Gene Symbol | Sdk1 |
Entrez Gene ID | 330222 |
Full Name | sidekick cell adhesion molecule 1 |
Synonyms | 5330440E10,6720466O15Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Sdk1 cDNA ORF clone
Gene Symbol | Sdk1 |
Entrez Gene ID | 330222 |
Full Name | sidekick cell adhesion molecule 1 |
Synonyms | 5330440E10,6720466O15Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_177879.5 | NP_808547.3 | protein sidekick-1 |
XM_006504712.1 | XP_006504775.1 | protein sidekick-1 isoform X1 |
Pan troglodytes (chimpanzee) | SDK1 | XP_518946.3 |
Mus musculus (house mouse) | Sdk1 | NP_808547.3 |
Rattus norvegicus (Norway rat) | Sdk1 | XP_006248970.1 |
Gallus gallus (chicken) | SDK1 | NP_989436.1 |
SDK1 | XP_001105243.2 | |
Bos taurus (cattle) | SDK1 | XP_002698210.2 |
Danio rerio (zebrafish) | sdk1a | XP_686686.3 |
Homo sapiens (human) | SDK1 | NP_689957.3 |
Canis lupus familiaris (dog) | SDK1 | XP_005621203.1 |
Molecular basis of sidekick-mediated cell-cell adhesion and specificity.
Goodman KM, Yamagata M, Jin X, Mannepalli S, Katsamba PS, Ahls?n G, Sergeeva AP, Honig B, Sanes JR, Shapiro L
eLife5(2016 09)
Sidekick 2 directs formation of a retinal circuit that detects differential motion.
Krishnaswamy A, Yamagata M, Duan X, Hong YK, Sanes JR
Nature524(7566)466-470(2015 Aug)
Essential role of poly(ADP-ribosyl)ation in cocaine action.
Scobie KN, Damez-Werno D, Sun H, Shao N, Gancarz A, Panganiban CH, Dias C, Koo J, Caiafa P, Kaufman L, Neve RL, Dietz DM, Shen L, Nestler EJ
Proceedings of the National Academy of Sciences of the United States of America111(5)2005-10(2014 Feb)
Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.
Nedelko T, Kollmus H, Klawonn F, Spijker S, Lu L, He?man M, Alberts R, Williams RW, Schughart K
BMC genomics13411(2012 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Here the authors report crystal structures of Sdk1 and Sdk2 ectodomain regions, revealing similar homodimers mediated by the four N-terminal immunoglobulin domains (Ig1-4), arranged in a horseshoe conformation.
Title: Molecular basis of sidekick-mediated cell-cell adhesion and specificity.
Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function.
Title: Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis.
-1 is an important mediator of cellular adhesion in HIV-infected podocytes and may contribute to podocyte clustering that is characteristic of pseudocrescent formation in HIV-associated nephropathy
Title: The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy.
results establish that the first and second immunoglobulin domains of sidekick-1 and -2 are necessary and sufficient to mediate and target homophilic adhesion
Title: Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.
sidekick is expressed in ureteric bud and ureteric bud-derived tissues and may play a role in branching morphogenesis
Title: Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy.
The following Sdk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sdk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu21264 | |
Clone ID Related Accession (Same CDS sequence) | NM_177879.5 | |
Accession Version | NM_177879.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 6582bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Mus musculus(house mouse) | |
Product | protein sidekick-1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147578.1 and AK086302.1. On Jan 9, 2008 this sequence version replaced NM_177879.4. ##Evidence-Data-START## Transcript exon combination :: AK147578.1, BC060237.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCCGCG CCCGGCCCTC GGTGGCGGGC GGCGGAGTCG CGGCGCCCCC TGAGCGAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_808547.3 |
CDS | 316..6897 |
Translation |
Target ORF information:
Target ORF information:
|
NM_177879.5 |
1 | ATGGCCCGCG CCCGGCCCTC GGTGGCGGGC GGCGGAGTCG CGGCGCCCCC TGAGCGAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu36318 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504712.1 | |
Accession Version | XM_006504712.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 6387bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | protein sidekick-1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCCGCG CCCGGCCCTC GGTGGCGGGC GGCGGAGTCG CGGCGCCCCC TGAGCGAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504775.1 |
CDS | 353..6739 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006504712.1 |
1 | ATGGCCCGCG CCCGGCCCTC GGTGGCGGGC GGCGGAGTCG CGGCGCCCCC TGAGCGAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Molecular basis of sidekick-mediated cell-cell adhesion and specificity. |
Sidekick 2 directs formation of a retinal circuit that detects differential motion. |
Essential role of poly(ADP-ribosyl)ation in cocaine action. |
Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. |