Gene Symbol | Acrbp |
Entrez Gene ID | 54137 |
Full Name | proacrosin binding protein |
Synonyms | OY-TES-1,sp32 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Acrbp cDNA ORF clone
gRNAs
Gene Symbol | Acrbp |
Entrez Gene ID | 54137 |
Full Name | proacrosin binding protein |
Synonyms | OY-TES-1,sp32 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_016845.2 | NP_058541.2 | acrosin-binding protein isoform 1 precursor |
NM_001127340.1 | NP_001120812.1 | acrosin-binding protein isoform 2 precursor |
Rattus norvegicus (Norway rat) | Acrbp | NP_001020220.1 |
Pan troglodytes (chimpanzee) | ACRBP | NP_001233534.1 |
Bos taurus (cattle) | ACRBP | XP_002687915.1 |
Homo sapiens (human) | ACRBP | NP_115878.2 |
ACRBP | XP_001107683.1 | |
Mus musculus (house mouse) | Acrbp | NP_058541.2 |
Gallus gallus (chicken) | ACRBP | XP_004938169.1 |
Canis lupus familiaris (dog) | ACRBP | XP_534908.2 |
Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse.
Kanemori Y, Koga Y, Sudo M, Kang W, Kashiwabara S, Ikawa M, Hasuwa H, Nagashima K, Ishikawa Y, Ogonuki N, Ogura A, Baba T
Proceedings of the National Academy of Sciences of the United States of America113(26)E3696-705(2016 06)
Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse.
Kanemori Y, Ryu JH, Sudo M, Niida-Araida Y, Kodaira K, Takenaka M, Kohno N, Sugiura S, Kashiwabara S, Baba T
Biology of reproduction88(4)105(2013 Apr)
Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.
Tardif S, Guyonnet B, Cormier N, Cornwall GA
Molecular human reproduction18(6)298-307(2012 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
ACRBP-null male mice showed a severely reduced fertility, because of malformation of the acrosome.
Title: Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse.
Two forms of Acrbp mRNA-wild-type Acrbp-W and variant Acrbp-V5 mRNAs-were generated by alternative splicing of Acrbp in the mouse.
Title: Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse.
Data suggest that the fertility defect in PCSK4 (proprotein convertase subtilisin/kexin type 4) knockout mice is due, in part, to altered processing/proteolysis of ACRBP as well as structural abnormalities in sperm heads and acrosomes.
Title: Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.
The following Acrbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acrbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu10778 | |
Clone ID Related Accession (Same CDS sequence) | NM_016845.2 | |
Accession Version | NM_016845.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1623bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | acrosin-binding protein isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY099028.1 and AK132705.1. On May 14, 2008 this sequence version replaced NM_016845.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK132705.1, D17573.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGATGAATC TAGCTGCTGG CTTCCTTCTG ATGCTTCTGG AAGTGCTGCT CCTGCCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_058541.2 |
CDS | 84..1706 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGATGAATC TAGCTGCTGG CTTCCTTCTG ATGCTTCTGG AAGTGCTGCT CCTGCCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu05914 | |
Clone ID Related Accession (Same CDS sequence) | NM_001127340.1 | |
Accession Version | NM_001127340.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-21 | |
Organism | Mus musculus(house mouse) | |
Product | acrosin-binding protein isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY099028.1, BM938496.1 and AV260707.2. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in a protein (isoform 2) with a shorter, distinct C-terminus when compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK076691.1, BC011079.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGATGAATC TAGCTGCTGG CTTCCTTCTG ATGCTTCTGG AAGTGCTGCT CCTGCCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001120812.1 |
CDS | 84..1034 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGATGAATC TAGCTGCTGG CTTCCTTCTG ATGCTTCTGG AAGTGCTGCT CCTGCCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse. |
Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse. |
Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice. |