Gene Symbol | Lhfpl5 |
Entrez Gene ID | 328789 |
Full Name | lipoma HMGIC fusion partner-like 5 |
Synonyms | 9330179O15Rik,Tmhs,hscy |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Lhfpl5 cDNA ORF clone
Gene Symbol | Lhfpl5 |
Entrez Gene ID | 328789 |
Full Name | lipoma HMGIC fusion partner-like 5 |
Synonyms | 9330179O15Rik,Tmhs,hscy |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006524433.3 | XP_006524496.1 | tetraspan membrane protein of hair cell stereocilia isoform X1 |
NM_026571.2 | NP_080847.2 | LHFPL tetraspan subfamily member 5 protein |
XM_006524433.4 | XP_006524496.1 | LHFPL tetraspan subfamily member 5 protein isoform X1 |
LOC718952 | XP_001112357.2 | |
Canis lupus familiaris (dog) | LHFPL5 | XP_005627321.1 |
Rattus norvegicus (Norway rat) | Lhfpl5 | NP_001013928.1 |
Gallus gallus (chicken) | LHFPL5 | NP_989729.1 |
Danio rerio (zebrafish) | lhfpl5a | XP_686620.5 |
Homo sapiens (human) | LHFPL5 | NP_872354.1 |
Caenorhabditis elegans (roundworm) | F26D10.11 | NP_503066.1 |
Bos taurus (cattle) | LHFPL5 | NP_001192875.1 |
Mus musculus (house mouse) | Lhfpl5 | NP_080847.2 |
Xenopus tropicalis (tropical clawed frog) | lhfpl5 | NP_001017269.1 |
Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15.
Mahendrasingam S, Fettiplace R, Alagramam KN, Cross E, Furness DN
PloS one12(10)e0185285(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
data show that LHFPL5 is already present in the MET apparatus at P0 but requires PCDH15 at P3 to remain there. Shaft/ankle link localisation suggests it interacts with link proteins other than PCDH15
Title: Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15.
TMHS is an integral component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel.
Title: TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells.
Hurry-scurry (hscy)-2J, a mutation of Tmhs, causes abnormal splicing from a cryptic splice site within exon 2 that is predicted to produce a functionally null protein lacking 51 amino acids of the wild-type sequence.
Title: Targeted knockout and lacZ reporter expression of the mouse Tmhs deafness gene and characterization of the hscy-2J mutation.
TMHS localizes to the apical membrane of inner ear hair cells during stereocilia formation suggesting a function in hair bundle morphogenesis; a missense mutation underlies deafness in hurry-scurry mice.
Title: A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.
The following Lhfpl5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lhfpl5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu53705 | |
Clone ID Related Accession (Same CDS sequence) | XM_006524433.3 , XM_006524433.4 | |
Accession Version | XM_006524433.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | tetraspan membrane protein of hair cell stereocilia isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006524433.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGAAGT TGCTGCCAGC CCAGGAGGCC GCCAAGATCT ACCACACCAA CTATGTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006524496.1 |
CDS | 633..1382 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006524433.3 |
1 | ATGGTGAAGT TGCTGCCAGC CCAGGAGGCC GCCAAGATCT ACCACACCAA CTATGTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02601 | |
Clone ID Related Accession (Same CDS sequence) | NM_026571.2 | |
Accession Version | NM_026571.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | LHFPL tetraspan subfamily member 5 protein | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY721459.1 and BC099483.1. On Nov 15, 2007 this sequence version replaced NM_026571.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099483.1, AK020389.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTGAAGT TGCTGCCAGC CCAGGAGGCC GCCAAGATCT ACCACACCAA CTATGTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080847.2 |
CDS | 283..942 |
Translation |
Target ORF information:
Target ORF information:
|
NM_026571.2 |
1 | ATGGTGAAGT TGCTGCCAGC CCAGGAGGCC GCCAAGATCT ACCACACCAA CTATGTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu53705 | |
Clone ID Related Accession (Same CDS sequence) | XM_006524433.3 , XM_006524433.4 | |
Accession Version | XM_006524433.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | LHFPL tetraspan subfamily member 5 protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006524433.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGAAGT TGCTGCCAGC CCAGGAGGCC GCCAAGATCT ACCACACCAA CTATGTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006524496.1 |
CDS | 633..1382 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006524433.4 |
1 | ATGGTGAAGT TGCTGCCAGC CCAGGAGGCC GCCAAGATCT ACCACACCAA CTATGTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15. |