Gene Symbol | Crtam |
Entrez Gene ID | 54698 |
Full Name | cytotoxic and regulatory T cell molecule |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Crtam cDNA ORF clone
Gene Symbol | Crtam |
Entrez Gene ID | 54698 |
Full Name | cytotoxic and regulatory T cell molecule |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001281954.1 | NP_001268883.1 | cytotoxic and regulatory T-cell molecule isoform 1 precursor |
NM_019465.4 | NP_062338.3 | cytotoxic and regulatory T-cell molecule isoform 2 precursor |
Homo sapiens (human) | CRTAM | NP_062550.2 |
Canis lupus familiaris (dog) | CRTAM | XP_852857.2 |
Rattus norvegicus (Norway rat) | Crtam | NP_001100283.1 |
Bos taurus (cattle) | CRTAM | NP_001098927.1 |
Gallus gallus (chicken) | CRTAM | NP_001025518.1 |
CRTAM | XP_001107752.1 | |
Mus musculus (house mouse) | Crtam | NP_001268883.1 |
Pan troglodytes (chimpanzee) | CRTAM | XP_001136009.1 |
Danio rerio (zebrafish) | LOC101884219 | XP_005172764.1 |
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.
Takeuchi A, Badr Mel S, Miyauchi K, Ishihara C, Onishi R, Guo Z, Sasaki Y, Ike H, Takumi A, Tsuji NM, Murakami Y, Katakai T, Kubo M, Saito T
The Journal of experimental medicine213(1)123-38(2016 Jan)
CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.
Cortez VS, Cervantes-Barragan L, Song C, Gilfillan S, McDonald KG, Tussiwand R, Edelson BT, Murakami Y, Murphy KM, Newberry RD, Sibley LD, Colonna M
The Journal of experimental medicine211(4)623-33(2014 Apr)
Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-R?nne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD
Diabetologia55(1)154-65(2012 Jan)
Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM.
Cai Y, Xiong S, Zheng Y, Luo F, Jiang P, Chu Y
Cellular & molecular immunology8(4)359-67(2011 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene.
Title: CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.
During pathogenic infection, Crtam-Cadm1 interactions regulate the dynamic equilibrium between newly formed CD4(+) T cells and their retention in the gut.
Title: CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.
TCS upregulated the expression of tumor suppressor in lung cancer 1 (TSLC1) in 3LL tumor cells and the expression of its ligand, class I-restricted T cell-associated molecule (CRTAM), in effector T cells.
Title: Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM.
show that CRTAM has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development.
Title: Role of CRTAM during mouse early T lymphocytes development.
CRTAM expression is critical for the accumulation of antigen-specific cytotoxic T lymphocytes and their subsequent proliferation within the draining lymph node.
Title: CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node.
The following Crtam gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crtam cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu11015 | |
Clone ID Related Accession (Same CDS sequence) | NM_019465.4 | |
Accession Version | NM_019465.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-16 | |
Organism | Mus musculus(house mouse) | |
Product | cytotoxic and regulatory T-cell molecule isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159820.2, AK005719.1 and AK163744.1. On Aug 10, 2013 this sequence version replaced NM_019465.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF001104.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGTGGTGGG GAGCCCTCAG TTTGCTGTTC TGGGTGCCGG TGCAAGCAGC CTTTCTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_062338.3 |
CDS | 43..1221 |
Translation |
Target ORF information:
Target ORF information:
|
NM_019465.4 |
1 | ATGTGGTGGG GAGCCCTCAG TTTGCTGTTC TGGGTGCCGG TGCAAGCAGC CTTTCTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16795 | |
Clone ID Related Accession (Same CDS sequence) | NM_001281954.1 | |
Accession Version | NM_001281954.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-16 | |
Organism | Mus musculus(house mouse) | |
Product | cytotoxic and regulatory T-cell molecule isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159820.2, AK005719.1 and AK163744.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC117716.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGTGGTGGG GAGCCCTCAG TTTGCTGTTC TGGGTGCCGG TGCAAGCAGC CTTTCTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001268883.1 |
CDS | 43..1224 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001281954.1 |
1 | ATGTGGTGGG GAGCCCTCAG TTTGCTGTTC TGGGTGCCGG TGCAAGCAGC CTTTCTGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage. |
CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection. |
Pancreatic islet and progenitor cell surface markers with cell sorting potential. |
Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM. |