Gene Symbol | Hs6st1 |
Entrez Gene ID | 50785 |
Full Name | heparan sulfate 6-O-sulfotransferase 1 |
Synonyms | 6Ost1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Hs6st1 cDNA ORF clone
Gene Symbol | Hs6st1 |
Entrez Gene ID | 50785 |
Full Name | heparan sulfate 6-O-sulfotransferase 1 |
Synonyms | 6Ost1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_015818.2 | NP_056633.2 | heparan-sulfate 6-O-sulfotransferase 1 |
Homo sapiens (human) | HS6ST1 | NP_004798.3 |
LOC715479 | XP_001105734.2 | |
Xenopus tropicalis (tropical clawed frog) | hs6st1 | NP_001017317.1 |
Gallus gallus (chicken) | HS6ST1 | NP_989813.1 |
Danio rerio (zebrafish) | hs6st1b | NP_001073672.1 |
Drosophila melanogaster (fruit fly) | Hs6st | NP_001262750.1 |
Bos taurus (cattle) | HS6ST1 | NP_001179420.1 |
Mus musculus (house mouse) | Hs6st1 | NP_056633.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001444 | XP_321686.5 |
Rattus norvegicus (Norway rat) | Hs6st1 | NP_001101680.1 |
Danio rerio (zebrafish) | hs6st1a | NP_001018344.2 |
Pan troglodytes (chimpanzee) | HS6ST1 | XP_001141733.1 |
FGF8 morphogen gradients are differentially regulated by heparan sulphotransferases Hs2st and Hs6st1 in the developing brain.
Chan WK, Price DJ, Pratt T
Biology open6(12)1933-1942(2017 Dec)
2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration.
Tillo M, Charoy C, Schwarz Q, Maden CH, Davidson K, Fantin A, Ruhrberg C
Development (Cambridge, England)143(11)1907-13(2016 06)
Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis.
Cai Z, Grobe K, Zhang X
Developmental dynamics : an official publication of the American Association of Anatomists243(10)1310-6(2014 Oct)
FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.
Chen Z, Huang J, Liu Y, Dattilo LK, Huh SH, Ornitz D, Beebe DC
Development (Cambridge, England)141(13)2691-701(2014 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
both HS6ST-1 and HS6ST-2 are involved in 6-O-sulfation of heparin and that the proper packaging and storage of tryptase
Title: Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin.
Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.
Title: Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.
there is a critical role for HS 6-O sulfation by Hs6st1 in postnatal processes
Title: Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis.
Hs2st and/or Hs6st1 expression coincides with Slit expression domains at locations where retinal ganglion cell(RGC) axons make navigation errors in Hs2st-/- and Hs6st1-/- mutants, and Hs6st1-/-RGC axons are less sensitive to Slit2 repulsion.
Title: Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm.
Data show that high expression of 6-O-sulfotransferase (6-OST)-1, 2, or 3 resulted in increased 6-O-sulfation of N-sulfated and N-acetylated glucosamine units, and in altered heparan sulfate domain structure.
Title: Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation.
The following Hs6st1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hs6st1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19195 | |
Clone ID Related Accession (Same CDS sequence) | NM_015818.2 | |
Accession Version | NM_015818.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | heparan-sulfate 6-O-sulfotransferase 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052316.1 and AI182294.1. On Mar 26, 2009 this sequence version replaced NM_015818.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052316.1, AK157556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCGGCGGC GGCGCGCCGG CGGCAGGACC ATGGTTGAGC GCGCCAGCAA GTTCGTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_056633.2 |
CDS | 259..1494 |
Translation |
Target ORF information:
Target ORF information:
|
NM_015818.2 |
1 | ATGCGGCGGC GGCGCGCCGG CGGCAGGACC ATGGTTGAGC GCGCCAGCAA GTTCGTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
FGF8 morphogen gradients are differentially regulated by heparan sulphotransferases Hs2st and Hs6st1 in the developing brain. |
2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration. |
Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis. |
FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. |