Gene Symbol | Cntnap1 |
Entrez Gene ID | 53321 |
Full Name | contactin associated protein-like 1 |
Synonyms | AI841080,Caspr,NCP1,Nrxn4,p190,shm |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cntnap1 cDNA ORF clone
Gene Symbol | Cntnap1 |
Entrez Gene ID | 53321 |
Full Name | contactin associated protein-like 1 |
Synonyms | AI841080,Caspr,NCP1,Nrxn4,p190,shm |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006533728.3 | XP_006533791.1 | contactin-associated protein 1 isoform X1 |
XM_006533729.4 | XP_006533792.1 | contactin-associated protein 1 isoform X2 |
XM_006533729.3 | XP_006533792.1 | contactin-associated protein 1 isoform X1 |
XM_030246150.1 | XP_030102010.1 | contactin-associated protein 1 isoform X1 |
NM_016782.2 | NP_058062.2 | contactin-associated protein 1 precursor |
XM_006533730.3 | XP_006533793.1 | contactin-associated protein 1 isoform X2 |
CNTNAP1 | XP_001111174.1 | |
Canis lupus familiaris (dog) | CNTNAP1 | XP_548083.3 |
Mus musculus (house mouse) | Cntnap1 | NP_058062.2 |
Danio rerio (zebrafish) | LOC566220 | XP_694580.5 |
Bos taurus (cattle) | CNTNAP1 | NP_001193824.1 |
Rattus norvegicus (Norway rat) | Cntnap1 | NP_114450.1 |
Xenopus tropicalis (tropical clawed frog) | cntnap1 | NP_001090759.1 |
Homo sapiens (human) | CNTNAP1 | NP_003623.1 |
Pan troglodytes (chimpanzee) | CNTNAP1 | XP_511518.2 |
Gallus gallus (chicken) | CNTNAP1 | XP_003642874.2 |
Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system.
Lee JY, Kim MJ, Li L, Velumian AA, Aui PM, Fehlings MG, Petratos S
Scientific reports7(1)8958(2017 Aug)
Axonal domain disorganization in Caspr1 and Caspr2 mutant myelinated axons affects neuromuscular junction integrity, leading to muscle atrophy.
Saifetiarova J, Liu X, Taylor AM, Li J, Bhat MA
Journal of neuroscience research95(7)1373-1390(2017 Jul)
Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.
Hu B, Arpag S, Zhang X, M?bius W, Werner H, Sosinsky G, Ellisman M, Zhang Y, Hamilton A, Chernoff J, Li J
PLoS genetics12(9)e1006290(2016 Sep)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Simultaneous deletion of Caspr and Caspr2 disrupts the internodal organization of Kv1.2.
Title: Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons.
Caspr co-localizes and interacts with APP. Amyloid-beta (Abeta) 40 and Abeta42 generation were also reduced in HEK-APP cells by Caspr overexpression.
Title: Caspr interaction with Amyloid Precursor Protein reduces amyloid-? generation in vitro.
Caspr labeling was observed through much of the retina, including horizontal, bipolar, amacrine, and ganglion cells.
Title: Localization of the paranodal protein Caspr in the mammalian retina.
Clustering of Caspr at initial contact sites between OL processes and the axon requires glial expression of NF155 but not of contactin. Expression of membrane proteins along the axolemma is determined by the type of the contacting glial cells.
Title: Differential clustering of Caspr by oligodendrocytes and Schwann cells.
The Caspr gene has been identified in the neurological mutant shambling (shm) mouse and shown to encode the contactin-associated protein, which is a major component of the paranodal junction in myelinated nerves.
Title: A novel Caspr mutation causes the shambling mouse phenotype by disrupting axoglial interactions of myelinated nerves.
The following Cntnap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cntnap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22038 | |
Clone ID Related Accession (Same CDS sequence) | XM_030246150.1 , NM_016782.2 | |
Accession Version | NM_016782.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4158bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-03 | |
Organism | Mus musculus(house mouse) | |
Product | contactin-associated protein 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL590969.12, AF039833.1 and CN538743.1. On Oct 12, 2006 this sequence version replaced NM_016782.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF039833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGATGAGTC TCCGGCTCTT CAGCATCCTG CTCGCCACGG TGGTCTCTGG AGCTTGGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_058062.2 |
CDS | 142..4299 |
Translation |
Target ORF information:
Target ORF information:
|
NM_016782.2 |
1 | ATGATGAGTC TCCGGCTCTT CAGCATCCTG CTCGCCACGG TGGTCTCTGG AGCTTGGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46602 | |
Clone ID Related Accession (Same CDS sequence) | XM_006533728.3 , XM_006533729.4 , XM_006533729.3 | |
Accession Version | XM_006533728.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3927bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | contactin-associated protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006533728.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGC ATCGGATCCG GGCTGTGGCC ACACAGGGAG CTTTTAATTC TTGGGATTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006533791.1 |
CDS | 223..4149 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006533728.3 |
1 | ATGAAGAAGC ATCGGATCCG GGCTGTGGCC ACACAGGGAG CTTTTAATTC TTGGGATTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46602 | |
Clone ID Related Accession (Same CDS sequence) | XM_006533728.3 , XM_006533729.4 , XM_006533729.3 | |
Accession Version | XM_006533729.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3927bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | contactin-associated protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006533729.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGC ATCGGATCCG GGCTGTGGCC ACACAGGGAG CTTTTAATTC TTGGGATTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006533792.1 |
CDS | 420..4346 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006533729.3 |
1 | ATGAAGAAGC ATCGGATCCG GGCTGTGGCC ACACAGGGAG CTTTTAATTC TTGGGATTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22038 | |
Clone ID Related Accession (Same CDS sequence) | XM_030246150.1 , NM_016782.2 | |
Accession Version | XM_030246150.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4158bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | contactin-associated protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGAGTC TCCGGCTCTT CAGCATCCTG CTCGCCACGG TGGTCTCTGG AGCTTGGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030102010.1 |
CDS | 1527..5684 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030246150.1 |
1 | ATGATGAGTC TCCGGCTCTT CAGCATCCTG CTCGCCACGG TGGTCTCTGG AGCTTGGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46602 | |
Clone ID Related Accession (Same CDS sequence) | XM_006533728.3 , XM_006533729.4 , XM_006533729.3 | |
Accession Version | XM_006533729.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3927bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | contactin-associated protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006533729.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGC ATCGGATCCG GGCTGTGGCC ACACAGGGAG CTTTTAATTC TTGGGATTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006533792.1 |
CDS | 420..4346 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006533729.4 |
1 | ATGAAGAAGC ATCGGATCCG GGCTGTGGCC ACACAGGGAG CTTTTAATTC TTGGGATTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46603 | |
Clone ID Related Accession (Same CDS sequence) | XM_006533730.3 | |
Accession Version | XM_006533730.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3459bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | contactin-associated protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006533730.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGAGTC TCCGGCTCTT CAGCATCCTG CTCGCCACGG TGGTCTCTGG AGCTTGGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006533793.1 |
CDS | 197..3655 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006533730.3 |
1 | ATGATGAGTC TCCGGCTCTT CAGCATCCTG CTCGCCACGG TGGTCTCTGG AGCTTGGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system. |
Axonal domain disorganization in Caspr1 and Caspr2 mutant myelinated axons affects neuromuscular junction integrity, leading to muscle atrophy. |
Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. |
High-throughput discovery of novel developmental phenotypes. |