Gene Symbol | Map3k6 |
Entrez Gene ID | 53608 |
Full Name | mitogen-activated protein kinase kinase kinase 6 |
Synonyms | Ask2,MAPKKK6,MEKK6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Map3k6 cDNA ORF clone
gRNAs
Gene Symbol | Map3k6 |
Entrez Gene ID | 53608 |
Full Name | mitogen-activated protein kinase kinase kinase 6 |
Synonyms | Ask2,MAPKKK6,MEKK6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_016693.5 | NP_057902.5 | mitogen-activated protein kinase kinase kinase 6 |
XM_006539040.4 | XP_006539103.1 | mitogen-activated protein kinase kinase kinase 6 isoform X1 |
XM_006539040.3 | XP_006539103.1 | mitogen-activated protein kinase kinase kinase 6 isoform X1 |
XM_006539041.3 | XP_006539104.1 | mitogen-activated protein kinase kinase kinase 6 isoform X2 |
XM_006539041.4 | XP_006539104.1 | mitogen-activated protein kinase kinase kinase 6 isoform X2 |
Canis lupus familiaris (dog) | MAP3K6 | XP_005617983.1 |
Mus musculus (house mouse) | Map3k6 | NP_057902.5 |
Homo sapiens (human) | MAP3K6 | NP_004663.3 |
Gallus gallus (chicken) | MAP3K6 | XP_003642613.2 |
Rattus norvegicus (Norway rat) | Map3k6 | NP_001101379.1 |
Pan troglodytes (chimpanzee) | MAP3K6 | XP_513244.2 |
MAP3K6 | XP_001111161.1 | |
Bos taurus (cattle) | MAP3K6 | NP_001180165.1 |
ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.
Place DE, Samir P, Karki R, Briard B, Vogel P, Kanneganti TD
The American journal of pathology(2018 Jan)
Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential.
G?rnikiewicz B, Ronowicz A, Krzemi?ski M, Sachadyn P
BMC genomics17231(2016 Mar)
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y
Science signaling8(388)ra78(2015 Aug)
In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D, Gondin J
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that deletion of either MAPKKK5 ASK1 or MAPKKK6 ASK2 in mice promoted the replication of influenza A virus in the lung.
Title: The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
Title: Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
The following Map3k6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu34337 | |
Clone ID Related Accession (Same CDS sequence) | XM_006539041.3 , XM_006539041.4 | |
Accession Version | XM_006539041.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1944bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | mitogen-activated protein kinase kinase kinase 6 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006539041.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006539104.1 |
CDS | 1433..3376 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu34337 | |
Clone ID Related Accession (Same CDS sequence) | XM_006539041.3 , XM_006539041.4 | |
Accession Version | XM_006539041.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1944bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | mitogen-activated protein kinase kinase kinase 6 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006539041.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006539104.1 |
CDS | 3111..5054 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu34336 | |
Clone ID Related Accession (Same CDS sequence) | XM_006539040.4 , XM_006539040.3 | |
Accession Version | XM_006539040.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3852bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | mitogen-activated protein kinase kinase kinase 6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006539040.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006539103.1 |
CDS | 3111..6962 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu10455 | |
Clone ID Related Accession (Same CDS sequence) | NM_016693.5 | |
Accession Version | NM_016693.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3876bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-14 | |
Organism | Mus musculus(house mouse) | |
Product | mitogen-activated protein kinase kinase kinase 6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL837525.5 and AL671882.6. On Mar 21, 2009 this sequence version replaced NM_016693.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB021861.4, BC120565.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057902.5 |
CDS | 272..4147 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu34336 | |
Clone ID Related Accession (Same CDS sequence) | XM_006539040.4 , XM_006539040.3 | |
Accession Version | XM_006539040.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3852bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | mitogen-activated protein kinase kinase kinase 6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006539040.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006539103.1 |
CDS | 1427..5278 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGGGC CATGTCCTGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. |
Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential. |
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. |
In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. |