CGGGGCCCGG CGGACACAGT 
TACCAGGGCC ACTGGCAGCA GGGCAAGCGC GAAGGGCTGG GCGTGGAGCG CAAGAGCCGC 
TGGACCTACC GCGGCGAGTG GCTGGGCGGG CTGAAGGGGC GCAGCGGCGT ATGGGAGAGC 
GTGTCCGGCC TGCGCTACGC CGGGCTCTGG AAGGACGGCT TCCAGGACGG CTACGGCACC 
GAGACCTACT CGGATGGAGG CACTTACCAA GGCCAGTGGC AAGCCGGGAA ACGCCACGGC 
TACGGGGTGC GCCAAAGTGT ACCCTACCAC CAGGCGGCGC TTCTGCGCTC ACCCCGCCGC 
ACCTCCCTGG ACTCCGGCCA CAGCGACCCC CCGACGCCGC CTCCACCCCT ACCCCTACCA 
GGAGATGAAG GAGGCAGCCC AGCCTCCGGC TCCCGAGGCG GCTTCGTGCT GGCGGGGCCA 
GGGGACGCCG ACGGGGCGTC TTCCCGTAAG CGCACCCCAG CAGCAGGTGG ATTCTTCCGC 
CGTTCACTGC TGCTCAGCGG GCTCCGGGCT GGTGGGCGCC GCAGCTCCCT GGGCAGCAAG 
AGGGGATCTC TACGCAGCGA GGTGAGCAGC GAAGTGGGCA GTACAGGACC CCCGGGCTCC 
GAGGCCAGCG GGCCCCCAAT CCCAGCTCCA CCTGCCCTCA TCGAGGGCTC AGCCACTGAG 
GTGTACGCCG GTGAGTGGCG TGCGGACCGG CGCAGTGGCT ATGGAGTGAG CCAGAGATCC 
AACGGGCTGC GCTACGAAGG CGAGTGGCTG GGCAACCGAC GCCACGGATA CGGGCGCACC 
ACCCGGCCCG ATGGCTCCCG TGAGGAGGGC AAGTACAAGC GTAACCGGCT GGTACACGGG 
GGACGTGTCC GCAGCCTCCT GCCTCTGGCC CTTAGACGGG GCAAAGTCAA GGAGAAAGTG 
GACAGGGCTG TCGAAGGTGC CCGTCGAGCT GTGAGTGCTG CCCGCCAGCG CCAGGAAATT 
GCGGCTGCCA GGGCAGCAGA CGCCCTCCTA AAAGCAGTGG CAGCCAGCAG CGTCGCGGAG 
AAGGCTGTGG AGGCTGCGCG GATGGCCAAG CTGATAGCCC AGGATCTACA ACCCATGTTA 
GAGGCCCCAG GCCGCAGACC CAGACAGGAC TCAGGAGGTT CTGACACAGA GCCTTTGGAT 
GAGGACAGCC CTGGGGTATA CGAGAATGGA CTGACCCCCT CAGAGGGCTC TCCGGAACTA 
CCCAGCAGCC CCGCCTCCTC CCACCAACCT TGGCGAGCCC CTGCCTGCCG GAGTCCACTG 
CCTCCTGGAG GGAACTGGGG CCCCTTCTCC AGCCCTAAAG CTTGGCCCGA GGAGTGGGGG 
GGTCCTGGTG AGCAGGCAGA GGAACTAGCT GGCTATGAGG CTGAGGATGA GGCTGGGGTG 
CAGGGTCCAG GACCAAGAGA TGGTTCCCCA CTTCTCGGAG GCTGCAGTGA CAGTTCAGGA 
AGTCTTCGAG AGGAGGAGGG GGAAGACGAA GAGTCCTTGC CCCAACTGAG GGCCCCAGGA 
GGCTCAGAGT CTGAGCCTGT CACCACGCCA GTTTTGAGGG GCCTGTCTTC AAGGGGTCCT 
GATGCTGGGT GCCTGACAGA AGAGGTTGAG GAGCCTGCTC CCACCGAGAG GCCTGCCCAG 
CCGGGAGCTG CCAACCCCCT GGTGGTGGGA GCCGTGGCCT TGCTGGACCT CAGCCTGGCC 
TTCCTGTTCT CCCAGCTCCT CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_796023.2
CDS	1117..3003
Translation	MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSHQPWRAPACRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEELAGYEAEDEAGVQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEPVTTPVLRGLSSRGPDAGCLTEEVEEPAPTERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT

Target ORF information:

RefSeq Version	NM_177049.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus junctophilin 4 (Jph4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177049.5

ORF Insert Sequence:

ATGTCCCCCG GGGGCAAGTT CGACTTTGAC GACGGGGGCT GCTACGTGGG GGGCTGGGAG 
GCGGGGCGGG CACATGGCTA CGGCGTGTGC ACCGGGCCCG GCGCCCAGGG AGAGTACAGC 
GGCTGCTGGG CTCACGGCTT CGAGTCGCTG GGTGTCTTCA CGGGGCCCGG CGGACACAGT 
TACCAGGGCC ACTGGCAGCA GGGCAAGCGC GAAGGGCTGG GCGTGGAGCG CAAGAGCCGC 
TGGACCTACC GCGGCGAGTG GCTGGGCGGG CTGAAGGGGC GCAGCGGCGT ATGGGAGAGC 
GTGTCCGGCC TGCGCTACGC CGGGCTCTGG AAGGACGGCT TCCAGGACGG CTACGGCACC 
GAGACCTACT CGGATGGAGG CACTTACCAA GGCCAGTGGC AAGCCGGGAA ACGCCACGGC 
TACGGGGTGC GCCAAAGTGT ACCCTACCAC CAGGCGGCGC TTCTGCGCTC ACCCCGCCGC 
ACCTCCCTGG ACTCCGGCCA CAGCGACCCC CCGACGCCGC CTCCACCCCT ACCCCTACCA 
GGAGATGAAG GAGGCAGCCC AGCCTCCGGC TCCCGAGGCG GCTTCGTGCT GGCGGGGCCA 
GGGGACGCCG ACGGGGCGTC TTCCCGTAAG CGCACCCCAG CAGCAGGTGG ATTCTTCCGC 
CGTTCACTGC TGCTCAGCGG GCTCCGGGCT GGTGGGCGCC GCAGCTCCCT GGGCAGCAAG 
AGGGGATCTC TACGCAGCGA GGTGAGCAGC GAAGTGGGCA GTACAGGACC CCCGGGCTCC 
GAGGCCAGCG GGCCCCCAAT CCCAGCTCCA CCTGCCCTCA TCGAGGGCTC AGCCACTGAG 
GTGTACGCCG GTGAGTGGCG TGCGGACCGG CGCAGTGGCT ATGGAGTGAG CCAGAGATCC 
AACGGGCTGC GCTACGAAGG CGAGTGGCTG GGCAACCGAC GCCACGGATA CGGGCGCACC 
ACCCGGCCCG ATGGCTCCCG TGAGGAGGGC AAGTACAAGC GTAACCGGCT GGTACACGGG 
GGACGTGTCC GCAGCCTCCT GCCTCTGGCC CTTAGACGGG GCAAAGTCAA GGAGAAAGTG 
GACAGGGCTG TCGAAGGTGC CCGTCGAGCT GTGAGTGCTG CCCGCCAGCG CCAGGAAATT 
GCGGCTGCCA GGGCAGCAGA CGCCCTCCTA AAAGCAGTGG CAGCCAGCAG CGTCGCGGAG 
AAGGCTGTGG AGGCTGCGCG GATGGCCAAG CTGATAGCCC AGGATCTACA ACCCATGTTA 
GAGGCCCCAG GCCGCAGACC CAGACAGGAC TCAGGAGGTT CTGACACAGA GCCTTTGGAT 
GAGGACAGCC CTGGGGTATA CGAGAATGGA CTGACCCCCT CAGAGGGCTC TCCGGAACTA 
CCCAGCAGCC CCGCCTCCTC CCACCAACCT TGGCGAGCCC CTGCCTGCCG GAGTCCACTG 
CCTCCTGGAG GGAACTGGGG CCCCTTCTCC AGCCCTAAAG CTTGGCCCGA GGAGTGGGGG 
GGTCCTGGTG AGCAGGCAGA GGAACTAGCT GGCTATGAGG CTGAGGATGA GGCTGGGGTG 
CAGGGTCCAG GACCAAGAGA TGGTTCCCCA CTTCTCGGAG GCTGCAGTGA CAGTTCAGGA 
AGTCTTCGAG AGGAGGAGGG GGAAGACGAA GAGTCCTTGC CCCAACTGAG GGCCCCAGGA 
GGCTCAGAGT CTGAGCCTGT CACCACGCCA GTTTTGAGGG GCCTGTCTTC AAGGGGTCCT 
GATGCTGGGT GCCTGACAGA AGAGGTTGAG GAGCCTGCTC CCACCGAGAG GCCTGCCCAG 
CCGGGAGCTG CCAACCCCCT GGTGGTGGGA GCCGTGGCCT TGCTGGACCT CAGCCTGGCC 
TTCCTGTTCT CCCAGCTCCT CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.
Proceedings of the National Academy of Sciences of the United States of America113(10)2762-7(2016 Mar)
Woo JS,Srikanth S,Nishi M,Ping P,Takeshima H,Gwack Y

High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies.
PloS one6(9)e25181(2011)
Quill? ML,Carat S,Qu?m?ner-Redon S,Hirchaud E,Baron D,Benech C,Guihot J,Placet M,Mignen O,F?rec C,Houlgatte R,Friocourt G

Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.
Biochemical and biophysical research communications363(3)835-9(2007 Nov)
Ikeda A,Miyazaki T,Kakizawa S,Okuno Y,Tsuchiya S,Myomoto A,Saito SY,Yamamoto T,Yamazaki T,Iino M,Tsujimoto G,Watanabe M,Takeshima H

Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.
The EMBO journal26(7)1924-33(2007 Apr)
Kakizawa S,Kishimoto Y,Hashimoto K,Miyazaki T,Furutani K,Shimizu H,Fukaya M,Nishi M,Sakagami H,Ikeda A,Kondo H,Kano M,Watanabe M,Iino M,Takeshima H

Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.
Proceedings of the National Academy of Sciences of the United States of America103(28)10811-6(2006 Jul)
Moriguchi S,Nishi M,Komazaki S,Sakagami H,Miyazaki T,Masumiya H,Saito SY,Watanabe M,Kondo H,Yawo H,Fukunaga K,Takeshima H

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Jph4 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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